The effect of combined cognitive intervention and physical exercise on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials

Meng, Qiuyan; Yin, Hao; Wang, Shuo; Shang, Binghan; Meng, Xiangyi; Yan, Mingli; Li, Guichen; Chu, Jianfeng; Chen, Li

doi:10.1007/s40520-021-01877-0

Cited by 34 publications

(23 citation statements)

References 46 publications

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“… 5 , 62 Similar findings were reported in global cognition, memory, and executive function following multidomain interventions. 16 , 18 , 19 The present meta-analysis further contributes to the existing literature by demonstrating similar interactions that are not limited to cognitive and physical interventions. Findings from this study, however, must be interpreted with an understanding that effect sizes do not indicate clinical significance on tests such as the MMSE, which have limited sensitivity to detect meaningful changes in MCI.…”

Section: Discussionsupporting

confidence: 64%

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Associations of Multidomain Interventions With Improvements in Cognition in Mild Cognitive Impairment

et al. 2022

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Key Points Question Are multidomain interventions associated with better cognitive outcomes than single interventions in older adults with mild cognitive impairment (MCI)? Findings This meta-analysis of 28 studies with 2711 participants examined global cognition, attention, executive function, memory, processing speed, and verbal fluency effects. After intervention, significant improvements favoring multidomain interventions were observed in global cognition, executive function, memory, and verbal fluency compared with the single-intervention, active control. Meaning In this study, multidomain interventions were more strongly associated with improving global cognition, memory, executive function, and verbal fluency in older adults with MCI than single interventions, but evidence is needed to determine the optimal length of multidomain interventions.

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Section: Discussionsupporting

confidence: 64%

“… 16 , 17 Additionally, reviews on this topic have primarily focused on memory or are limited to investigations of cognitive and physical training, while interventions such as mindfulness and nutrition are overlooked. 17 , 18 , 19 …”

Section: Introductionmentioning

confidence: 99%

Associations of Multidomain Interventions With Improvements in Cognition in Mild Cognitive Impairment

et al. 2022

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“…In addition, physical activity yields significant improvements in cognition in individuals with dementia and mild cognitive impairment [81][82][83]. Interestingly a recent meta-analysis of randomized controlled trials has shown that combining cognitive intervention and physical exercise results in superior benefits over either intervention alone on global cognition, memory, executive function, and attention in older adults with mild cognitive impairment [84].…”

Section: Rehabilitation Strategiesmentioning

confidence: 99%

The Impact of COVID-19 Infection on Cognitive Function and the Implication for Rehabilitation: A Systematic Review and Meta-Analysis

Houben

Bonnechère

2022

IJERPH

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There is mounting evidence that patients with severe COVID-19 disease may have symptoms that continue beyond the acute phase, extending into the early chronic phase. This prolonged COVID-19 pathology is often referred to as ‘Long COVID’. Simultaneously, case investigations have shown that COVID-19 individuals might have a variety of neurological problems. The accurate and accessible assessment of cognitive function in patients post-COVID-19 infection is thus of increasingly high importance for both public and individual health. Little is known about the influence of COVID-19 on the general cognitive levels but more importantly, at sub-functions level. Therefore, we first aim to summarize the current level of evidence supporting the negative impact of COVID-19 infection on cognitive functions. Twenty-seven studies were included in the systematic review representing a total of 94,103 participants (90,317 COVID-19 patients and 3786 healthy controls). We then performed a meta-analysis summarizing the results of five studies (959 participants, 513 patients) to quantify the impact of COVID-19 on cognitive functions. The overall effect, expressed in standardized mean differences, is −0.41 [95%CI −0.55; −0.27]. To prevent disability, we finally discuss the different approaches available in rehabilitation to help these patients and avoid long-term complications.

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“…Nicht ganz so neu dagegen sind die Erkenntnisse zur Rolle der körperlichen Aktivität bei der Neurogenese: „The discovery that exercise regulates adult hippocampal neurogenesis, that is, the production of new neurons in the adult brain, was surprising news and changed quite fundamentally our view on how physical activity affects the brain.“ 21 Diese Erkenntnisse werden auch konkret für die Entwicklung von Bewegungsprogrammen genutzt (z. B. Meng et al 2021 22 ).…”

Section: Bewegung Als Pille Mit Pleiotroper Wirkungunclassified

Bewegungstherapie 2.0

Huber

2022

B&G Bewegungstherapie und Gesundheitssport

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ZusammenfassungFür die meisten chronischen Erkrankungen hat unter allen medizinischen Interventionen die körperliche Aktivität das beste Verhältnis von Risiko und Nutzen und wahrscheinlich auch das beste Kosten-Nutzen-Verhältnis. Leider wird diese Option im Gesundheitssystem noch viel zu wenig genutzt. Körperliche Aktivität ist für die Gesundheit des Menschen systemrelevant; ist aber nur unzureichend in das System der Gesundheitsversorgung integriert. Es ist deshalb notwendig, die traditionellen Konzepte zu erweitern und neue Perspektiven für die Bewegungstherapie zu eröffnen. Dabei geht es um die Frage, wie und warum Bewegung und körperliche Aktivität wirken und wie bewegungsbezogene Interventionen zu differenzieren sind. Neuere Forschungen zeigen, dass für die körperliche Aktivität z. B. auf der Ebene der Exerkine weitaus mehr Wirkmechanismen für die Gesundheitseffekte verantwortlich sind als bisher angenommen. Das erweiterte Spektrum der Wirkmechanismen kann u. a. die Grundlage dafür bilden, die Konzepte für die Bewegungsförderung und die Bewegungstherapie weiterzuentwickeln. Der Beitrag soll Anstöße für die dazu notwendige Diskussion liefern, bei der der Bewegungswissenschaft eine tragende Rolle zukommt.

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The effect of combined cognitive intervention and physical exercise on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials

Cited by 34 publications

References 46 publications

Associations of Multidomain Interventions With Improvements in Cognition in Mild Cognitive Impairment

Associations of Multidomain Interventions With Improvements in Cognition in Mild Cognitive Impairment

The Impact of COVID-19 Infection on Cognitive Function and the Implication for Rehabilitation: A Systematic Review and Meta-Analysis

Bewegungstherapie 2.0

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