The Effect of Combined Ezetimibe/Atorvastatin Therapy vs. Atorvastatin Monotherapy on the Erythrocyte Membrane Structure in Patients with Coronary Artery Disease: A Pilot Study

Jackowska, Paulina; Pytel, Edyta; Koter−Michalak, Maria; Olszewska-Banaszczyk, Małgorzata; Legęza, Aleksandra; Broncel, Marlena

doi:10.17219/acem/34791

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Coronary heart disease (CHD) is a common kind of heart disease in which atherosclerotic pathological changes in the coronary arteries cause vascular obstruction or lumen stenosis, resulting in hypoxia and ischemic necrosis of myocardial tissue and hereby affecting heart function [ 1 ]. It is characterized by chest distress and chest pain, which are aggravated after activities and this condition is more prevalent among people over 40 years old, but recent years have witnessed an increased morbidity among young people with the improvement of people's material living standards and lifestyle changes [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidation Function of EGCG by Activating Nrf2/HO‐1 Pathway in Mice with Coronary Heart Disease

Huang

Chao

Ren

et al. 2022

Contrast Media & Molecular Imaging

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Objective. To explore the effect and mechanism of epigallocatechin gallate (EGCG) in mice with coronary heart disease (CHD). Methods. Firstly, a CHD model of mouse was established by feeding mice high-fat diet and randomly divided into four groups, including Model group (0.5% sodium cholate) and 10 mg/kg EGCG, 20 mg/kg EGCG, and 40 mg/kg EGCG groups. After oral administration of sodium cholate or EGCG, HE staining was conducted to assess the pathological changes of mouse cardiac tissues in each group of mice, biochemical kits to measure the levels of blood lipid and oxidative stress substance activity, and western blot to detect matrix metalloproteinase 2 (MMP-2), vascular endothelial growth factor (VEGFA), as well as expression levels of protein related to Nrf2/HO-1/NQO1 pathway in cardiac tissues. Results. The mice in the CHD model appeared to have myocardial pathological damage with elevated serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and decreased high-density lipoprotein cholesterol (HDL-C). Of note, administration of EGCG significantly attenuated myocardial injuries and improved blood lipid levels in mice in a concentration-dependent manner. The advent of EGCG significantly decreased the expression of VEGFA and MMP-2 and increased the activity of superoxide dismutase (SOD), when reducing the content of reactive oxygen species (ROS) in the myocardial tissue and upregulating the expression of HO-1, NQO1, and Nrf2. Conclusion. EGCG may reduce atherosclerotic plaque and alleviate pathological damage in the cardiac tissue of CHD mice as well as improve blood lipid levels with antioxidative effect. The mechanism of its effect may be related to the activation of the Nrf2/HO-1/NQO1 antioxidant pathway in vivo of the CHD mice.

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Section: Introductionmentioning

confidence: 99%

Antioxidation Function of EGCG by Activating Nrf2/HO‐1 Pathway in Mice with Coronary Heart Disease

Huang

Chao

Ren

et al. 2022

Contrast Media & Molecular Imaging

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“…Similarly, simvastatin was reported to decrease lipid peroxidation of erythrocyte membranes [ 109 ]. Lipid-lowering therapy with atorvastatin combined with ezetimibe or atorvastatin alone has also been shown to improve erythrocyte membrane parameters in patients with coronary artery disease [ 110 ].…”

Section: Factors Affecting the Lifespan Of Erythrocytesmentioning

confidence: 99%