The effect of combined hyperbaric oxygen and iloprost treatment on the prevention of spinal cord ischaemia–reperfusion injury: an experimental study

Abstract

Since we demonstrated beneficial effects on spinal cord IR injury, we think that both HBO and IL, either alone or in combination, may be reasonable in the treatment of IR injury. Furthermore, there did not appear to be synergistic effects with combined treatment. More research is needed for practical application in humans, following thoracoabdominal aortic surgery.

Centrally acting drug moxonidine decreases reactive oxygen species via inactivation of the phosphoinositide-3 kinase signaling in the rostral ventrolateral medulla in hypertensive rats

“…Third, it is not clear whether nitric oxide is involved in antioxidant effect of moxonidine. As an antioxidant, nitric oxide is involved in neural control of the cardiovascular function [52,53]. An imbalance between nitric oxide and nitric oxide contributes to the pathophysiological process of cardiovascular diseases.…”

The administration of neurocytoprotectors in a rat model of experimental spinal cord ischemia

“…За последние годы в условиях экспериментальной миелоишемии был доказан положительный эффект агонистов аденозиновых А2а-рецепторов, ингибиторов NMDA-рецепторов, эритропоэтина и его производных [14], факторов роста нервной ткани [15] и стволовых мезенхимальных клеток [14][15][16]. Миелопротективный эффект наблюдался в условиях умеренной гипотермии [16,17] и гипербарической оксигенации [18].…”

Delayed Incomplete Paraplegia After En Bloc Spondylectomy of Thoracic Metastasis, A Case Report

“…Before operation, preconditioning hyperbaric oxygen can induce tolerance of spinal cord against ischemia and attenuate early apoptosis of spinal cord cells by upregulation of antioxidant enzymes, which was veri ed in rabbits and rats [28][29]. To speak of the rehabilitation measures, hyperbaric oxygen treatment may play a role in function recovery of spinal cord after ischemia [30]. About this case, hyperbaric oxygen treatment was started 3 days after operation, 90 minutes each day, and obvious improvements of both lower limbs' power could be seen (from ASIA B to D), while it still needs more data to evaluate its effectiveness on spinal cord ischemia.…”