The effect of combined polymorphisms in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a Brazilian population

Vieira, Valdimara Corrêa; Barral, Maria Fernanda Martínez; Mendoza-Sassi, Raúl Andrés; Silveira, Jussara María; Soares, Marcelo A.; Martínez, Ana Maria Barral de

doi:10.1590/s0074-02762011000400005

Cited by 10 publications

(9 citation statements)

References 62 publications

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“…In other populations such as Brazilian, Hungarian, Chinese, Polish, and Indian, the distribution of this variant ranges between 14% and 40%. [23][24][25][26][27][28] Thus, distribution of this variant in the Jordanian population is within the range described in other countries.…”

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confidence: 87%

“…29,30 On the other hand, lack of association with this polymorphism has been reported in Polish and Spanish populations. 31,32 Similarly, an association between the CCR2-64I polymorphism and progression to AIDS has been shown in Brazilian and Chinese populations 23,33 but not in Georgian and Kenyan populations. 34,35 For SDF1-3¢A, controversial associations with this polymorphism hves been reported.…”

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confidence: 98%

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Distribution OfCCR-5Δ32,CCR2-64I, andSDF-1-3′AAlleles Among Jordanians

Khabour

Abu-Haweleh²,

Alzoubi³

2013

AIDS Research and Human Retroviruses

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Entry of HIV virus into cells is mediated by chemokine receptors. Genetic variations in chemokine receptors have been shown to modulate susceptibility to HIV infection and disease course. In this study, the frequencies of CCR5 (CCR5-Δ32), CCR2 (CCR2-64I), and SDF-1 (SDF-1-3') gene polymorphisms were determined in a Jordanian population. A total of 540 subjects were randomly selected from different regions of Jordan (South, Middle, and North). Six individuals were found to carry the CCR5-Δ32 allele (0.6%) and only in the heterozygous genotype. The frequencies of CCR2-64I and SDF1-3'A were 17.5% and 34.2%, respectively. In addition, no significant difference in the distribution of the examined polymorphisms among different regions of Jordan was detected. In conclusion, the CCR5-Δ32 allele is rare, whereas the CCR2-64I and SDF1-3'A alleles are common among Jordanians.

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confidence: 87%

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confidence: 98%

Distribution OfCCR-5Δ32,CCR2-64I, andSDF-1-3′AAlleles Among Jordanians

Khabour

Abu-Haweleh²,

Alzoubi³

2013

AIDS Research and Human Retroviruses

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“…, 0.6% in Cepem, 0.7% in African-Brazilian populations from Pará (Carvalhaes et al , 2004), 0.9 and 1.0% in Bahia (Carvalho et al , 2004), 1.8% in Candelária and Bate-Estaca and 1.9% and 2.0% in African-Brazilian individuals in Rio de Janeiro (Chies and Hutz, 2003) and Paraná (Boldt et al , 2009), respectively. Among HIV + subjects, frequencies ranged from 2.1% in Rio de Janeiro (Teixeira et al , 2009) to 2.4% in Rio Grande do Sul (Vieira et al , 2011), 2.6% in a miscegenated population in Bahia (Grimaldi et al , 2002) and 3.8% in São Paulo (Rigato et al , 2008). Hünemeier et al (2005) found frequencies of 2.0 and 3.0% in Amerindian populations from south Brazil.…”

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confidence: 99%

Distribution of the CCR5delta32 allele (gene variant CCR5) in Rondônia, Western Amazonian region, Brazil

Farias¹,

Santos

França

et al. 2012

Genet. Mol. Biol.

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Since around 1723, on the occasion of its initial colonization by Europeans, Rondonia has received successive waves of immigrants. This has been further swelled by individuals from northeastern Brazil, who began entering at the beginning of the twentieth century. The ethnic composition varies across the state according to the various sites of settlement of each wave of immigrants. We analyzed the frequency of the CCR5Δ32 allele of the CCR5 chemokine receptor, which is considered a Caucasian marker, in five sample sets from the population. Four were collected in Porto Velho, the state capital and the site of several waves of migration. Of these, two, from the Hospital de Base were comprised of HB Mothers and HB Newborns presenting allele frequencies of 3.5% and 3.1%, respectively, a third from the peri-urban neighborhoods of Candelária/Bate-Estaca (1.8%), whereas a fourth, from the Research Center on Tropical Medicine/CEPEM (0.6%), was composed of malaria patients under treament. The fifth sample (3.4%) came from the inland Quilombola village of Pedras Negras. Two homozygous individuals (CCR5Δ32/CCR5Δ32) were detected among the HB Mother samples. The frequency of this allele was heterogeneous and higher where the European inflow was more pronounced. The presence of the allele in Pedras Negras revealed European miscegenation in a community largely comprising Quilombolas.

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“…Previous studies indicated a relation between CCR2V64Il, a variant of CCR2, and some inflammatory and autoimmune diseases such as coronary artery disease, diabetes mellitus, progression of HIV, chronic renal failure, and trigeminal neuralgia [8, 11, 27, 28]. These studies showed that CCR2 polymorphism plays a role in CAD and myocardial infarction pathogenesis by vessels inflammation and produced atherosclerotic plaque [8, 29].…”

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confidence: 99%

Investigation of Chemokine Receptor CCR2V64Il Gene Polymorphism and Migraine without Aura in the Iranian Population

Zandifar

Taheriun

Soleimani

et al. 2013

The Scientific World Journal

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Background and Objectives. Migraine is a multifactorial common neurovascular disease with a polygenic inheritance. Inflammation plays an important part in migraine pathophysiology. C-C chemokine receptor 2 (CCR2) is an important chemokine for monocyte aggregation and transendothelial monocyte migration. The aim of our study was to investigate the association of migraine with CCR2V64Il polymorphism in the Iranian population. Methods. We assessed 103 patients with newly diagnosed migraine and 100 healthy subjects. Genomic DNA samples were extracted from peripheral blood and genotypes of CCR2V64Il gene polymorphism were determined. For measuring the severity of headache, every patient filled out the MIGSEV questionnaire. Results. There were no significant differences in the distribution of both 64Il allele and heterozygote (GA) genotype of CCR2 gene polymorphism (P = 0.396; OR = 0.92, 95% CI = 0.50–1.67 and P = 0.388; OR = 0.91, 95% CI = 0.47–1.73, resp.) between case and control groups. There was no significant difference of alleles frequency between three grades of MIGSEV (P = 0.922). Conclusions. In conclusion our results revealed no association between CCR2V64Il polymorphism and susceptibility to migraine and also headache severity in the Iranian population.

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The effect of combined polymorphisms in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a Brazilian population

Abstract: Polymorphisms in genes that encode chemokines or their receptors can modulate susceptibility to human immunodeficiency virus (HIV) infection and disease progression. The objective of this study was to assess the frequency of polymorphisms

Cited by 10 publications

References 62 publications

Distribution OfCCR-5Δ32,CCR2-64I, andSDF-1-3′AAlleles Among Jordanians

Distribution OfCCR-5Δ32,CCR2-64I, andSDF-1-3′AAlleles Among Jordanians

Distribution of the CCR5delta32 allele (gene variant CCR5) in Rondônia, Western Amazonian region, Brazil

Investigation of Chemokine Receptor CCR2V64Il Gene Polymorphism and Migraine without Aura in the Iranian Population

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