The effect of comorbidity on hospital mortality in patients with SLE from an Asian tertiary hospital

Abstract

The SLE burden is high in this population. Comorbidities and infectious disease were some of the most important contributors to hospital mortality and resource utilization.

Good prognosis for hospitalized SLE patients with non-related disease

“…This finding is similar to our group of patients, but infections were not serious as reported in other studies [17]. Furthermore, hospitalized lupus patients are more prone to develop nosocomial infections which are not related to steroid use [19].…”

“…In a study performed in an ambulatory setting, the CCI in SLE patients correlated with decreased survival independent of age, lupus disease activity, and damage accrual [23]. Also in a hospitalized setting, a high CCI score was associated with mortality in SLE patients [19].…”

“…The mortality rate was 3% for SLE patients that were hospitalized for exacerbations or other causes directly related to the disease or immunosuppression [12,18] compared to our study population with non-related causes where a mortality rate of 1% was found and even less than the control non-SLE group. In a study aimed at general causes for hospitalization to an internal medicine ward that were not lupus exacerbations, in 4840 SLE patients, identification of increased mortality risk was associated with the Charlson score, respiratory failure, SLE co-morbidity index, age, sepsis, nephritis, and thrombocytopenia [19]. In a retrospective study of 76,961 files from lupus patients, hospitalizations were expensive and extensive, with increased mortality especially in the first week, when compared to the non-lupus population [12].…”

Management of Patients with Systemic Lupus Erythematosus at the Stage of Primary Care: Answers to Frequently Asked Questions

“…СКВ часто отягощена различными коморбидными состояниями (сердечно-сосудистые заболевания, метаболический синдром, злокачественные новообразования, инфекции и остеопороз) [23]. Сопутствующие заболевания оказывают негативное влияние на качество жизни, трудоспособность и выживаемость пациентов с СКВ, приводя к неэффективности патогенетического лечения, увеличению числа госпитализаций и затрат здравоохранения для таких пациентов [71]. У мужчин с СКВ чаще встречаются сердечно-сосудистые заболевания/инсульт и рак.…”

Lupus around the world

“…The numbers are striking, including a series of 2684 patients from China, 1 9349 from Taiwan, 2 (also from Taiwan a staggering series of 2870 admitted to intensive care over a period of nine years), 3 1521 from Korea, 4 841 from Singapore, 5 and 428 from two centres in Turkey. 6 There were of course, similarities-the almost universal 9:1 female to male ratio-and differences between the series.…”