The effect of compressive loading rate on annulus fibrosus strength following endplate fracture

McMorran, John G.; Gregory, Diane E.

doi:10.1016/j.medengphy.2021.05.010

Cited by 9 publications

(2 citation statements)

References 47 publications

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“…The peel test in the current study aims to quantify the tensile strain in the ILM when resisting delamination (Gregory et al, 2012). A limited number of studies have reported adhesion strength and variability in the AF including in the bovine tail (Harvey-Burgess and Gregory, 2019), rabbit (Gregory et al, 2014), porcine (Snow et al, 2018;Ghelani et al, 2020;McMorran and Gregory, 2021), and human (Calvo-Echenique et al, 2018) IVD. The peel strength values reported in the current study are similar to those reported previously in the bovine tail and porcine; while the reported values in the rabbit and human IVD were much lower (less than 1.0N/mm); however this may be a result of the high degree of degeneration in those experiments.…”

Section: Discussionmentioning

confidence: 99%

Delamination of the Annulus Fibrosus of the Intervertebral Disc: Using a Bovine Tail Model to Examine Effect of Separation Rate

Briar

McMorran

Gregory

2022

Front. Bioeng. Biotechnol.

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The intervertebral disc (IVD) is a complex structure, and recent evidence suggests that separations or delamination between layers of the annulus may contribute to degeneration development, a common cause of low back pain The purpose of the present experiment was to quantify the mechanical response of the layer-adjoining interlamellar matrix at different rates of separation. Understanding the rate-dependency of the interlamellar matrix, or the adhesion between adjacent layers of the disc, is important as the spine experiences various loading velocities during activities of daily living. Twelve discs were dissected from four bovine tails (three extracts per tail). Two multi-layered annulus samples were collected from each IVD (total = 24, mean bond width = 3.82 ± 0.96 mm) and randomly assigned to a 180° peel test at one of three delamination rates; 0.05 mm/s, 0.5 mm/s, or 5 mm/s. Annulus extracts were found to have similar maximal adhesion strengths (p = 0.39) and stiffness (p = 0.97) across all rate conditions. However, a significant difference in lamellar adhesion strength variability was observed between the 5 mm/s condition (0.96 N/mm ± 0.31) when compared to the 0.5 mm/s (0.50 N/mm ± 0.19) and 0.05 mm/s (0.37 N/mm ± 0.13) conditions (p < 0.05). Increased variability may be indicative of non-uniform strength due to inconsistent adhesion throughout the interlamellar matrix, which is exacerbated by increased rates of loading. The observed non-uniform strength could possibly lead to a scenario more favourable to the development of microtrauma, and eventual delamination.

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Section: Discussionmentioning

confidence: 99%

Delamination of the Annulus Fibrosus of the Intervertebral Disc: Using a Bovine Tail Model to Examine Effect of Separation Rate

Briar

McMorran

Gregory

2022

Front. Bioeng. Biotechnol.

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“…The etiology of LBP is multifactorial, and the major contributor is considered to be intervertebral disc degeneration (IDD) [4][5][6][7][8]. The risk factors of IDD mainly include age [9], genetic predisposition [10][11][12], mechanical damage [13], high body mass index, obesity [14] and so on [15]. Current therapeutic strategies for IDD contain conservative and surgical options, but the outcomes are not invariable pleased [16].…”

Section: Introductionmentioning

confidence: 99%

Insights into Exosome in the Intervertebral Disc: Emerging Role for Disc Homeostasis and Normal Function

Zhao¹,

Xu²,

Duan³

et al. 2022

Int. J. Med. Sci.

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Low back pain (LBP) is a chronic condition that causes great individual suffering and economic burden. The major contributor of LBP is intervertebral disc degeneration (IDD), which is caused by a spectrum of homeostasis alteration, including the apoptosis of nucleus pulposus (NP) and annulus fibrosus (AF) cells, degradation of extracellular matrix (ECM), calcification of cartilaginous endplates (CEP) and so on. Currently, the therapeutic strategy for IDD includes conservative and surgery treatment. Nevertheless, none of them could reverse the progressive destruction of the intervertebral disc. Hence, it is pivotal to pursue a new therapeutic approach. Exosomes, nano-sized substances with diameters of 30-150 nm, can be synthesized and secreted by various types of cells. They play an important role in intercellular communication. Increasing evidence implicates that exosomes could impact the intracellular transcription activities, thereby inhibiting or accelerating the proliferation and apoptosis of cells. Thus, it is a new therapeutic source for IDD. This review chiefly focuses on generalizing and clarifying the roles of exosomes in the onset and deterioration of IDD, and their therapeutic potential.

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Combined flexion and compression negatively impact the mechanical integrity of the annulus fibrosus

Briar

Gregory

2023

Eur Spine J

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The effect of compressive loading rate on annulus fibrosus strength following endplate fracture

Cited by 9 publications

References 47 publications

Delamination of the Annulus Fibrosus of the Intervertebral Disc: Using a Bovine Tail Model to Examine Effect of Separation Rate

Delamination of the Annulus Fibrosus of the Intervertebral Disc: Using a Bovine Tail Model to Examine Effect of Separation Rate

Insights into Exosome in the Intervertebral Disc: Emerging Role for Disc Homeostasis and Normal Function

Combined flexion and compression negatively impact the mechanical integrity of the annulus fibrosus

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