The effect of conduction velocity slowing in left ventricular midwall on the QRS complex morphology: A simulation study

Bachárová, Ljuba; Szathmary, Vavrinec; Svehlikova, Jana; Mateášik, Anton; Gyhagen, Julia; Tyšler, Milan

doi:10.1016/j.jelectrocard.2015.12.009

Cited by 17 publications

(11 citation statements)

References 47 publications

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“…In the absence of fixed slow depolarization, eg bundle branch block, the depolarization wave length is determined by myocardial thickness which is known to have mid‐thickness fibrosis that itself adds to the slow conduction, as shown experimentally . Our observations mirror those findings and further explain them.…”

Section: Discussionsupporting

confidence: 83%

“…45 In the absence of fixed slow depolarization, eg bundle branch block, the depolarization wave length is determined by myocardial thickness which is known to have mid-thickness fibrosis that itself adds to the slow conduction, as shown experimentally. 11,33,36,46 Our observations mirror those findings and further explain them. The slow depolarization due to increased LV mass increases the signal amplitude, hence the enlarged QRS area which showed, in our patients, the highest relationship with LV mass.…”

Section: Data Interpretationsupporting

confidence: 90%

“…The QRS complex reflects the time and speed of myocardial depolarization which is related to LV structure much more than function . The myocardium requires coherent electric stimulation to guarantee efficient mechanical function.…”

Section: Discussionmentioning

confidence: 99%

“…The QRS complex reflects the time and speed of myocardial depolarization which is related to LV structure much more than function. 1,7,[32][33][34][35][36] The myocardium requires coherent electric stimulation to guarantee efficient mechanical function. In the population we studied, both LV morphology and function influenced the QRS complex measurements, its duration prolongs and amplitude rises as muscle mass increases irrespective of ejection fraction.…”

Section: Data Interpretationmentioning

confidence: 99%

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Relationship between QRS measurements and left ventricular morphology and function in asymptomatic individuals

Vancheri¹,

Vancheri²,

Henein

2017

Echocardiography

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Section: Discussionsupporting

confidence: 83%

Section: Data Interpretationsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Data Interpretationmentioning

confidence: 99%

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Relationship between QRS measurements and left ventricular morphology and function in asymptomatic individuals

Vancheri¹,

Vancheri²,

Henein

2017

Echocardiography

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“…Following which the impulse conduction is via the bundle of HIS conduction system and into the ventricular myocardium. Ventricular activation is responsible for the generation of the ECG derived QRS complex [2]. S-A node activation and cardiac autonomic contributions to the SA-node are typically studied via electrocardiogram (ECG) derived R–R intervals (around a mean value), using heart rate variability (HRV) [3, 4].…”

Section: Introductionmentioning

confidence: 99%

Systolic blood pressure but not electrocardiogram QRS duration is associated with heart rate variability (HRV): a cross-sectional study in rural Australian non-diabetics

2017

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BackgroundA positive correlation between ECG derived QRS duration and heart rate variability (HRV) parameters had previously been reported in young healthy adults. We note this study used a narrow QRS duration range, and did not adjust for systolic blood pressure. Our aims are to investigate associations between systolic blood pressure (SBP), QRS duration and HRV in a rural aging population.MethodsA retrospective cross sectional population was obtained from the CSU Diabetes Screening Research Initiative data base where 200 participants had no diabetes or pre-diabetes. SBP data were matched with ECG derived QRS duration and HRV parameters. HRV parameters were calculated from R-R intervals. Resting 12-lead electrocardiograms were obtained from each subject using a Welch Allyn PC-Based ECG system.ResultsPearson correlation analysis revealed no statistically significant associations between HRV parameters and QRS duration. No significant mean differences in HRV parameter subgroups across defined QRS cut-offs were found. SBP > 146 mmHg was associated with increasing QRS durations, however this association disappeared once models were adjusted for age and gender. SBP was also significantly associated with a number of HRV parameters using Pearson correlation analysis, including high frequency (HF) (p < 0.05), HFln (p < 0.02), RMSDD (p < 0.02) and non-linear parameters; ApEN (p < 0.001) were negatively correlated with increasing SBP while the low frequency to high frequency ratio (LF/HF) increased with increasing SBP (p < 0.03).ConclusionsOur results do not support associations between ECG derived R-R derived HRV parameters and QRS duration in aging populations. We suggest that ventricular conduction as determined by QRS duration is independent of variations in SA-node heart rate variability.

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Findings relevant to the QRS wave in the resting electrocardiogram are associated with circulating concentrations of high-sensitivity cardiac troponin I in the general population

Sugiura

Dohi

Takase

et al. 2018

Journal of the American Society of Hypertension

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The effect of conduction velocity slowing in left ventricular midwall on the QRS complex morphology: A simulation study

Cited by 17 publications

References 47 publications

Relationship between QRS measurements and left ventricular morphology and function in asymptomatic individuals

Relationship between QRS measurements and left ventricular morphology and function in asymptomatic individuals

Systolic blood pressure but not electrocardiogram QRS duration is associated with heart rate variability (HRV): a cross-sectional study in rural Australian non-diabetics

Findings relevant to the QRS wave in the resting electrocardiogram are associated with circulating concentrations of high-sensitivity cardiac troponin I in the general population

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