The effect of conjugated linoleic acid on oxidative stress and matrix metalloproteinases 2 and 9 in patients with COPD

Abstract

BackgroundNatural antioxidants in foods may be used in prevention and treatment of oxidative stress and inflammation in COPD. Therefore, this study aimed to evaluate the effect of conjugated linoleic acid (CLA) supplement as natural antioxidants on oxidative stress levels, and MMP2 and MMP9 serum levels in COPD patients.Materials and methodsThis clinical trial study was conducted on 90 (supplement group=45 and control group=45) COPD patients in Ardabil city, Iran, in 2015. After obtaining written consent, general information was collected from each patient using a validated and reliable questionnaire. Supplement group received 3.2 g of CLA and those in the control group were given 3.2 g of placebo for 6 weeks on a daily basis. Fasting blood samples were taken from all of the patients for testing of malondialdehyde (MDA), MMP2, and MMP9 levels at the beginning and end of the study. Data were analyzed using Kolmogorov–Smirnov test, independent samples t-test, paired sample t-test, chi-square test, and ANOVA.ResultsThere were no significant differences between the two groups with regard to mean age, smoking status, and serum level of MDA at the beginning of the study. In the supplement group, the serum level of MDA decreased significantly at the end of the 6th week compared to that in the beginning of the study (p=0.0004), while in the placebo group, the difference was found to be insignificant. The serum level of MMP9 decreased significantly in the supplement group, while in the placebo group its level increased significantly as compared to that at the beginning of the study (p<0.05). The serum levels of MMP2 indicated no significant differences between the two groups neither at the beginning nor at the end of the study.ConclusionThese findings indicated that CLA supplementation may be helpful for COPD patients through inhibiting the production of oxidative stress and controlling MMP9 serum levels.

Fatty acids, health indices and sensory properties of Ricotta cheese from sheep fed three different diets

“…Oleic acid levels were significantly higher in Ricotta from the L‐group than in Ricotta from the P‐group ( P < 0.005), and the content was lowest in Ricotta from the group of sheep fed a typical milking ration. This result is valuable because CLA is recognised as beneficial for human health, by combating oxidative stress (Matin et al ).…”

The Impacts of Ramadan Intermittent Fasting on Oxidant/Antioxidant Stress Biomarkers of Stable Chronic Obstructive Pulmonary Disease Male Patients

“…Third, it was desirable to assess the COPD patients’ nourishment. In fact, dietary aberrations could influence the OS/AOS biomarkers (Lu et al, 2018; Matin, Nemati, Ghobadi, Alipanah-Moghadam, & Rezagholizadeh, 2018). For example, it was demonstrated that oligomeric proanthocyanidins supplementation was effective in increasing the AOS capacity in patients with COPD (Lu et al, 2018).…”

Feverfew attenuates carbon tetrachloride-induced testicular damage in rats

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