1990
DOI: 10.1113/expphysiol.1990.sp003397
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The effect of continued feeding of physiological amounts of lactose on the level of intestinal lactase and other disaccharidase enzyme activities in the rat

Abstract: SUMMARYIntestinal lactase activity in mammals is high at birth but begins to decline around weaning and reaches very low levels in adult life. The triggering mechanism for this decline is not clear. Because of the association of the decline with weaning, lack of lactose in the diet has been implicated. In 110 growing rats, the effect of continued supplementation of the diet after weaning with physiological amounts of either cows' milk or a 5 % lactose solution on intestinal lactase and other disaccharidase enz… Show more

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Cited by 5 publications
(7 citation statements)
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“…We confirm and observed a major decline in lactase activity during development, although not to the extent as found previously, i.e. , to 5%–10% of its original level [ 1 , 15 , 16 ]. Hence, residual lactase activity was shown to be present in adulthood and was confirmed to be functional by a small rise in plasma glucose levels upon lactose intake, as also shown by others [ 4 , 17 , 18 ].…”
Section: Discussionsupporting
confidence: 88%
“…We confirm and observed a major decline in lactase activity during development, although not to the extent as found previously, i.e. , to 5%–10% of its original level [ 1 , 15 , 16 ]. Hence, residual lactase activity was shown to be present in adulthood and was confirmed to be functional by a small rise in plasma glucose levels upon lactose intake, as also shown by others [ 4 , 17 , 18 ].…”
Section: Discussionsupporting
confidence: 88%
“…They also show that galactose at the dosage used here had no effect on the pattem of development of the other disaccharidases. These findings are in agreement with investigations where there was prolonged suckling, or provision of supplementary milk or lactose to the diet of growing animals (Lebenthal, Sunshine & Kretchmer, 1973;Tadesse, 1990). The results also corroborate the finding of Kogut, Donnel & Shaw (1967), who totally excluded milk and milk products from the diets of galactosaemic children for many years without effect (i.e.…”
Section: Resultssupporting
confidence: 91%
“…It also has no appreciable effect on the development of the other disaccharidase enzymes. The present results, in conjunction with other findings using lactose or milk (Tadesse, 1990), suggest that a dietary shift is unlikely to play a central role in the initiation and maintenance of the decline in lactase activity.…”
Section: Resultssupporting
confidence: 78%
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“…The activities of lactase and sucrase were decreased in pigs that were fed partially hydrolysed rice syrup on day 21, which suggests that the diet could affect disaccharidase activity. Tadesse20 reported that lactase activity in adult mammals might be inducible. In the current study the specific activity of lactase was highest in the jejunum.…”
Section: Discussionmentioning
confidence: 99%