The effect of corticosteroid-induced osteoporosis on orthodontic tooth movement

Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid

“…Similarly, previous studies that evaluated the effects of systemic-osteoporotic hormonal imbalance on orthodontic tooth movement showing the increased rate of orthodontic tooth movement in the osteoporotic alveolar bone due to the effects of OVX have influenced on the increase of the bone turnover resulting in the acceleration of orthodontic tooth movement. 36,37 Furthermore, the OVX was reported to increase the indices of the bone resorption in the rat tibia at 2 weeks after OVX, and the maximal increase in the bone resorption parameters consequently occurred in the few months. 38 The theories of root resorption have been clarified via several molecular and cellular mechanisms to exemplify the pathways of root resorption.…”

Elevation of a full-thickness mucoperiosteal flap alone accelerates orthodontic tooth movement

“…A similar study by Ashcraft et al, 45 assessed the effects of osteoporosis on tooth movement. Using sixteen New Zealand white rabbits, experimental rabbits received cortisone acetate to induce osteoporosis while control rabbits received no such pharmacologic intervention.…”

Osteoporosis and Orthodontics: A Review

“…The osteoblastic and osteoclastic function is directly inhibited by corticosteroid. [29][30][31] Ashcraft et al, [32] found that corticosteroid administered rabbits had elevated osteoclastic activity, increased alveolar bone resorption, and suppressed bone deposition, which accelerate tooth movement with subsequent greater relapse. Verna et al, [33] found more root resorption in an acute corticosteroid treatment group when compared with the control and a chronic group and at the same time reduces bone turnover.…”