The effect of corticotropin (ACTH) and cortisone on idiopathic thrombocytopenic purpura

Wilson, Sloan J.; Eisemann, Gustave

doi:10.1016/0002-9343(52)90077-6

Cited by 28 publications

(3 citation statements)

References 12 publications

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“…This may lead to variable bleeding symptoms ranging from mild bruising to, in rare cases, life‐threatening haemorrhage. In most patients, bleeding is successfully controlled by corticosteroid therapy, which since 1958 (1, 2) has remained the initial treatment of choice. Spontaneous remissions are rarely observed in this patient population (3, 4).…”

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confidence: 99%

Response to splenectomy is durable after a certain point in time in adult patients with chronic immune thrombocytopenic purpura

Johansson

Engervall

Landgren

et al. 2006

European J of Haematology

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Splenectomy may lead to a good response in 60-80% of adult patients with corticosteroid refractory idiopathic thrombocytopenic purpura (ITP) but, the long-term response to splenectomy still remains less well defined. We assessed the long-term efficacy and safety of splenectomy in adult patients with chronic ITP. A cohort of 59 splenectomised ITP patients (M/F = 25/34; median age 39 yr; range 14-75) were followed up for a median of 18 yr (range 2-32). No life-threatening surgical complications were observed. The overall response rate was 78% with 59% complete remission (CR) and 19% partial remission (PR). CR and PR patients were younger than non-responding patients at time of diagnosis (median age: 36 yr vs 48 yr, P = 0.03) and at splenectomy (median age: 38 yr vs 51 yr, P = 0.02). Among the 46 responding patients, eventually 17 had relapse. No disease progression occurred after 12.1 and 7.3 yr for patients in CR or PR, respectively. One case of fatal septicaemia was recorded. We conclude that splenectomy is an effective and safe treatment in adult patients with chronic ITP failing to respond to corticosteroid treatment and importantly, our findings support the view that response to splenectomy is durable after a certain point in time.

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confidence: 99%

Response to splenectomy is durable after a certain point in time in adult patients with chronic immune thrombocytopenic purpura

Johansson

Engervall

Landgren

et al. 2006

European J of Haematology

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“…In view of the value of A.C.T.H. and cortisone in idiopathic thrombocytopenic purpura (Bethell et al, 1951;Wilson and Eisemann, 1952;Faloon et al, 1952) and in other varieties of toxic reaction to drugs (Steinberg and Roodenburg, 1951), it was decided to explore their value in this condition. A total of 100 mg. of A.C.T.H.…”

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confidence: 99%

Thrombocytopenic Purpura After Administration of Gold

Thompson¹,

Sinclair²,

Duthie³

1954

BMJ

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“…It is possible that corticotropin and cortisone affect an unknown immunothrombocytopenic mechanism. 8 Postoperative wound hemorrhage due to thrombocytopenia may be treated con¬ servatively with supportive therapy and repeated fresh blood transfusions if the bleeding is not severe. Cortisone and corticotropin may prove to be adjuncts in this treatment.…”

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confidence: 99%

Massive Postoperative Hemorrhage Due to Unrecognized Thrombocytopenia

McLaughlin¹

1954

Arch Surg

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The effect of corticotropin (ACTH) and cortisone on idiopathic thrombocytopenic purpura

Cited by 28 publications

References 12 publications

Response to splenectomy is durable after a certain point in time in adult patients with chronic immune thrombocytopenic purpura

Response to splenectomy is durable after a certain point in time in adult patients with chronic immune thrombocytopenic purpura

Thrombocytopenic Purpura After Administration of Gold

Massive Postoperative Hemorrhage Due to Unrecognized Thrombocytopenia

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