2008
DOI: 10.1016/j.pbb.2008.01.004
|View full text |Cite
|
Sign up to set email alerts
|

The effect of corticotropin-releasing factor on prepulse inhibition is independent of serotonin in Brown Norway and Wistar-Kyoto rats

Abstract: Prepulse inhibition (PPI), a form of sensorimotor gating, is reduced in a number of psychiatric disorders. Two experiments were conducted to determine whether corticotropin-releasing factor (CRF), which decreases PPI, does so via effects on serotonin (5-HT). Wistar Kyoto (WKY) and Brown Norway (BN) rats were used in both experiments in order to examine whether straindependent differences would be apparent in response to manipulations of the CRF and 5-HT systems. In the first experiment, WKY and BN rats receive… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

2
17
0

Year Published

2009
2009
2012
2012

Publication Types

Select...
5

Relationship

3
2

Authors

Journals

citations
Cited by 7 publications
(19 citation statements)
references
References 77 publications
2
17
0
Order By: Relevance
“…The increase in startle amplitude in the WKY rats was not the cause of the CRF-induced decrease in percent PPI, as percent PPI was also significantly decreased in the WKY rats that did not show a CRF-induced increase in startle amplitude. Additionally, we have shown that ketanserin blocks the CRF-induced increase in startle amplitude in WKY rats without affecting the decrease in PPI [57]. The failure of the BN rats to show a CRF-induced increase in startle amplitude is unusual, but is in agreement with our previous results with this rat strain [33, 57].…”
Section: Discussionsupporting
confidence: 89%
See 3 more Smart Citations
“…The increase in startle amplitude in the WKY rats was not the cause of the CRF-induced decrease in percent PPI, as percent PPI was also significantly decreased in the WKY rats that did not show a CRF-induced increase in startle amplitude. Additionally, we have shown that ketanserin blocks the CRF-induced increase in startle amplitude in WKY rats without affecting the decrease in PPI [57]. The failure of the BN rats to show a CRF-induced increase in startle amplitude is unusual, but is in agreement with our previous results with this rat strain [33, 57].…”
Section: Discussionsupporting
confidence: 89%
“…Additionally, we have shown that ketanserin blocks the CRF-induced increase in startle amplitude in WKY rats without affecting the decrease in PPI [57]. The failure of the BN rats to show a CRF-induced increase in startle amplitude is unusual, but is in agreement with our previous results with this rat strain [33, 57]. This failure, as well as the relatively low levels of PPI seen in BN rats, suggests that the strain, in general, has relatively low startle plasticity.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…For instance, Bakshi et al (1994) found that ketanserin administration is not effective at reversing phencyclidine-induced PPI disruptions, but Varty and Higgins (1995) reported that it can overturn dizocilpine-induced PPI deficits. Also, it has been shown that ketanserin does not attenuate the corticotropin-releasing factor-induced PPI disruption (Sutherland et al 2008). Regarding the effects of serotonin antagonists tested against dopaminergic drugs, Geyer et al (1999) showed that the selective 5-HT 2 -receptor antagonist M100907 failed to reverse apomorphine-induced PPI deficits.…”
Section: Ketanserin Interactions With Amphetamine-induced Ppi Impairmmentioning
confidence: 99%