The Effect of COVID-19 on Gut Microbiota: Exploring the Complex Interplay and Implications for Human Health

Akter, Shamima; Tasnim, Sa’dia; Barua, Rashu; Choubey, Mayank; Arbee, Shahida; Mohib, Mohammad Mohabbulla; Minhaz, Naofel; Choudhury, Ajanta; Sarker, Pallab; Mohiuddin, Mohammad Sarif

doi:10.3390/gidisord5030028

Cited by 7 publications

(8 citation statements)

References 150 publications

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“…Dysbiosis is therefore linked to systemic immunological responses and immune dysfunction across the body. Restoring a balanced gut microbiota may have therapeutic promise for addressing immunological dysfunction and relieving long-term COVID-19 symptoms ( Akter et al., 2023 ). Long COVID-19 symptoms sometimes overlap with other health issues.…”

Section: Covid-19 and Long-term Effects On Gut Microbiota And Immunol...mentioning

confidence: 99%

COVID-19 influenced gut dysbiosis, post-acute sequelae, immune regulation, and therapeutic regimens

Raj,

Bruce,

Anbalagan

et al. 2024

Front. Cell. Infect. Microbiol.

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The novel coronavirus disease 2019 (COVID-19) pandemic outbreak caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has garnered unprecedented global attention. It caused over 2.47 million deaths through various syndromes such as acute respiratory distress, hypercoagulability, and multiple organ failure. The viral invasion proceeds through the ACE2 receptor, expressed in multiple cell types, and in some patients caused serious damage to tissues, organs, immune cells, and the microbes that colonize the gastrointestinal tract (GIT). Some patients who survived the SARS-CoV-2 infection have developed months of persistent long-COVID-19 symptoms or post-acute sequelae of COVID-19 (PASC). Diagnosis of these patients has revealed multiple biological effects, none of which are mutually exclusive. However, the severity of COVID-19 also depends on numerous comorbidities such as obesity, age, diabetes, and hypertension and care must be taken with respect to other multiple morbidities, such as host immunity. Gut microbiota in relation to SARS-CoV-2 immunopathology is considered to evolve COVID-19 progression via mechanisms of biochemical metabolism, exacerbation of inflammation, intestinal mucosal secretion, cytokine storm, and immunity regulation. Therefore, modulation of gut microbiome equilibrium through food supplements and probiotics remains a hot topic of current research and debate. In this review, we discuss the biological complications of the physio-pathological effects of COVID-19 infection, GIT immune response, and therapeutic pharmacological strategies. We also summarize the therapeutic targets of probiotics, their limitations, and the efficacy of preclinical and clinical drugs to effectively inhibit the spread of SARS-CoV-2.

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Section: Covid-19 and Long-term Effects On Gut Microbiota And Immunol...mentioning

confidence: 99%

COVID-19 influenced gut dysbiosis, post-acute sequelae, immune regulation, and therapeutic regimens

Raj,

Bruce,

Anbalagan

et al. 2024

Front. Cell. Infect. Microbiol.

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“…Research conducted on both humans and animals suggests that green and black catechin flavonoids can be quite effective in protecting against brain aging while reducing risk factors associated with dementia, AD or PD [56,57]. Beyond its well-known antioxidant capabilities research suggests that green teas catechins also contribute to neuron viability by influencing cell survival genes signal transduction pathways and mitochondrial function [58,59]. As such natural compounds like green tea present an exciting possibility as a cytoprotective therapy for neurodegenerative diseases.…”

Section: Effect Of Green Tea In Different Diseasesmentioning

confidence: 99%

The Potent Potential of Green Tea In against Cardiac Disorders: A Comprehensive Review of Recent Discoveries

Akter,

Choubey,

Arbee

et al. 2023

Preprint

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A preventive effect for tea and its bio active components in cardiovascular health has been suggested by the results of several epidemiological studies, treatments utilizing randomized controlled trials, and mechanistic investigations. Therefore, scientific interest in green tea's ability to prevent cardiovascular diseases (CVDs) is growing. Green tea benefits for the metabolic syndrome, which includes diabetes and hypertension but may also raise cholesterol levels. Additionally, green tea reduces the mortality from any cause, arrhythmia, stroke, coronary heart disease, heart failure, and other conditions.

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“…The severe form of COVID-19 usually appears one week after the first symptoms, and the clinical manifestations can become catastrophic. Observational studies emphasized the role of dysbiosis in acute and post-acute COVID-19 and its connection to the severity of the disease [15]. The COVID-19 pandemic placed a significant burden on worldwide healthcare through the economic challenges related to increasing medical healthcare costs and the incidence of medical-system-associated infections (nosocomial infections).…”

Section: Introductionmentioning

confidence: 99%

COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit

Stoian,

Andone,

Boeriu

et al. 2024

Antibiotics

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Since the emergence of SARS-CoV-2 in late 2019, the global mortality attributable to COVID-19 has reached 6,972,152 deaths according to the World Health Organization (WHO). The association between coinfection with Clostridioides difficile (CDI) and SARS-CoV-2 has limited data in the literature. This retrospective study, conducted at Mureș County Clinical Hospital in Romania, involved 3002 ICU patients. Following stringent inclusion and exclusion criteria, 63 patients were enrolled, with a division into two subgroups—SARS-CoV-2 + CDI patients and CDI patients. Throughout their hospitalization, the patients were closely monitored. Analysis revealed no significant correlation between comorbidities and invasive mechanical ventilation (IMV) or non-invasive mechanical ventilation (NIMV). However, statistically significant associations were noted between renal and hepatic comorbidties (p = 0.009), death and CDI-SARS-CoV-2 coinfection (p = 0.09), flourochinolone treatment and CDI-SARS-CoV-2 infection (p = 0.03), and an association between diabetes mellitus and SARS-CoV-2-CDI infection (p = 0.04), as well as the need for invasive mechanical ventilation (p = 0.04). The patients with CDI treatment were significantly younger and received immuno-modulator or corticotherapy treatment, which was a risk factor for opportunistic agents. Antibiotic and PPI (proton pump inhibitor) treatment were significant risk factors for CDI coinfection, as well as for death, with PPI treatment in combination with antibiotic treatment being a more significant risk factor.

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The Effect of COVID-19 on Gut Microbiota: Exploring the Complex Interplay and Implications for Human Health

Cited by 7 publications

References 150 publications

COVID-19 influenced gut dysbiosis, post-acute sequelae, immune regulation, and therapeutic regimens

COVID-19 influenced gut dysbiosis, post-acute sequelae, immune regulation, and therapeutic regimens

The Potent Potential of Green Tea In against Cardiac Disorders: A Comprehensive Review of Recent Discoveries

COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit

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