The effect of COVID-19 on burn management and outcomes in a resource-limited setting

Gallaher, Jared; Abid, Mustafa; Kayange, Linda; Purcell, Laura N.; Charles, Anthony

doi:10.1016/j.burns.2022.08.004

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…6 In this current COVID-19 pandemic, given the high incidence of burn injuries on a daily basis, it brings to our plastic surgeons' attention whether patients suffering from severe burn complicated with COVID-19 infection will lead to the aggravation of the traumatic condition of burn injuries as well as deteriorated COVID-19 outcomes. 7,8 The burn injury is recognised as an acute disease associated with many systemic disorders, including acute respiratory distress syndrome (ARDS) and blood coagulation, which happens to be major complications in COVID-19 patients requiring urgent and efficient treatment. 9,10 Recent studies have suggested alarmingly high admission and mortality rates in severe burn patients from the intensive care unit (ICU) during the pandemic of COVID-19.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, dysregulated immune activation and inflammatory response is commonly observed in patients with COVID‐19 6 . In this current COVID‐19 pandemic, given the high incidence of burn injuries on a daily basis, it brings to our plastic surgeons' attention whether patients suffering from severe burn complicated with COVID‐19 infection will lead to the aggravation of the traumatic condition of burn injuries as well as deteriorated COVID‐19 outcomes 7,8 …”

Section: Introductionmentioning

confidence: 99%

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Mining the potential therapeutic targets for COVID‐19 infection in patients with severe burn injuries via bioinformatics analysis

Cai

Deng

Shi

et al. 2023

International Wound Journal

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The Coronavirus Disease‐19 (COVID‐19) pandemic is posing a serious challenge to human health. Burn victims are susceptible to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection leading to delayed recovery and even profound debilitation. Nevertheless, the molecular mechanisms underlying COVID‐19 and severe burn are yet to be elucidated. In our work, the differentially expressed genes (DEGs) were identified from GSE157852 and GSE19743, and the common DEGs between COVID‐19 and severe burn were extracted. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), protein–protein interactions (PPI), gene coexpression network, and multifactor regulatory network analysis of hub genes were carried out. A total of 44 common DEGs were found between COVID‐19 and severe burn. Functional analyses indicated that the pathways of immune regulation and cytokine response participated collectively in the development of severe burn and progression of COVID‐19. Ten significant hub genes were identified, including MERTK, SIRPA, TLR3, ITGB1, DPP4, PTPRC, LY75, IFIT1, IL4R, and CD2. In addition, the gene coexpression network and regulatory network were constructed containing 42 microRNAs (miRNAs) and 2 transcription factors (TFs). Our study showed the shared pathogenic link between COVID‐19 and severe burn. The identified common genes and pivotal pathways pave a new road for future mechanistic researches in severe burn injuries complicated with COVID‐19.

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