The effect of creatine supplementation on myocardial function, mitochondrial respiration and susceptibility to ischaemia/reperfusion injury in sedentary and exercised rats

Webster, Ingrid; Toit, Eugene F. Du; Huisamen, Barbara; Lochner, Amanda

doi:10.1111/j.1748-1716.2012.02463.x

Cited by 10 publications

(14 citation statements)

References 97 publications

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“…In the study by Webster et al (2012), there was no positive effect to be seen on mitochondrial function by either exercise or creatine supplementation. The contrary would have been expected, because the available supply of phosphate groups to phosphorylate ADP limits energy availability during exercise.…”

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confidence: 78%

“…Legend has it that this was Winston Churchill's response to a reporter asking for his secret of longevity. As the article by Webster et al (2012) in this issue of Acta Physiologica (Oxford) shows, Churchill may again have been right! Using an exercise programme consisting of episodic swimming for 8 weeks, the authors of the highlighted article discovered that various parameters describing the recovery from myocardial infarction are worsened or unaffected by having exercised or having taken creatine supplements before the onset of infarction.…”

mentioning

confidence: 99%

“…Taken together, the manuscript by Webster et al (2012) should make us reconsider the effects of exercise and in particular creatine supplementation with regard to ischaemia/reperfusion of the heart. Keeping the limitations in mind, more trials may be required before we can rest at peace while exercising patients at risk for myocardial infarction.…”

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confidence: 99%

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Exercise and creatine supplementation attenuate recovery from myocardial ischaemia

Persson

2012

Acta Physiologica

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confidence: 78%

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confidence: 99%

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Exercise and creatine supplementation attenuate recovery from myocardial ischaemia

Persson

2012

Acta Physiologica

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“…Creatine (a-methyl-guanidinoacetic acid (Evangliou et al,2009) or N-aminoiminomethyl-Nmethylglycine (Alves et al,2013)) which was discovered in 1982 by chevereul (James et al,2002) is the most popular supplement used by athletes (Hoffman,2010;Gualano et al,2008;Ferrauti and Remmert,2010;Paula et al,2008;Rosene et al,2009;Cornelissen et al,2010;Webster et al,2012;Toylor et al,2011) especially following the summer olympic games in Barcelona-1992 (Rawson andClarkson,2000). Creatine (Cr) is an amino acid derivative produced by the liver, kidneys, and pancreas (Tortora and Derickson,2009;James et al,2002;Hoffman,2010;Andres et al,2014).…”

Section: Introductionmentioning

confidence: 99%

“…There are several types of supplementation including creatine monohydrate, Creatine pyrovate, creatine ethyl easter, tri‫ــ‬creatine citrate, and di‫ــ‬creatine citrate (Webster et al,2012;Hoffman,2010). Creatine monohydrate is commonly used by athletes due to monohydrate is already absorbed in the gut (Harris et al,2002).…”

Section: Introductionmentioning

confidence: 99%

Untitled

2014

JPES

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Abstract:This study examined the effect of short‫ــ‬term creatine monohydrate on time to volitional fatigue during running and blood parameters. Using a random, double‫ــ‬blind design, eleven male subjects (age 20.23±1.18 years, height 173.32±4.55 cm, weight 67.05±1.89 kg) participated in an incremental speed running test on treadmill following 5 days of creatine supplementation (CRE; 20 g/d followed by 5 g prior to trial) or control (CON trial). The subjects began the test with a standardized warm-up procedure of a 5‫ــ‬minute and 2 minutes stretching exercise for lower limbs. Each subject initially ran at 9 km/h on a treadmill. Every 2 minutes, the speed was increased by 1km/h until the point of volitional fatigue. Creatine kinase, blood lactate, and blood glucose were measured after each trial. The results showed that the time to volitional fatigue was significantly longer in CRE than that in CON (15.08±0.91min; 11.21±0.91min, respectively) (P < 0.05). Levels of creatine kinase, blood lactate and glucose were significantly higher in CRE compared to CON. This suggests that the ergogenic effect of creatine monohydrate following 5 days of supplementation have a positive impact on endurance exercise.

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Potential of creatine or phosphocreatine supplementation in cerebrovascular disease and in ischemic heart disease

et al. 2016

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Creatine is of paramount importance for maintaining and managing cellular ATP stores in both physiological and pathological states. Besides these "ergogenic" actions, it has a number of additional "pleiotropic" effects, e.g., antioxidant activity, neurotransmitter-like behavior, prevention of opening of mitochondrial permeability pore and others. Creatine supplementation has been proposed for a number of conditions, including neurodegenerative diseases. However, it is likely that creatine's largest therapeutic potential is in those diseases caused by energy shortage or by increased energy demand; for example, ischemic stroke and other cerebrovascular diseases. Surprisingly, despite a large preclinical body of evidence, little or no clinical research has been carried out in these fields. However, recent work showed that high-dose creatine supplementation causes an 8-9 % increase in cerebral creatine content, and that this is capable of improving, in humans, neuropsychological performances that are hampered by hypoxia. In addition, animal work suggests that creatine supplementation may be protective in stroke by increasing not only the neuronal but also the endothelial creatine content. Creatine should be administered before brain ischemia occurs, and thus should be given for prevention purposes to patients at high risk of stroke. In myocardial ischemia, phosphocreatine has been used clinically with positive results, e.g., showing prevention of arrhythmia and improvement in cardiac parameters. Nevertheless, large clinical trials are needed to confirm these results in the context of modern reperfusion interventions. So far, the most compelling evidence for creatine and/or phosphocreatine use in cardiology is as an addition to cardioplegic solutions, where positive effects have been repeatedly reported.

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The effect of creatine supplementation on myocardial function, mitochondrial respiration and susceptibility to ischaemia/reperfusion injury in sedentary and exercised rats

Cited by 10 publications

References 97 publications

Exercise and creatine supplementation attenuate recovery from myocardial ischaemia

Exercise and creatine supplementation attenuate recovery from myocardial ischaemia

Untitled

Potential of creatine or phosphocreatine supplementation in cerebrovascular disease and in ischemic heart disease

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