This paper analyses some effects of this directive on the agrochemical market and assumes new effects resulting from the introduction of the revision. Suggestions are made as to how pesticide risk assessment will have to adapt to answer the request of legislators on safety standards and sustainability, introducing probabilistic PRA. Toxicity and exposure functions will be fully characterised, producing distributions of predicted impact and quantifying the variability and uncertainty. For adopting PRA studies at the local/catchment scale, new assessment schemes will be necessary.