The Effect of Cross-Linked Hyaluronic Acid in Surgical Extraction of Impacted Mandibular Third Molars

Bayoum, A; Nadershah, Mohammed; Albandar, Abdulhadi Mohammed; Alsulaimani, B; Sankour, I; Gadi, L; O, Osama; Tayeb, Rabab A.; Quqandi, R; Dabroom, W; Merdad, Yasser

doi:10.16966/2378-7090.254

Cited by 3 publications

(4 citation statements)

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“…Prior studies on third molar surgery include Koray et al [1], Gocmen et al [49], Gokhan et al [41], and Bayoum et al [37]. The 2014 study of Koray et al [1] evaluated the efficacy of HA compared to benzydamine hydrochloride to control pain, swelling, and limited mouth opening after third molar intervention.…”

Section: Discussionmentioning

confidence: 99%

“…In 2018, Bayoum et al [37] studied the use of cross-linked HA following intervention for impacted mandibular third molar. The approach reduced postoperative swelling, pain, and limited mouth opening.…”

Section: Discussionmentioning

confidence: 99%

“…HA can be used as a drug delivery material by various routes of administration. Tables 1 and 2 provide the results of a literature survey of English articles of randomized controlled clinical trials published from 2014 to 2018 describing the applications of HA in dentistry and oral and maxillofacial surgery [1363738394041].…”

Section: Ha Mutagenicitymentioning

confidence: 99%

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Generation of novel hyaluronic acid biomaterials for study of pain in third molar intervention: a review

Shuborna

Chaiyasamut

Sakdajeyont

et al. 2019

J Dent Anesth Pain Med

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Hyaluronic acid (HA) has long been studied in diverse applications. It is a naturally occurring linear polysaccharide in a family of unbranched glycosaminoglycans, which consists of repeating di-saccharide units of N-acetyl-D-glucosamine and D-glucuronic acid. It is almost ubiquitous in humans and other vertebrates, where it participates in many key processes, including cell signaling, tissue regeneration, wound healing, morphogenesis, matrix organization, and pathobiology. HA is biocompatible, biodegradable, muco-adhesive, hygroscopic, and viscoelastic. These unique physico-chemical properties have been exploited for several medicinal purposes, including recent uses in the adjuvant treatment for chronic inflammatory disease and to reduce pain and accelerate healing after third molar intervention. This review focuses on the post-operative effect of HA after third molar intervention along with its various physio-chemical, biochemical, and pharmaco-therapeutic uses.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Generation of novel hyaluronic acid biomaterials for study of pain in third molar intervention: a review

Shuborna

Chaiyasamut

Sakdajeyont

et al. 2019

J Dent Anesth Pain Med

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“…The Cross-linked HA with the Gel foam group demonstrated a statistically significant reduction in pain, swelling, and trismus on day seven compared to the control group (p<0.05). 44 In a pilot split mouth study conducted in 10 patients by Mostafa D, it was reported that HA enhances the socket healing and can be used as supportive treatment to improve the wound healing. 46 The above studies suggest that HA can effectively reduce pain & inflammation and may hasten the healing process in extraction socket.…”

Section: Clinical Evidence On the Role Of Ha In Post-extraction Healingmentioning

confidence: 99%

Role of hyaluronic acid in post-extraction healing

Shukla,

Pebilli

2023

JOOO

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In dental practice, rapid healing of post-extraction wounds is integral in reducing the risk of infection that causes patient discomfort. Wound healing is a dynamic process requiring adequate vascularization and collagen matrix deposition. The renewal of vessels determines traction that stimulates remodelling of the extracellular matrix, potentiating neo-vessel responses. The presence of topical agents may aid the regenerative and repair mechanisms & improve the healing process of damaged tissues. Commercial preparations based on low molecular weight hyaluronic acid (HA) have shown to improve the healing of connective tissue, epithelium, and mucosa. HA is used during the healing process as it primarily creates a temporary structure for depositing extracellular matrix (ECM) proteins, initiates cell adhesion, proliferation, and migration, and regulates vascular endothelial cell function. The present review article discusses the possible complications of delayed post-extraction healing and the role of hyaluronic acid in post-extraction wound healing and alveolar osteitis.

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Hyaluronic acid in tooth extraction: a systematic review and meta-analysis of preclinical and clinical trials

Domic,

Bertl,

Lang

et al. 2023

Clin Oral Invest

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Objectives To assess whether in animals or patients with ≥ 1 tooth extracted, hyaluronic acid (HyA) application results in superior healing and/or improved complication management compared to any other treatment or no treatment. Materials and methods Three databases were searched until April 2022. The most relevant eligibility criteria were (1) local application of HyA as adjunct to tooth extraction or as treatment of alveolar osteitis, and (2) reporting of clinical, radiographic, histological, or patient-reported data. New bone formation and/or quality were considered main outcome parameters in preclinical studies, while pain, swelling, and trismus were defined as main outcome parameters in clinical studies. Results Five preclinical and 22 clinical studies (1062 patients at final evaluation) were included. In preclinical trials, HyA was applied into the extraction socket. Although a positive effect of HyA was seen in all individual studies on bone formation, this effect was not confirmed by meta-analysis. In clinical studies, HyA was applied into the extraction socket or used as spray or mouthwash. HyA application after non-surgical extraction of normally erupted teeth may have a positive effect on soft tissue healing. Based on meta-analyses, HyA application after surgical removal of lower third molars (LM3) resulted in significant reduction in pain perception 7 days postoperatively compared to either no additional wound manipulation or the application of a placebo/carrier. Early post-operative pain, trismus, and extent of swelling were unaffected. Conclusions HyA application may have a positive effect in pain reduction after LM3 removal, but not after extraction of normally erupted teeth. Clinical relevance HyA application may have a positive effect in pain reduction after surgical LM3 removal, but it does not seem to have any impact on other complications or after extraction of normally erupted teeth. Furthermore, it seems not to reduce post-extraction alveolar ridge modeling, even though preclinical studies show enhanced bone formation.

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The Effect of Cross-Linked Hyaluronic Acid in Surgical Extraction of Impacted Mandibular Third Molars

Cited by 3 publications

References 0 publications

Generation of novel hyaluronic acid biomaterials for study of pain in third molar intervention: a review

Generation of novel hyaluronic acid biomaterials for study of pain in third molar intervention: a review

Role of hyaluronic acid in post-extraction healing

Hyaluronic acid in tooth extraction: a systematic review and meta-analysis of preclinical and clinical trials

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