The Effect of Crude Diosgenin Extract from Purple and Yellow Greater Yams (Dioscorea alata L.) on the Lipid Profile of Dyslipidemia Rats

Harijono, Harijono; Estiasih, Teti; Ariestiningsih, Ayuningtyas Dian; Wardani, Nela Agustin Kusuma

doi:10.9755/ejfa.2016-01-086

Cited by 8 publications

(5 citation statements)

References 18 publications

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“…Concerning other relevant biological activities, according to several in vitro and in vivo studies, this phytosteroid possesses protective benefits against metabolic diseases such as diabetes and obesity [16, 19, 59, 60], metabolic syndrome [61], and dyslipidemias, including hypercholesterolemia [7, 21, 62, 63]…”

Section: Pharmacology: Recent Datamentioning

confidence: 99%

Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology

Jesus

Martins

Gallardo

et al. 2016

Journal of Analytical Methods in Chemistry

210

125

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Diosgenin, a steroidal sapogenin, occurs abundantly in plants such as Dioscorea alata, Smilax China, and Trigonella foenum graecum. This bioactive phytochemical not only is used as an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry, but has revealed also high potential and interest in the treatment of various types of disorders such as cancer, hypercholesterolemia, inflammation, and several types of infections. Due to its pharmacological and industrial importance, several extraction and analytical procedures have been developed and applied over the years to isolate, detect, and quantify diosgenin, not only in its natural sources and pharmaceutical compositions, but also in animal matrices for pharmacodynamic, pharmacokinetic, and toxicological studies. Within these, HPLC technique coupled to different detectors is the most commonly analytical procedure described for this compound. However, other alternative methods were also published. Thus, the present review aims to provide collective information on the most recent pharmacological data on diosgenin and on the most relevant analytical techniques used to isolate, detect, and quantify this compound as well.

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Section: Pharmacology: Recent Datamentioning

confidence: 99%

Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology

Jesus

Martins

Gallardo

et al. 2016

Journal of Analytical Methods in Chemistry

210

125

View full text Add to dashboard Cite

show abstract

“…Purple yam (Dioscorea alata L.), is widely planted in tropical and subtropical regions, and is used as a medicinal and edible plant [8,9]. Previous research has mainly focused on its nutritional and functional properties [10,11], and there are few reports on purple yam RS. The content of starch in purple yam is approximately 16-20% of the total biomass, and the starch contains a high level of amylose [12], which may contribute to the formation of RS.…”

Section: Introductionmentioning

confidence: 99%

Comparison of structural features and in vitro digestibility of purple yam (Dioscorea alata L.) resistant starches by autoclaving and multi-enzyme hydrolysis

Teng

et al. 2017

Food Sci Biotechnol

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Resistant starches (RS) were prepared from purple yam by dual autoclaving-retrogradation (DAS), and pullulanase debranching treatment (PDS). DAS and PDS were then hydrolyzed by α-amylase and amyloglucosidase to obtain DAS.H and PDS.H. Differences in structural characteristics and in vitro digestibility among the four samples were investigated. The results showed that granules of RS had a rough surface and irregular shape. DAS had the lowest amylose content (29.52%), whereas PDS.H had the highest amylose content (41.96%). The order of crystallinity of the RS was: PDS.H (31.23%) > DAS.H (30.16%) > PDS (21.23%) > DAS (15.30%). Analysis by in vitro digestibility indicated a decreased hydrolysis index and glycemic index due to lower swelling power and water-binding capacity, and a well-ordered double helix structure and more crystallization in PDS.H than in the other RS samples. These results suggest that pullulanase debranching combined with α-amylase and amyloglucosidase hydrolysis may produce better RS with improved crystalline structure and higher digestion resistibility.

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“…Diosgenin inhibits the cholesterol synthesis through the inhibition of HMG-CoA reductase (Shanthakumari et al, 2008;Imanningsih et al, 2014;Son et al, 2007). Therefore, both crude extracts of diosgenin from D. alata have been reported to enhance fecal cholesterol secretion and improvement in blood lipid profiles Harijono et al, 2016).…”

Section: Hyperlipidemic Activitymentioning

confidence: 99%

Current Highlights on Biochemical and Pharmacological Profile of Dioscorea Alata : A Review

Kaur¹,

Khatun²,

Suttee³

2021

PLANT ARCHIVES

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Dioscorea alata, also known as water yam is an important plant found globally. Nearly 600 different yam species have been reported around the world. D. alata is an edible product, it is highly cultivated in countries like tropical South America, Africa, Australia, and South-eastern U.S. Dioscorea alata, commonly known as water yam, purple yam, ube, or greater yam has been reported to have diverse activities in various diseases. D. alata belongs to dioscoreaceae family and has been found to have antioxidant and anti-inflammatory, anti-apoptotic properties. The metabolic products of dioscorea alata are phenolic compounds, reducing sugars, flavonoids, glycoside, saponins, alkaloids, anthraquinones, proteins, tannins etc. The active constituents of D. alata are diosgenin, dioscorine, dioscin, cholin, mucin, allantoin, crude fat, crude fiber, catechins, chlorogenic acids, proanthocyanidins, myricetin, diosbulbin and sapogenin. Diosgenin is one of the main steroidal glycoside has been reported to have different activities like anti-diabetic activity, anti-hypertensive activity, anti-cancer activity, anti-inflammatory activity and cardio protective activity. Diosgenin is effective in heart disease due to the anti-oxidative and anti-apoptotic activity. Diosgenin has also been found to reduce oxidative stress and increase the levels of glutathione, SOD and catalase activity. Diosgenin also reported to inhibit the apoptosis by reducing the activation of caspase 9, a pro-apoptotic factor. Furthermore, bioactive compounds, including diosgenin, anthocyanins and dietary fiber of D. alata tuber has potential to prevent the condition of hyperlipidemia by normalizing blood lipid profiles. However, further investigations are required to find the effect of D. alata on cardiovascular disorders.

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The Effect of Crude Diosgenin Extract from Purple and Yellow Greater Yams (Dioscorea alata L.) on the Lipid Profile of Dyslipidemia Rats

Cited by 8 publications

References 18 publications

Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology

Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology

Comparison of structural features and in vitro digestibility of purple yam (Dioscorea alata L.) resistant starches by autoclaving and multi-enzyme hydrolysis

Current Highlights on Biochemical and Pharmacological Profile of Dioscorea Alata : A Review

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