The effect of cumin (<i>Cuminum cyminum</i> L.) supplementation on glycemic indices: A systematic review and meta‐analysis of randomized controlled trials

Karimian, Jahangir; Farrokhzad, Amirhosein; Jalili, Cyrus

doi:10.1002/ptr.7075

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…Cumin administration significantly decreased FBG and HbA 1c values, [114][115][116] compared with controls, but its effects were inconsistent. It had no significant effects on fasting SI or HOMA-IR (Table 2).…”

Section: Cumin (Cuminum Cyminum L)mentioning

confidence: 89%

“…115 Diverse baseline characteristics of subjects were noted to contribute to significant heterogeneity in FBG outcomes. For example, from one subgroup analysis, 114 there was no effect of cumin on FBG levels when considering the total population of subjects, whereas a substantial decrease of −32.58 mg/dL was evident for those given cumin and exhibiting BMI values ≤30 kg/m 2 .…”

Section: Cumin (Cuminum Cyminum L)mentioning

confidence: 99%

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Potential Benefit of Spices for Glycemic Control

Singletary

2024

Nutr Today

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The prevalence of hyperglycemia is increasing worldwide in large part due to the escalating prevalence of obesity. It can occur along with other disorders and diseases, contributing to escalating health costs and accumulating disabilities. Besides dietary approaches and availability of antidiabetic medications, other complementary approaches and adjunct therapies using biologically active botanical phytochemicals have received growing attention for managing type 2 diabetes mellitus. Spices are one source of these bioactive plant constituents, and considerable preclinical studies have investigated their possible health benefits. There also are an increasing number of human clinical trials assessing the ability of spices and their individual plant constituents to improve glucose homeostasis in those with type 2 diabetes mellitus and other dysglycemic conditions. This narrative review provides a summary of the human studies evaluating the effects of select spices on glucose homeostasis and highlights areas for future research.

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Section: Cumin (Cuminum Cyminum L)mentioning

confidence: 89%

Section: Cumin (Cuminum Cyminum L)mentioning

confidence: 99%

Potential Benefit of Spices for Glycemic Control

Singletary

2024

Nutr Today

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“…The presence of these compounds can inhibit alpha-glucosidase and aldose reductase, resulting in decreased reactive oxygen species (ROS) production and glucose uptake [25][26][27][28][29][30][31][32][33][34][35]. Furthermore, CC can stimulate insulin secretion by increasing calcium influx and influencing nesfatin-1 [36]. In addition, other bioactive components found in CC serve to maintain the integrity of pancreatic β-cells, thereby improving the secretion of insulin and reducing insulin resistance in hepatocytes [20].…”

Section: Discussionmentioning

confidence: 99%

Anti-diabetic effect of a combination of black seed (Nigella sativa) and cumin (Cuminum cyminum), a two-step study from bench to bed

Ghods,

Karimi,

Salari

et al. 2024

FFS

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Background: Type 2 Diabetes mellitus (T2DM) is a prevalent chronic condition causing one-fifth million deaths globally. Standard treatments for diabetes are not sufficiently effective, highlighting the need to find adjunctive treatments to improve glycemic control. Nigella sativa (NS) and Cuminum cyminum (CC) are two herbal medicines known for their antioxidant, anti-inflammatory, and antidiabetic properties. Objective: This study aims to assess the impact of supplementation with a combination of NS and CC on glycemic regulation among individuals with T2DM. The research was conducted in two phases, pre-clinical and clinical. Methods: In the in-vivo phase, thirty-two male mice were allocated into four groups, each comprising eight mice. These groups were categorized as follows: control, diabetic-type 2, diabetic-intervention-NS, and diabetic-intervention-NS+CC. Following the induction of diabetes using Streptozotocin, the mice in NS and NS-CC groups received 400 mg/kg/d or 360 mg/kg/d NS oil plus 40 mg/kg/d CC oil respectively for 30 days. An insulin tolerance test (ITT), an intraperitoneal glucose tolerance test (IPGTT), and blood glucose were conducted subsequently. In the clinical study, eighty patients who have been clinically diagnosed with type 2 diabetes were randomly assigned to two distinct groups to receive a daily dosage of 2000 mg NS-CC soft gel or sunflower oil soft gel for 12 weeks. The examination of fasting blood glucose (FBG) and hemoglobin A1C (HbA1C) was performed both before and after the completion of the intervention. Results: Preclinical findings exhibited a notable decrease in glucose levels in NS (decrease from 271.1±21.71 to 167.6±8.14 mg/dl) and NS-CC (decrease from 275.4±25.57 to 136±13.07 mg/dl). Also, ITT and IPGTT levels showed significantly more reduction in NS and NS-CC compared to the non-treated diabetic group. Treating with NS-CC, but not NS alone decreased ITT to a normal level with no significant difference with the non-diabetic group. In phase 2, supplementation with NS-CC led to a significantly greater reduction of the mean of fasting blood sugar (FBS) (P=0.001) concentration and HbA1C (P<0.001) compared to placebo. Conclusions: NS-CC oil may reduce insulin resistance and blood glucose levels in murine models and individuals with T2DM. Keywords: Nigella sativa, Cuminum cyminum, Type 2 diabetes mellitus, Glycemic control, Diabetic mice

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“…Cumin has been reported for several medicinal applications, mainly for dispelling colds, inhibiting blood platelet aggregation, antibacterial properties, and enhancing appetite. [4][5][6][7] Due to its aromatic nature, cumin as a food additive and avoring agent is extensively utilized in food preparations, including meats, cheeses, soups, breads, pickles, and liqueurs. Today, cumin is the second most popular spice in the world aer black pepper.…”

Section: Introductionmentioning

confidence: 99%