The Effect of Curcuma Xanthorrhiza Ethanol Extract on the Viability of Streptococcus Mutans and Aggregatibacter Actinomycetemcomitans (Dental  Biofilm Research: In Vitro Study)

Diana, Royan; Joenoes, Hediyanti; Djais, Ariadna Adisattya

doi:10.22159/ajpcr.2017.v10s5.23087

Cited by 3 publications

(4 citation statements)

References 13 publications

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“…To evaluate this notion, we tested dual species biofilm models (combination Gram-positive and Gram-negative bacteria) treated with C. xanthorrhiza ethanol extract, then measured the minimum of biofilm eradication (MBEC) using MTT-assay to assess the viability cell (Table 1). Our study demonstrated that C. xanthorrhiza ethanol extract was better eradicating dual-species biofilm (for example, S. sanguinis with Porphyromonas gingivalis; or S. mutans with A. actinomycetemcomitans), whereas not effective against single-species P. gingivalis biofilm nor single-species A. actinomycetemcomitans [46,51]. This result may be possible due to the antagonist interaction between S. sanguinis and P. gingivalis that causes an incomplete formation of the EPS matrix surrounding the biofilm.…”

Section: Antibiofilmmentioning

confidence: 75%

“…Medicinal plant's extract from Acacia arabica, Tamarix aphylla L., and Melia azadirachta L. showed evidence of reducing oral biofilm formation and cleaning the well-developed oral biofilm [45]. Medicinal plant from South East Asia, C. xanthorrhiza Roxb., has also been proven through several studies to have eradication and inhibition effects against oral bacteria and candida biofilm [23,[46][47][48][49][50][51][52][53].…”

Section: Current Treatment and Challenges Using Chx And Other Antibac...mentioning

confidence: 99%

“…Consistent with that, our study also demonstrated that the antibiofilm activity of C. xanthorrhiza ethanol extract is more effective in the early phase of biofilm formation. These indicate that the EPS matrix of mature biofilm implicates the resistance [46,50,51]. Although high concentration of XNT (1000 μg/mL) reportedly completely killed the biofilm, toxicity should be a major concern.…”

Section: Antibiofilmmentioning

confidence: 99%

“…and 24 hr. only reduce 50% and 20% bacteria viability, respectively [51] Table 1. Effect of C. xanthorrhiza ethanol extract against single and dual species biofilm.…”

Section: S Mutans-a Actinomycetemcomitansmentioning

confidence: 99%

See 3 more Smart Citations

Curcuma Xanthorrhiza Roxb. An Indonesia Native Medicinal Plant with Potential Antioral Biofilm Effect

Suniarti¹,

Puspitawati²,

Yanuar³

et al. 2022

Focus on Bacterial Biofilms

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Most common oral diseases are directly related to oral biofilm, a complex community of microorganisms inhibiting the oral cavity. Recent studies provide deeper knowledge on how free-floating bacteria form a structurally organized microecosystem and on its pathogenicity and its self-defense mechanisms; thus, creating an understanding of the challenges in eliminating oral biofilm and maintaining the balance of oral ecosystem. Chlorhexidine has been the standard oral antimicrobial agent for decades. However, studies showed that it is less effective against bacteria in the form of biofilm that leads to an ongoing search of another method to fight against biofilm, including the use of plant-derived compounds. Medicinal plants are known to contain secondary metabolites, which are not only important in protecting the plant from any harmful environment but also potential as antimicroorganism and antioral biofilm for humans. Curcuma xanthorrhiza Roxb., containing xanthorrhizol (XNT), an essential bioactive compound, is an Indonesian native medicinal plant proven to have antibacterial and antibiofilm activities by several in vitro studies. The understanding of biofilm formation, its resistance to common drugs, and the potential role of C. xanthorrhiza-derived compounds as antibacterial and antibiofilm may contribute to developing C. xanthorrhiza into the alternative weapon against oral biofilm-related diseases.

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Section: Antibiofilmmentioning

confidence: 75%

Section: Current Treatment and Challenges Using Chx And Other Antibac...mentioning

confidence: 99%

Section: Antibiofilmmentioning

confidence: 99%

“…and 24 hr. only reduce 50% and 20% bacteria viability, respectively [51] Table 1. Effect of C. xanthorrhiza ethanol extract against single and dual species biofilm.…”

Section: S Mutans-a Actinomycetemcomitansmentioning

confidence: 99%

See 2 more Smart Citations

Curcuma Xanthorrhiza Roxb. An Indonesia Native Medicinal Plant with Potential Antioral Biofilm Effect

Suniarti¹,

Puspitawati²,

Yanuar³

et al. 2022

Focus on Bacterial Biofilms

View full text Add to dashboard Cite

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Rheological properties of the mixture of Lentinan and saliva and its inhibitory effect on Streptococcus mutans

Wang

et al. 2023

International Journal of Food Properties

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Bioanalytical of Uplc Method Development and Validation of Xanthorrizol and Its Application to Pharmacokinetic Study

NOVIZA,

JULIANTO,

ABDUL MAJEED

et al. 2024

Int J App Pharm

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Objective: A simple, straightforward, ultra-performance liquid chromatography (UPLC) with a fluorescence detector method was developed and validated to determine xanthorrhizol in rat plasma. This method was successfully applied to an oral pharmacokinetic study. Methods: Xanthorrhizol was separated using a C18 column in an isocratic mode using a mobile phase of acetonitrile: water (85:15 v/v) at a 0.4 ml/min flow rate. The fluorescence detector was set at 230 nm excitation and 320 nm emission wavelengths. The method was then applied in the pharmacokinetic study involving 12 Sprague-Dawley rats. Results: The developed bioanalytical methods were found to be linear in the range of 0.078–5 mg/ml with a correlation coefficient of r2=0.999. The percentage recovery of xanthorrhizol was more than 95%, and the relative standard deviation was less than 2. These results indicate that the method is accurate and precise. The limit of detection (LOD) and limit of quantification (LOQ) of the technique were 0.123 µg/ml and 0.373 µg/ml, respectively. Furthermore, the stability studies demonstrated that xanthorrhizol is stable under various analytical conditions. The pharmacokinetic study revealed that the area under the curve (AUC) was 27.23±19.65 (µg. h/ml), the half-life (t 1/2) was 7.71±2.89 h, the mean residence time (MRT) was 13.86±4.06 h while the maximum concentration (Cmax) was 1.58±0.62 µg/ml, and the time to reach the maximum concentration (Tmax) was 1.33±0.20 h. Conclusion: The developed bioanalytical method was reliable and successfully met all validation criteria, making it a robust choice for quantifying xanthorrhizol. Therefore, it may be effectively utilized to determine xanthorrhizol in rat plasma following a pharmacokinetic study.

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The Effect of Curcuma Xanthorrhiza Ethanol Extract on the Viability of Streptococcus Mutans and Aggregatibacter Actinomycetemcomitans (Dental Biofilm Research: In Vitro Study)

Cited by 3 publications

References 13 publications

Curcuma Xanthorrhiza Roxb. An Indonesia Native Medicinal Plant with Potential Antioral Biofilm Effect

Curcuma Xanthorrhiza Roxb. An Indonesia Native Medicinal Plant with Potential Antioral Biofilm Effect

Rheological properties of the mixture of Lentinan and saliva and its inhibitory effect on Streptococcus mutans

Bioanalytical of Uplc Method Development and Validation of Xanthorrizol and Its Application to Pharmacokinetic Study

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