The Effect of Curcuma Zedoaria (Berg.) Roscoe Extract on Liver Function Tests of Rattus norvergicus Exposure by Cigarette Smoke

Abstract

Curcuma zedoaria (Berg.) Roscoe has been widely used traditionally as a valuable medicinal plant to treat many diseases due to its activity on repairing cell damage. This study aimed to evaluate the effect of ethanol extract of Curcuma zedoaria (CZE) on liver function test levels in male Winstar rats exposed by cigarette smoke. A total of 30 male rats were divided into six groups (n=5), i.e., control group(G1); negative control(G2); positive control(G3); cigarette smoke-exposure followed by administration of CZE 350 mg/kg b.wt group(G4), cigarette smoke-exposure followed by administration of CZE 525 mg/kg b.wt group(G5), and administration of CZE 525 mg/kg b.wt group (G6). Treatments were given for 45 days before blood collection and MDA measurements on rat liver tissue. The results showed that administration of 350 mg/kg b.wt., and 525 mg/kg b.wt reduced total protein, ALT, AST and ALP levels on rat exposed by cigarette smoke as well as decreased liver peroxidase level based on the average profile of MDA on rat liver tissue. In conclusion, administration of CZE showed the hepatoprotective effect on rats exposed by cigarette smoke.