2022
DOI: 10.2174/1871526522666220404083220
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The Effect of Curcumin on the Expression of INFγ, TNF-α, and iNOS Genes in PBMCs Infected with Leishmania major [MRHO/IR/75/ER]

Abstract: Background: Leishmaniasis, caused by Leishmania parasite, is one of the most important tropical neglected diseases. The urgent search for effective, inexpensive, and preferably herbal anti-leishmanial agents, is needed. Objective: Curcumin is a natural polyphenolic compound derived from turmeric that is well known for its antioxidant, anti-inflammatory, anti-tumor, and anti-cancer activity. Methods: The present work evaluates the anti-leishmanial [Leishmania major] activity of curcumin. The infected PBMCs … Show more

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Cited by 4 publications
(2 citation statements)
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“…Consistent with these findings, we observed upregulation of TNFα gene expression in endothelial cells after inflammatory treatment. Notably, endothelial cells and PBMCs can express TNFα [28, 29]. According to the PCA of qPCR results, the TNFα gene expression primarily occurs in LPS-activated PBMCs.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Consistent with these findings, we observed upregulation of TNFα gene expression in endothelial cells after inflammatory treatment. Notably, endothelial cells and PBMCs can express TNFα [28, 29]. According to the PCA of qPCR results, the TNFα gene expression primarily occurs in LPS-activated PBMCs.…”
Section: Discussionmentioning
confidence: 99%
“…Consistent with these findings, we observed upregulation of TNFα gene expression in endothelial cells which could have led to CD31/PECAM-1 inhibition and loss of cell-cell adhesions. Notably, that both endothelial cells and PBMCs could express TNFα [40, 41]. In the used setup, the cells were lyzed for RNA isolation directly from the microfluidic system, without separation of endothelial cells from potentially attached PBMCs in interest of time to process samples for RNA isolation.…”
Section: Discussionmentioning
confidence: 99%