The Effect of Cyproheptadine Hydrochloride (Periactin) and Megestrol Acetate (Megace) on Weight in Children With Cancer/Treatment-related Cachexia

Couluris, Marisa; Mayer, Johannes; Freyer, David R.; Sandler, Eric; Xu, Ping; Krischer, Jeffrey P.

doi:10.1097/mph.0b013e3181864a5e

Cited by 87 publications

(107 citation statements)

References 43 publications

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“…Its action as appetite stimulant appears not to be due to a hypoglycaemic-induced hyperphagia or an increase in endogenous growth hormones (Bergen, 1964;Stiel et al, 1970). Cyproheptadine is broadly used in human patients, including children, that suffer from diseases such as cancer, HIV, cystic fibrosis and eating disorders (see Chinuck et al, 2007;Couluris et al, 2008;Mahachoklertwattana et al, 2009), where an increase in body mass is desirable. Cyproheptadine is also used as an antihistaminic because it blocks H 1 histamine receptors (Stone et al, 1961) and, similar to other antihistaminic substances, cyproheptadine has minimal side effects, consisting mainly of transient drowsiness [see Homnick et al (Homnick et al, 2004) and references therein].…”

Section: The Use Of Cyproheptadine To Increase Begging Behaviourmentioning

confidence: 99%

“…This pharmaceutical is a type 2 serotonin receptor antagonist, which directly acts on the hunger centre at the hypothalamus (Stone et al, 1961;Chakrabarty et al, 1967). Cyproheptadine is broadly used in humans, including children, as a safe and effective appetite stimulant (Chinuck et al, 2007;Couluris et al, 2008;Mahachoklertwattana et al, 2009). It is also often used in other animals, mainly in cats (see e.g.…”

Section: Introductionmentioning

confidence: 99%

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Benefits associated with escalated begging behaviour of black-billed magpie nestlings overcompensate the associated energetic costs

Martín‐Gálvez

Pérez‐Contreras

Soler

et al. 2011

Journal of Experimental Biology

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SUMMARYSeveral experimental results support the existence of costs associated with exaggerated begging behaviour, which are assumed by some theoretical models of honest signalling in parent-offspring communication. However, to understand how honest begging behaviour is evolutionarily maintained in nature, the long-term cost-benefit output associated with exaggerated signals should also be estimated. As far as we know, the net cost-benefit balance of begging display has not previously been explored. Here, we used an appetite stimulant, cyproheptadine hydrochloride, to increase the feeling of hunger in some magpie nestlings. Supporting the use of cyproheptadine to manipulate hunger level and thereby begging behaviour, we found that experimental nestlings increased the frequency of begging and received more food than their control nestmates. Contrary to the expectation that physiological costs per se counteract the associated benefits of escalated begging signals, we found that near-fledging experimental magpies showed a better physical condition than control nestlings. These findings stress the interesting question of why magpie nestlings do not show to adults an escalated level of hunger if it implies an advantage. We discuss the responsibility of inclusive fitness costs and indirect genetic effects for the maintenance of honesty in parent-offspring communication.

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Section: The Use Of Cyproheptadine To Increase Begging Behaviourmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Benefits associated with escalated begging behaviour of black-billed magpie nestlings overcompensate the associated energetic costs

Martín‐Gálvez

Pérez‐Contreras

Soler

et al. 2011

Journal of Experimental Biology

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“…Marisa Couluris, D.O. et al [15] conducted a clinical study to test the efficacy of cyproheptadine in children suffering with concern associated cachexia to prevent further weight loss. The study was conducted for four weeks on 66 patients.…”

Section: Section: Paediatricsmentioning

confidence: 99%

Safety and Efficacy of a Combination of Cyproheptadine and Tricholine Citrate: Phase IV Study

Kiran¹,

Sheikh²,

Pawaskar³

2018

AIMDR

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Background: Undernutrition or anorexia is very common in infants and children in developing countries like India. An FDC of Cyproheptadine and Tricholine Citrate, an appetite and growth stimulant is popular in the treatment of undernutrition or anorexia. The phase IV clinical study was conducted for evaluating the efficacy and safety of combination of Cyproheptadine and Tricholine Citrate in the treatment of undernutrition or anorexia in infants and children. Methods: Out of 322 patients, 279 patients completed the study. Safety assessment was made by inspecting the adverse events during trial. Efficacy assessment was made by analysis the increase in appetite and meal frequency. Safety assessment was made by analysing the adverse events during the clinical trial. Result: Average increase in meal frequency and change in meal quantity (very low/low/moderate/high/very high) was analysed at all three visit. As compared to baseline visit, it was found that in conclusion visit the patients with very low and low appetite shifted to moderate and high appetite and some patients were found with very high appetite. The average meal frequency as compared to baseline visit was found out to be increased in conclusion visit. Conclusion: The combination of Cyproheptadine and Tricholine Citrate is safe and effective for the treatment of undernutrition or anorexia in infants and children.

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“…Aside from its antihistamine effects, cyprohepatine is also an appetite stimulant (12,13). To our knowledge, no previous clinical study has compared the efficacy of firstand second-generation oral HI-anti-histamines for treating children with perennial allergic rhinitis.…”

mentioning

confidence: 99%

A Comparative Study of Loratadine Syrup and Cyproheptadine HCL Solution for Treating Perennial Allergic Rhinitis in Taiwanese Children Aged 2–12 Years

Wang

et al. 2012

Int J Immunopathol Pharmacol

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We assessed the efficacy of loratadine syrup compared with cyproheptadine HCl solution for treating children aged from 2 to 12 years with perennial allergic rhinitis (PAR) in Taiwan. Sixty children with mite-induced PAR were enrolled and randomly placed into two treatment groups: loratadine syrup or cyproheptadine HCl solution. Treatment efficacy and symptom changes from baseline to post-treatment were evaluated by total symptom scores and visual analogue scales (VAS) during a 2-week period. There were no differences in age, gender, height, or weight between the two groups. After 2 weeks of treatment, there was a significantly greater reduction in symptom scores in the loratadine group than in the cyproheptadine group ( p<0.001). Clinical and subjective VAS showed significant differences in percentage changes from baseline between the loratadine and cyproheptadine groups at all time points (all p<0.001, in favor of loratadine). Clinical VAS change at week 1: 95.1 vs 11.3; subjective VAS change at week 1: 88.6 vs 13.6; clinical VAS change at week 2: 125.5 vs 18.3; subjective VAS change at week 2: 101.4 vs 7.1. Thus, loratadine was superior to cyproheptadine for alleviating both nasal and non-nasal symptoms of perennial allergic rhinitis in Taiwanese children aged 2–12 years.

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The Effect of Cyproheptadine Hydrochloride (Periactin) and Megestrol Acetate (Megace) on Weight in Children With Cancer/Treatment-related Cachexia

Cited by 87 publications

References 43 publications

Benefits associated with escalated begging behaviour of black-billed magpie nestlings overcompensate the associated energetic costs

Benefits associated with escalated begging behaviour of black-billed magpie nestlings overcompensate the associated energetic costs

Safety and Efficacy of a Combination of Cyproheptadine and Tricholine Citrate: Phase IV Study

A Comparative Study of Loratadine Syrup and Cyproheptadine HCL Solution for Treating Perennial Allergic Rhinitis in Taiwanese Children Aged 2–12 Years

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