THE EFFECT OF d-TUBOCURARINE CHLORIDE ON THE BLOOD-PRESSURE OF ANÆSTHETISED PATIENTS

Thomas, E. T.

doi:10.1016/s0140-6736(57)90877-2

Cited by 24 publications

(2 citation statements)

References 14 publications

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“…The blood pressure was observed not to alter significantly in the pancuronium group, which agrees with the findings of McDowall and Clarke (I969), Stoelting (1972), and Nightingale and Bush (973), but there was a significant fall with tubocurarine, which supports the observation of Thomas (1957).…”

Section: Discussionsupporting

confidence: 89%

Effects of general anaesthesia on the intraocular pressure in man. Comparison of tubocurarine and pancuronium in nitrous oxide and oxygen.

Al-Abrak¹,

Samuel²

1974

British Journal of Ophthalmology

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The introduction of new anaesthetic drugs demands that their action should be compared with that of already established agents.Pancuronium bromide was introduced into clinical anaesthetic practice by Baird Material and methodsTen patients undergoing urological surgery (all males aged 3 I to 7 I yrs) were investigated, five being studied for each drug. The nature of the study was explained to each patient and written consent obtained.The methods were similar to those of a previous study by Beaugie and Samuel (I973). The respiratory and cardiovascular status was stabilized by the method of Samuel, Grange, and Hawkins (I968), substituting pancuronium for tubocurarine in the group in which pancuronium was studied.The patients were not premedicated. Either tubocurarine 0-5 mg./kg. body weight, or pancuronium bromide o i mg./kg. were injected intravenously followed by thiopentone 5 mg./kg. and pethidine i o mg./kg. The larynx was sprayed with lignocaine I00 mg. and a cuffed endotracheal tube introduced. Respiration was controlled with a Manley Ventilator set at constant pressure with a constant gas flow of I5 1./min. (nitrous oxide I0 1./min. and oxygen 5 1./min.) to minimize the effects of changes in intrathoracic pressure. The patients lay horizontal throughout the investigation.

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Section: Discussionsupporting

confidence: 89%

Effects of general anaesthesia on the intraocular pressure in man. Comparison of tubocurarine and pancuronium in nitrous oxide and oxygen.

Al-Abrak¹,

Samuel²

1974

British Journal of Ophthalmology

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“…Since the first clinical trials, alcuronium has been considered by some to be the ideal muscle relaxant because of its specificity, reversibility of the neuromuscular block with anticholinesterases, and absence of secondary effects. In particular the effects of alcuronium on arterial pressure and pulse rate have been reported to be insignificant during clinical anaesthesia (Hiigin and Kissling, 1961;Canak, 1965;Ahnefeld, Frey and Halmagyi, 1966), whereas tubocurarine may lower the blood pressure, particularly when given in high doses (Thomas, 1957). Comparative studies of alcuronium and tubocurarine are few (Hunter, 1964;Baraka, 1967) and no report is concerned exclusively with the circulatory effects.…”

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confidence: 99%

The Effect of Alcuronium and Tubocurarine on Blood Pressure and Heart Rate: A Clinical Comparison

Tammisto

Welling

1969

British Journal of Anaesthesia

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The effects of alcuronium (0.15 and 0.3 mg/kg) and tubocurarine (0.3 and 0.6 mg/kg) on arterial pressure and heart rate and rhythm have been compared in forty patients during nitrous oxide, oxygen and pethidine anaesthesia and in twenty patients during nitrous oxide, oxygen and halothane anaesthesia, prior to surgery. When halothane was used only the smaller doses of relaxants were given. Patients were divided into six homologous groups of ten patients. Both relaxants caused a fall in arterial pressure which was more pronounced during halothane anaesthesia. The fall in pressure was equal in degree after both relaxants but the period of maximum lowering was different, being 3-5 minutes after alcuronium and 10-15 minutes after tubocurarine. This difference might be explained by the tubocurarine-induced initial rise in blood pressure which was probably due to pain from venous irritation. Alcuronium had a slight tachycardic effect which was more pronounced during halothane anaesthesia. No e.c.g. changes were seen.

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Arginine vasopressin release following surgical operations

Cochrane

Forsling

Gow

et al. 1981

Journal of British Surgery

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A study of plasma arginine vasopressin (AVP) concentrations in 16 patients undergoing uncomplicated cholecystectomy was carried out to determine the relative importance of the various stimuli to AVP secretion during and after an operation. Eight of the 16 patients were given a high epidural blockade from T4 and T12 and blood samples were taken before, at frequent intervals during and for two days after operation for determination of plasma AVP and osmolarity; systolic blood pressure was measured each time a blood sample was taken. In the 16 patients there was a 1.8-fold rise of plasma AVP after induction of anaesthesia (from 1.7 pmol/l median basal value to 13.1 pmol/l) and an 8.8-fold rise after skin incision, the highest concentration during operation being 102 pmol/l. There was no significant difference in AVP concentrations, urine volumes or plasma osmolality in the control and epidural groups. Systolic blood pressure fell in all patients during operation by between 14 and 54 per cent, the fall being significantly greater in the epidural group. Notwithstanding the evidence that certain nervous impulses do cause an increased secretion of AVP during operation, these results clearly show that in the absence of such stimuli there is still an increased secretion, almost certainly caused by a fall in the blood pressure.

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THE EFFECT OF d-TUBOCURARINE CHLORIDE ON THE BLOOD-PRESSURE OF ANÆSTHETISED PATIENTS

Cited by 24 publications

References 14 publications

Effects of general anaesthesia on the intraocular pressure in man. Comparison of tubocurarine and pancuronium in nitrous oxide and oxygen.

Effects of general anaesthesia on the intraocular pressure in man. Comparison of tubocurarine and pancuronium in nitrous oxide and oxygen.

The Effect of Alcuronium and Tubocurarine on Blood Pressure and Heart Rate: A Clinical Comparison

Arginine vasopressin release following surgical operations

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