The Effect of Davallina Orientalis on Bone Healing — A Preliminary Report

Chow, S. P.; Yeung, H.W.; Law, L. K.; Chan, Tat Ming Danny; Lau, Clara Bik San

doi:10.1142/s0192415x82000166

Cited by 6 publications

(5 citation statements)

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“…Only 25.81% ( n = 8) [22, 32, 37, 38, 42, 46, 48, 49] reported whether the fracture had complete, partial, or absent closure. Other analyses related to bone strength, tensile strength, and expression of inflammatory genes that stimulate bone formation and osteogenic differentiation were performed in 38.71% ( n = 12) of the studies [20, 23, 24, 28, 33, 36, 40–42, 44, 45, 47] (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

Plant Extracts in the Bone Repair Process: A Systematic Review

Miranda

Guimarães-Lopes

Altoé

et al. 2019

Mediators of Inflammation

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Bone lesions are an important public health problem, with high socioeconomic costs. Bone tissue repair is coordinated by an inflammatory dynamic process mediated by osteoprogenitor cells of the periosteum and endosteum, responsible for the formation of a new bone matrix. Studies using antioxidant products from plants for bone lesion treatment have been growing worldwide. We developed a systematic review to compile the results of works with animal models investigating the anti-inflammatory activity of plant extracts in the treatment of bone lesions and analyze the methodological quality of the studies on this subject. Studies were selected in the PubMed/MEDLINE, Scopus, and Web of Science databases according to the PRISMA statement. The research filters were constructed using three parameters: animal model, bone repair, and plant extracts. 31 full-text articles were recovered from 10 countries. Phytochemical prospecting was reported in 15 studies (48.39%). The most common secondary metabolites were flavonoids, cited in 32.26% studies (n = 10). Essential criteria to in vivo animal studies were frequently underreported, suggesting publication bias. The animals treated with plant extracts presented positive results in the osteoblastic proliferation, and consequently, this treatment accelerated osteogenic differentiation and bone callus formation, as well as bone fracture repair. Possibly, these results are associated with antioxidant, regenerative, and anti-inflammatory power of the extracts. The absence or incomplete characterization of the animal models, treatment protocols, and phytochemical and toxicity analyses impairs the internal validity of the evidence, making it difficult to determine the effectiveness and safety of plant-derived products in bone repair.

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Section: Resultsmentioning

confidence: 99%

Plant Extracts in the Bone Repair Process: A Systematic Review

Miranda

Guimarães-Lopes

Altoé

et al. 2019

Mediators of Inflammation

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“…CHMs may exhibit bone protection effect after longterm treatment. Studies have also suggested that CHM may be beneficial for bone metabolism through osteopenia prevention, anti-osteoporotic activities, promotion of fracture healing, and inhibition of inflammation (Chow et al, 1982;Chen et al, 2005;Li et al, 2011;Ma et al, 2011;Xiang et al, 2011;Wong et al, 2013;He and Shen, 2014;Zhang et al, 2016;Hsiao et al, 2017;Wang et al, 2018b;Xi et al, 2018;Lee et al, 2019). Among these studies, there were two review studies reported in human beings.…”

Section: Discussionmentioning

confidence: 99%

“…Chinese herbal medicines (CHMs) are often used to treat bone related diseases, as they show anti-inflammatory, antiosteopenia, anti-osteoporotic, and promote fracture healing activities (Chow et al, 1982;Chen et al, 2005;Li et al, 2011;Ma et al, 2011;Xiang et al, 2011;Shih et al, 2012;Wong et al, 2013;He and Shen, 2014;Mukwaya et al, 2014;Lin et al, 2015;Zhang et al, 2016;Hsiao et al, 2017;Wang et al, 2018b;Xi et al, 2018;Cheng et al, 2019a;Cheng et al, 2019b). However, none of these studies have been carried out in prospective randomized clinical trials in humans.…”

Section: Introductionmentioning

confidence: 99%

Chinese Herbal Medicine Usage Reduces Overall Mortality in HIV-Infected Patients With Osteoporosis or Fractures

et al. 2021

Front. Pharmacol.

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The survival of patients with HIV has greatly improved, due to Anti-Retroviral Therapy (ART). However, long-term HIV survivors often develop serious bone abnormalities, possibly due to the interplay of osteoblasts, osteoclasts, HIV ad ART. We evaluated in a nation-wide study in Taiwan the effect of Chinese herbal medicine (CHM) on overall mortality in HIV patients with osteoporosis or fractures. Enrollment period was between 1998 and 2011. Patients with osteoporosis or fractures before the HIV infection, and those with less than 14 days CHM use, were excluded. This left 498 patients, 160 CHM users, 338 without CHM. Univariate Kaplan-Meier and multivariate Cox regression analysis were used to compare the overall mortality in these 2 groups. Due to the nature of Chinese medicine, CHMs inevitably varied. We therefore also used rule mining and network analysis to determine which major CHM clusters were prescribed to the patients. CHM users had a much Lower mortality (hazard ratio (HR) = 0.43, 95% confidence interval (CI): 0.24–0.77, p < 0.005) and higher survival (p = 0.004, log-rank test). Although the CHMs greatly varied, network analysis identified one main cluster of strongly related CHM combinations (Chuan-Xiong-Cha-Tiao-San (CXCTS), Gan-Cao (GC; Glycyrrhiza uralensis Fisch.), Liu-He-Tang (LHT), Huang-Qin-Tang (HQT), Jia-Wei-Ping-Wei-San (JWPWS), and Dang-Gui-Long-Hui-Wan (DGLHuiW)). CHM as an additional treatment strongly improves overall survival in HIV-infected patients with osteoporosis and fractures.

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“…As CHM is cost-effective with relatively few side effects and has been widely applied for clinical use in Asian countries, it has been previously used for the clinical treatment of osteoporosis and bone fracture in Taiwan (Shih et al, 2012; Liao et al, 2015). Indeed, there are several Chinese herbs that help maintain bone health by regulating bone metabolism (Chow et al, 1982; Chen et al, 2005; Li et al, 2011; Ma et al, 2011; Xiang et al, 2011; Wong et al, 2013; He and Shen, 2014; Zhang et al, 2016; Hsiao et al, 2017; Wang et al, 2018c; Xi et al, 2018). Our pharmacoepidemiologic results have demonstrated that for the patients who were above 60 years old, there was a significant distribution difference in the cumulative overall mortality between CHM and non-CHM users ( Table S3 and Table S4 ).…”

Section: Resultsmentioning

confidence: 99%

“…CHM has also been used to treat bone-related diseases including osteoporosis and bone fractures (Shih et al, 2012; Mukwaya et al, 2014; Liao et al, 2015). CHM is believed to maintain bone health, including: inhibition of inflammation, promotion of fracture healing, osteopenia prevention, and antiosteoporotic activities (Chow et al, 1982; Chen et al, 2005; Li et al, 2011; Ma et al, 2011; Xiang et al, 2011; Wong et al, 2013; He and Shen, 2014; Zhang et al, 2016; Hsiao et al, 2017; Wang et al, 2018c; Xi et al, 2018; Lee et al, 2019). These studies have encouraged the search for complementary therapy for the better management of bone-related diseases.…”

Section: Introductionmentioning

confidence: 99%

Effects of Chinese Herbal Medicines on the Risk of Overall Mortality, Readmission, and Reoperation in Hip Fracture Patients

et al. 2019

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Hip fracture is a major public health concern, with high incidence rates in the elderly worldwide. Hip fractures are associated with increased medical costs, patient dependency on families, and higher rates of morbidity and mortality. Chinese herbal medicine (CHM) is typically characterized as cost-effective and suitable for long-term use with few side effects. To better understand the effects of CHM on hip fracture patients, we utilized a population-based database to investigate the demographic characteristics, cumulative incidence of overall mortality, readmission, reoperation, and patterns of CHM prescription. We found that CHM usage was associated with a lower risk of overall mortality [ P = 0.0009; adjusted hazard ratio (HR): 0.47, 95% confidence interval (CI): 0.30–0.73], readmission ( P = 0.0345; adjusted HR: 0.67, 95% CI: 0.46–0.97), and reoperation ( P = 0.0009; adjusted HR: 0.57, 95% CI: 0.40–0.79) after adjustment for age, type of hip fracture, surgical treatment type, and comorbidities. We also identified the herbal formulas, single herbs, and prescription patterns for the treatment of hip fracture by using association rule mining and network analysis. For hip fracture patients, the most common CHM coprescription pattern was Du-Zhong (DZ) → Xu-Duan (XD), followed by Du-Huo-Ji-Sheng-Tang (DHJST) → Shu-Jing-Huo-Xue-Tang (SJHXT), and Gu-Sui-Bu (GSB) → Xu-Duan (XD). Furthermore, XD was the core prescription, and DZ, GSB, SJHXT, and DHJST were important prescriptions located in cluster 1 of the prescription patterns. This study provides evidence for clinical CHM use as an adjunctive therapy that offers benefits to hip fracture patients.

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The Effect of Davallina Orientalis on Bone Healing — A Preliminary Report

Cited by 6 publications

References 0 publications

Plant Extracts in the Bone Repair Process: A Systematic Review

Plant Extracts in the Bone Repair Process: A Systematic Review

Chinese Herbal Medicine Usage Reduces Overall Mortality in HIV-Infected Patients With Osteoporosis or Fractures

Effects of Chinese Herbal Medicines on the Risk of Overall Mortality, Readmission, and Reoperation in Hip Fracture Patients

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