The effect of DDT on the level of Di- and triphosphopyridine nucleotides in Triatoma infestans

Agosín, Manuel R.; Dinamarca, Maria Luisa

doi:10.1016/0014-4894(63)90071-7

Cited by 13 publications

(5 citation statements)

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“…DDT exposure have been demonstrated to enhance mixed function oxidases (MFO) in T. infestans in the 60's by Agosin and Dinamarca (1963) and Agosin et al (1969). DDT was also found to be most active in causing GST activity induction (150%) in Musca domestica (Hayaoka & Dauterman 1982).…”

Section: Discussionmentioning

confidence: 99%

“…Probably the first reports of induction in insects were those of Agosin and Dinamarca (1963) who observed the phenomenon in Triatoma infestans, a blood-sucking insect, when this species was treated with DDT [1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane]. They found that DDT increased the level of nicotinamide adenine dinucleotide phosphate (NADP), which is an important cofactor in microsomal oxidation.…”

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confidence: 99%

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Induction of Glutathione S-transferase Activity in Triatoma infestans

Sívori¹,

Casabé²,

En³

et al. 1997

Mem. Inst. Oswaldo Cruz

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Induction of Glutathione S-transferase Activity in Triatoma infestans

Sívori¹,

Casabé²,

En³

et al. 1997

Mem. Inst. Oswaldo Cruz

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“…Induction of detoxification enzymes in response to environmental xenobiotics have also been documented in insects. The first documented evidence of enzyme induction in insects was given by Agnosin and Dinamarca, (1963) in which they reported an increased activity of NAD kinase in Triatoma infestans after exposure to DDT. Cytochrome P450s have featured more prominently in many previous studies involving induction of detoxification enzymes in response to environmental xenobiotics in insects, relative to GST and α and β-esterases (Le Goff et al, 2006) In general, induction of detoxification enzymes in response to several xenobiotic exposures in many insect species have been well documented (David et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…However, evidences have emerged that insects like other higher animals have the ability to regulate the transcription of detoxification genes in response to environmental xenobiotics. The first documented evidence of enzyme induction in insects was given by Agnosin and Dinamarca (1963), in which they reported an increased activity of NAD Kinase in Triatoma infestans after exposure to DDT.…”

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confidence: 99%

Response of <i>Anopheles gambiae</i> detoxification enzymes to levels of physico-chemical environmental factors from northwest Nigeria

Abdullahi¹,

Yusuf²

2015

Bayero J. Pure App. Sci.

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The objective of this study was to investigate the response of Anopheles gambiae detoxification enzymes to levels of various physico-chemical environmental factors present in their breeding sites. Mosquito breeding sites were grouped into three different breeding sites (designated as study zones A, B & C) on the bases of human related activities (intensive agriculture, petrochemical and domestic) taking place within and/or around the breeding sites, followed by sampling of Anopheles gambiae larvae from all the breeding sites across the designated study zones. Some of the sampled larvae were reared to pupae and adult life stages. Levels of 7 physical (pH, temperature, conductivity, transparency, total dissolved solids, dissolved oxygen and biological oxygen demand) and 6 chemical (sulphates, phosphates, nitrites, nitrates, carbon content and oil and grease) environmental factors were determined from these mosquito breeding sites. Activities of the 3 major detoxification enzymes (Cytochrome P450 oxygenase, GST and α & β-esterases) were evaluated in the sampled larvae as well as the pupae and adult samples that ultimately emerged from the larvae. Following statistical analysis, results showed that P450 activities were higher in the petrochemical sites (zone C) and the activities were highly associated with pH, temperature as well as carbon content and oil and grease. The activities of GST and α & βesterases were higher in the intensive agriculture sites (Zone A) and were highly correlated with all the chemicals environmental factors. A deduced statistical model established all the chemical in combination with some of the physical environmental factors as producing an inductive effect on these three detoxification enzymes. These observations could have a significant impact on the insecticide-based approach to vector control. An. gambiae samples may have developed intrinsic enzymatic machinery to produce an adaptive tolerance to various insecticides used for their control since most of these insecticides and the environmental chemical factors share similar routes of metabolism.

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“…Probably the first reports of induction in insects were those of Agosin and coworkers (Agosin and Dinamarca, 1963) who observed the phenomenon in Triatoma infes-Departments of Agricultural Chemistry and Entomology, Oregon State University, Corvallis, Oregon 97331. tans, a blood-sucking insect, when this species was treated with DDT. They found that DDT increased the level of NADP, which is an important cofactor in microsomal oxidation.…”

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confidence: 99%