The effect of Dean, Reynolds and Womersley numbers on the flow in a spherical cavity on a curved round pipe. Part 1. Fluid mechanics in the cavity as a canonical flow representing intracranial aneurysms

Chassagne, Fanette; Barbour, Michael; Chivukula, Venkat Keshav; Machicoane, Nathanaël; Kim, Louis J.; Levitt, Michael R.; Aliseda, Alberto

doi:10.1017/jfm.2020.1114

Cited by 14 publications

(25 citation statements)

References 36 publications

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“…The velocity field was measured by stereo-PIV. The fluid was seeded with 10 µm hollow glass spheres (TSI, Shoreview, MN), 24,32 scattering light from a sheet created by a pulsed laser (TerraPIV, Continuum, San Jose, CA). The light ( λ = 527 nm) scattered by the particles was recorded by two high-speed cameras (VEO 640, Vision Research, Wayne, NJ), synchronized with the laser pulses (Frame rate = 200 Hz; false Δt=[350,450] μnormals depending on experimental conditions).…”

Section: Methodsmentioning

confidence: 99%

In Vitro Investigation of the Effect of the Timing of Left Ventricular Assist Device Speed Modulation on Intraventricular Flow Patterns

Chassagne

Beckman

et al. 2023

ASAIO Journal

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Thromboembolic events remain a common complication for left ventricular assist device (LVAD) patients. To prevent inpump thrombosis, third-generation LVADs use speed modulation, which is not synchronized with the native left ventricle (LV) contractility. This study aims to investigate the effect of speed modulation on intraventricular flow patterns, and specifically, the impact of timing relative to pressure variations in the LV. Stereo-particle image velocimetry measurements were performed in a patient-derived LV implanted with an LVAD, for different timings of the speed modulation and speed. Speed modulation has a strong effect on instantaneous afterload and flowrate (-16% and +20%). The different timings of the speed modulation resulted in different flowrate waveforms, exhibiting different maxima (5.3-5.9 L/min, at constant average flowrate). Moreover, the timing of the speed modulation was found to strongly influence intraventricular flow patterns, specifically, stagnation areas within the LV. These experiments highlight, once more, the complex relationship between LVAD speed, hemodynamic resistance, and intraventricular pressure. Overall, this study demonstrates the importance of considering native LV contractility in future LVAD controls, to improve hemocompatibility and reduce the risk of thromboembolic complications.

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Section: Methodsmentioning

confidence: 99%

In Vitro Investigation of the Effect of the Timing of Left Ventricular Assist Device Speed Modulation on Intraventricular Flow Patterns

Chassagne

Beckman

et al. 2023

ASAIO Journal

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“…2021; Chassagne et al. 2021), the volume of the aneurysmal sac was kept constant. The sac aspect ratio, defined as , was 0.4–1.6 ( corresponding to the spherical geometry in the previous study) (figure 1).…”

Section: Experimental Methodsmentioning

confidence: 99%

“…A full description of the optical set-up can be found in Chassagne et al. (2021). This approach provided 7653 image pairs for each experimental condition (), achieving fully converged phase-averaged statistics.…”

Section: Experimental Methodsmentioning

confidence: 99%

“…The location of the centre of the vortex was estimated with the location of the minimum velocity magnitude in the cavity (Chassagne et al. 2021).…”

Section: Experimental Methodsmentioning

confidence: 99%

“…2021; Chassagne et al. 2021). The present study investigates the effect of geometrical parameters (neck size, sac aspect ratio and parent vessel curvature) and haemodynamics parameters ( and Womersley numbers).…”

Section: Introductionmentioning

confidence: 99%

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Fluid dynamics in intracranial aneurysms treated with flow-diverting stents: effect of multiple geometrical parameters

Chassagne,

Barbour,

Levitt

et al. 2023

J. Fluid Mech.

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Characterizing the haemodynamics in intracranial aneurysms is of high interest as it impacts aneurysm growth, rupture and treatment, especially with flow-diverting stents (FDS). Flow in these geometries is known to depend on the Dean, Reynolds and Womersley numbers, $De$ , $Re$ , $Wo$ , but is also influenced by geometrical parameters such as the sac shape or the size of the opening. Via particle image velocimetry, this parametric study aimed at evaluating the combined effects of $Re$ , $De$ , $Wo$ and the geometry of the aneurysmal sac on the haemodynamics before and after treatment with FDS. Eight ellipsoidal idealized aneurysm models were created with two curvatures of the parent vessel, two aspect ratios of the sac and two neck sizes. Before treatment, a single counter-rotating vortex, whose strength increases with $Re$ and $De$ , as well as with the neck size and the aspect ratio, was observed in the sac for all but one geometry. After treatment with FDS, four different flow topologies were observed, depending on the geometry: no separation, separation for part of the cycle, two opposing vortices or a single counter-rotating vortex. A linear model with interaction revealed the predominant effect of $De$ and the curvature of the parent vessel on the haemodynamics before and after treatment. This work once more demonstrated the primary role of haemodynamics in the treatment of intracranial aneurysms with FDS. Future work will consider the complexity of patient-specific geometries, and their effects on both the haemodynamics in the sac and the porosity of the FDS.

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Transient flow patterns of start-up flow in round microcavities

Shen

Zhao

et al. 2022

Microfluid Nanofluid

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The effect of Dean, Reynolds and Womersley numbers on the flow in a spherical cavity on a curved round pipe. Part 1. Fluid mechanics in the cavity as a canonical flow representing intracranial aneurysms

Abstract: Abstract

Cited by 14 publications

References 36 publications

In Vitro Investigation of the Effect of the Timing of Left Ventricular Assist Device Speed Modulation on Intraventricular Flow Patterns

In Vitro Investigation of the Effect of the Timing of Left Ventricular Assist Device Speed Modulation on Intraventricular Flow Patterns

Fluid dynamics in intracranial aneurysms treated with flow-diverting stents: effect of multiple geometrical parameters

Transient flow patterns of start-up flow in round microcavities

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