The effect of decaffeination of coffee on gastro‐oesophageal reflux in patients with reflux disease

Abstract

Background: Patients with reflux disease often complain of heartburn after ingestion of coffee. Induction of gastro‐oesophageal reflux has been demonstrated by pH‐metry following the intake of coffee in healthy volunteers. The reflux was reduced when the coffee had undergone a decaffeination process. The aim of this study was to investigate the effect of decaffeination of coffee on reflux in patients with reflux disease. Methods: Seventeen reflux patients underwent two oesophageal 3‐h pH measurements. The patients received, in a double‐blind study design in a randomized order, 300 mL of either regular or decaffeinated coffee together with a standardized breakfast. The fraction time oesophageal pH < 4 was calculated during the three postprandial hours. Results: For regular coffee the fraction time was calculated to a median of 17.9% with a range of 0.7–56.6%. The fraction time was significantly reduced to 3.1% (0–49.9%) after ingestion of decaffeinated coffee. Conclusion: The amount of gastro‐oesophageal reflux induced by the intake of regular coffee in patients with reflux disease can be reduced by the decaffeination of coffee.

Quantitation of βN-Alkanoyl-5-hydroxytryptamides in Coffee by Means of LC-MS/MS-SIDA and Assessment of Their Gastric Acid Secretion Potential Using the HGT-1 Cell Assay

“…Addition of petroleum ether (20 mL) led to the precipitation of the target compounds which were isolated by centrifugation and recrystallized from methanol, yielding the β N-d 2 -alkanoyl-5-hydroxytryptamides in a purity of more than 99% (LC-MS, 1 m/z (%) 160.1 (100), 177 (12). 1 H NMR (400 MHz, d 6 -DMSO): δ/ppm 0.84 (t, 3H, J = 7.1 Hz, H-C(28)), 1.15-1.30 (m, 12 Â 2H, 2 Â 1H, H-C (14)(15)(16)(17)(18)(20)(21)(22)(23)(24)(25)(26)(27), H-C (19,20)), 1.47 (m, 2H, H-C(13)), 2.03 (t, 2H, J = 7.4 Hz, H-C(12)), 2.69 (t, 2H, J = 7.4 Hz, H-C(8)), 3.25 (q, 2H, J = 6.6 Hz, H-C(9)), 6.56 (dd, 1H, J = 8.56 Hz, J = 2.02 Hz, H-C(6)), 6.80 (d, 1H, J = 2.02 Hz, H-C(4)), 6.99 (d, 1H, J = 1.77 Hz, H-C(2)), 7.10 (d, 1H, J = 8.6 Hz, H-C(7)), 7.82 (t, 1H, J = 5.56 Hz, H-N(10)), 8.54 (s, 1H, HO-C(5)), 10.44 (d, 1H, J = 1.77 Hz, H-N(1)). 13 C NMR (100 MHz, d 6 -DMSO): δ/ppm 14.08 (CH 3 , C(28)), 25.35 (CH 2 , C(8,13)), 22.17-34.47 (CDH, CH 2 , C(14-27)), 35.53 (CH 2 , C(12)), 39.75 (CH 2 , C(9)), 102.66 (CH, C(4)), 111.80 (CH, C(6,7)), 112.66 (C, C(3)), 123.39 (CH, C(2)), 128.06 (C, C(3 0 )), 131.07 (C, C(7 0 )), 150.84 (C-OH, C(5)), 172.32 (CdO, C(11)).…”

Latin American Consensus on Gastroesophageal Reflux Disease: An Update on Therapy

“…raising the bed head during sleep) were published during the review period. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] Impact on recommendations: None. Recommendation: The recommendation is unchanged with respect to the 2004 Consensus (see Table 2) 2.…”

Benefícios do café na saúde: mito ou realidade?

“…109,110 Pensa-se que tal efeito poderá ter como base uma irritação directa da mucosa esofágica ou um fomento do refluxo gastro-esofágico. 111 De facto, alguns estudos mostram que, comparativamente com a ingestão de água, o café e o descafeinado provocam um aumento desse refluxo, [112][113][114] estimulando também a secreção ácida estomacal. [115][116][117][118][119] Não foi demonstrada qualquer associação entre o consumo de café e o desenvolvimento de úlcera péptica, 111 mas verificou-se que pacientes com úlcera duodenal alteraram os seus hábitos de consumo de café devido à ocorrência de dispepsia.…”