The effect of deoxycorticosterone on the undirectional transfers of sodium and potassium into and out of the dog intestine

Berger, Eugene Y.; Kanzaki, Grace; Steele, J. Murray

doi:10.1113/jphysiol.1960.sp006443

Cited by 36 publications

(13 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…'Unidirectional flux' is defined as stated above. 'Influx' is defined as flow from lumen to plasma and 'efflux' as flow from plasma to the lumen (these definitions are the reverse of those of Berger et al 1960). The terms 'absorption' denoting a net decrease and 'secretion' a net increase in luminal content of water or electrolyte are used in the customary sense and these definitions are similar to those of Berger et al (1960).…”

Section: Methodsmentioning

confidence: 99%

“…Visscher, Varco, Carr, Dean & Erickson, 1944;Curran & Solomon, 1957). Berger, Kanzaki & Steele (1960), for example, defined 'undirectional flux' in the generally accepted manner as the one-way passage of electrolyte from one side of the intestinal mucosa to the other, but proceeded to use the term 'influx' as denoting flow into and 'efflux' as flow out of the intestinal lumen. Thus, the terms were transferred from isotope fluxes to ionic fluxes, 24Na efflux, for example, becoming Na efflux.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Transport of sodium and secretion of potassium and bicarbonate by the colon of normal and sodium‐depleted rats

Edmonds¹

1967

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. Ascending and descending colonic segments of normal and Nadepleted rats were perfused in vivo with isotonic solutions of varying Na concentration and the unidirectional Na fluxes and secretion rate of K and bicarbonate and the transmucosal electrical p.d. were measured.2. Potential difference was greater in Na-depleted rats, especially towards the distal end of the descending colon. With reduction of luminal Na concentration, p.d. was reduced.3. The ascending and descending segments were similar in regard to Na transport except that the latter had lower passive permeability. Na depletion caused an increase of Na influx rate, Na net flux rate and Na exchange diffusion whilst the mucosal passive Na permeability decreased. These changes resulted in a reduction in the critical luminal Na concentration, i.e. the concentration at which the unidirectional fluxes were equal.4. K secretion rate was similar in the ascending and descending colon and was increased by Na depletion. In all rats, it was reduced when the luminal Na concentration was low.5. Bicarbonate secretion rate was unaffected by the Na depletion and all solutions remained isotonic during perfusion.6. The results confirmed that active Na transport was stimulated by Na depletion but indicated that this was probably not the only factor in the elevation of transmucosal p.d.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Transport of sodium and secretion of potassium and bicarbonate by the colon of normal and sodium‐depleted rats

Edmonds¹

1967

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…Whether a similar relationship between Na-K-ATPase and electrolyte transport exists in the intestine is not known. Adrenocorticosteroids have been shown to enhance colonic sodium absorption, potassium secretion, and transmural potential difference (PD)1 (9)(10)(11)(12)(13). Except for a single report (14), however, effects on colonic Na-K-ATPase have not been studied.…”

Section: Introductionmentioning

confidence: 99%

Na+-K+-activated adenosine triphosphatase and intestinal electrolyte transport. Effect of adrenal steroids.

Charney¹,

Kinsey²,

Myers³

et al. 1975

J. Clin. Invest.

169

View full text Add to dashboard Cite

A B S T R A C T Sodium-potassium-activated adenosine triphosphatase (Na-K-ATPase) is associated with electrolyte transport in many tissues. To help delineate its role in intestinal transport, changes in rat intestinal electrolyte and water transport induced by injecting methylprednisolone acetate 3 mg/100 g or deoxycorticosterone acetate (DOCA) 0.5 mg/100 g per day for 3 days were correlated with changes in Na-K-ATPase activity. Methylprednisolone increased sodium and water absorption, potassium secretion, transmural potential difference, and Na-K-ATPase activity in the jejunum, ileum, and colon. Examination of isolated epithelial cells demonstrated that the jejunal and ileal increase in Na-K-ATPase occurred in both the villus tip and crypt areas. The time-courses of the ileal enzyme and transport changes were identical. Permeability, Mg-ATPase, and adenylate cyclase activities were unchanged by methylprednisolone. DOCA increased sodium and water absorption, potassium secretion, transmural potential difference, and Na-K-ATPase activity in the colon alone. Colonic Mg-ATPase and adenylate cyclase activities were unaffected. Jejunal and ileal enzyme activity, electrolyte transport, and permeability were unchanged by DOCA. Methylprednisolone and DOCA were not additive in their effect on colonic Na-K-ATPase activity. Methylprednisolone and DOCA increased electrolyte and water transport and Na-K-ATPase activity concomitantly in specific segments of small intestine and colon. These data are consistent with an important role for Na-K-ATPase in intestinal electrolyte and water transport.

show abstract

“…In patients with Addison's disease, the fecal sodium loss could also be reduced by desoxycorticosterone (12). Berger, Kanzaki, and Steele showed that the rate of sodium absorption from the colon of dogs was increased after desoxycorticosterone administration (18). Shields and Elmslie (19) demonstrated an increase in potassium secretion into isolated segments of ileum and colon after intravenous administration of aldosterone to dogs.…”

mentioning

confidence: 98%

“…Whether aldosterone influences sodium absorption from the human intestine has not been directly measured but has been postulated on the basis of indirect evidence and animal studies (5,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Berger and Steele (11) demonstrated that the amount of sodium removed from the gut when a cation exchange resin was fed orally was considerably less in patients with congestive heart failure and decompensated cirrhosis (both conditions in which aldosterone secretion is increased) than in normal controls.…”

mentioning

confidence: 99%

Effect of d-Aldosterone on Salt and Water Absorption from the Intact Human Colon*

Levitan¹,

Ingelfinger²

1965

J. Clin. Invest.

133

View full text Add to dashboard Cite

The effect of deoxycorticosterone on the undirectional transfers of sodium and potassium into and out of the dog intestine

Cited by 36 publications

References 26 publications

Transport of sodium and secretion of potassium and bicarbonate by the colon of normal and sodium‐depleted rats

Transport of sodium and secretion of potassium and bicarbonate by the colon of normal and sodium‐depleted rats

Na+-K+-activated adenosine triphosphatase and intestinal electrolyte transport. Effect of adrenal steroids.

Effect of d-Aldosterone on Salt and Water Absorption from the Intact Human Colon*

Contact Info

Product

Resources

About