The Effect of Depo Medroxyprogesterone Acetate (DMPA) on Cerebral Food Motivation Centers: A Pilot Study using Functional Magnetic Resonance Imaging

Basu, Tania; Bao, Peng; Anderson, Lindsey; Page, Kathleen A.; Stanczyk, Frank Z.; Mishell, Daniel R.; Segall-Gutierrez, Penina

doi:10.1016/j.contraception.2016.04.011

Cited by 9 publications

(4 citation statements)

References 26 publications

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“…Our search identified 59 eligible studies (total m = 59) [ 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 ,…”

Section: Resultsunclassified

Brain Responses to High-Calorie Visual Food Cues in Individuals with Normal-Weight or Obesity: An Activation Likelihood Estimation Meta-Analysis

Yang

Morys

2021

Brain Sciences

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Overconsumption of high-calorie or unhealthy foods commonly leads to weight gain. Understanding people’s neural responses to high-calorie food cues might help to develop better interventions for preventing or reducing overeating and weight gain. In this review, we conducted a coordinate-based meta-analysis of functional magnetic resonance imaging studies of viewing high-calorie food cues in both normal-weight people and people with obesity. Electronic databases were searched for relevant articles, retrieving 59 eligible studies containing 2410 unique participants. The results of an activation likelihood estimation indicate large clusters in a range of structures, including the orbitofrontal cortex (OFC), amygdala, insula/frontal operculum, culmen, as well as the middle occipital gyrus, lingual gyrus, and fusiform gyrus. Conjunction analysis suggested that both normal-weight people and people with obesity activated OFC, supporting that the two groups share common neural substrates of reward processing when viewing high-calorie food cues. The contrast analyses did not show significant activations when comparing obesity with normal-weight. Together, these results provide new important evidence for the neural mechanism underlying high-calorie food cues processing, and new insights into common and distinct brain activations of viewing high-calorie food cues between people with obesity and normal-weight people.

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Section: Resultsunclassified

Brain Responses to High-Calorie Visual Food Cues in Individuals with Normal-Weight or Obesity: An Activation Likelihood Estimation Meta-Analysis

Yang

Morys

2021

Brain Sciences

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“…fMRI activation in the HC group was similar to that of the luteal phase in the NC women. Food related brain activation was assessed also by Basu et al (2016) who tested the effects of depot medroxyprogesterone acetate (DMPA) on food motivation using a quasi-experimental pre-post design with subjects acting as their own controls. Eight women were investigated with MRI while looking at images of high-calorie and low-calorie foods, as well as neutral, nonfood objects.…”

Section: Reward and Motivationmentioning

confidence: 99%

“…This remains speculative but should be explored further due to the seriousness of the potential consequences. The studies on sexual, monetary and food-related rewards (Abler et al, 2013;Bonenberger et al, 2013;Basu et al, 2016) suffer from possible retest effects in only some of the subjects, post-hoc finding present only in an ROI based analysis and a small sample, respectively, thus presenting with reduced validity.…”

Section: Implications Of Structural and Functional Alterationsmentioning

confidence: 99%

The Effects of Hormonal Contraceptives on the Brain: A Systematic Review of Neuroimaging Studies

et al. 2020

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Background: Hormonal contraceptive drugs are being used by adult and adolescent women all over the world. Convergent evidence from animal research indicates that contraceptive substances can alter both structure and function of the brain, yet such effects are not part of the public discourse or clinical decision-making concerning these drugs. We thus conducted a systematic review of the neuroimaging literature to assess the current evidence of hormonal contraceptive influence on the human brain. Methods: The review was registered in PROSPERO and conducted in accordance with the PRISMA criteria for systematic reviews. Structural and functional neuroimaging studies concerning the use of hormonal contraceptives, indexed in Embase, PubMed and/or PsycINFO until February 2020 were included, following a comprehensive and systematic search based on predetermined selection criteria. Results: A total of 33 articles met the inclusion criteria. Ten of these were structural studies, while 23 were functional investigations. Only one study investigated effects on an adolescent sample. The quality of the articles varied as many had methodological challenges as well as partially unfounded theoretical claims. However, most of the included neuroimaging studies found functional and/or structural brain changes associated with the use of hormonal contraceptives. Conclusion: The included studies identified structural and functional changes in areas involved in affective and cognitive processing, such as the amygdala, hippocampus, prefrontal cortex and cingulate gyrus. However, only one study reported primary research on a purely adolescent sample. Thus, there is a need for further investigation of the implications of these findings, especially with regard to adolescent girls.

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“…Fasting glucose increased and insulin sensitivity decreased more with the ETG implant than with the LNG-IUS when compared to a non-hormonal method. An eight-week study examined DMPA effects on food motivation centers in the brain (Basu 2016). Eight of 14 women completed the protocol with data for analysis.…”

Section: Introductionmentioning

confidence: 99%

Progestin-only contraceptives: effects on weight

Lopez

Ramesh

Chen

et al. 2016

Cochrane Database of Systematic Reviews

113

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The Effect of Depo Medroxyprogesterone Acetate (DMPA) on Cerebral Food Motivation Centers: A Pilot Study using Functional Magnetic Resonance Imaging

Cited by 9 publications

References 26 publications

Brain Responses to High-Calorie Visual Food Cues in Individuals with Normal-Weight or Obesity: An Activation Likelihood Estimation Meta-Analysis

Brain Responses to High-Calorie Visual Food Cues in Individuals with Normal-Weight or Obesity: An Activation Likelihood Estimation Meta-Analysis

The Effects of Hormonal Contraceptives on the Brain: A Systematic Review of Neuroimaging Studies

Progestin-only contraceptives: effects on weight

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