The effect of dermoscopy in assisting on defining surgical margins of basal cell carcinoma

Chen, Wei; Liu, Zhen-ru; Zhou, Yuan; Liu, Meng-Xi; Wang, Xiaoqing; Wang, Daguang

doi:10.1111/dth.15711

Cited by 8 publications

(2 citation statements)

References 27 publications

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“…In our study, we made a distinction between arborized vessels and short, fine telangiectasias. Arborized vessels were frequently detected in all subtypes of BCC, but short, fine telangiectasias were specific for superficial BCC ( p < 0.05); a similar aspect was also observed by Chen W et al [ 24 ]. The maple-leaf-like areas and spoke-wheel areas pigmented patterns were most frequently found to be associated with superficial BCC ( p < 0.01).…”

Section: Discussionsupporting

confidence: 78%

Advancements in Basal Cell Carcinoma Diagnosis: Non-Invasive Imaging and Multimodal Approach

Negrutiu,

Danescu,

Popa

et al. 2023

JCM

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(1) Background: The aim of this study was to correlate the diagnostic criteria described in dermatoscopy, ultrasonography (US), ex vivo confocal microscopy, and histology to the most common subtypes of basal cell carcinoma (BCC). (2) Methods: We conducted a prospective study including 46 BCC cases, which were analyzed with dermatoscopy using the Delta 30 dermatoscope and Vidix 4.0 videodermoscope, with US using a high-resolution 20 MHz linear probe, with confocal microscopy, along with histopathological analysis. (3) Results: This study categorized BCC by histological subtype, with nodular being the most common (84.8%) and various other subtypes represented. US measurements of tumor thickness correlated strongly with the histopathological depth of invasion index (DI). Dermatoscopy analysis revealed significant associations between specific features and BCC subtypes. The DI was directly related to arborized vessels but inversely related to short, fine telangiectasias, maple-leaf-like areas, and spoke-wheel areas. The presence of ulceration was directly related to the DI. Confocal microscopy images exhibited several characteristics, including fluorescence, nuclear crowding, peripheral palisading, clefting, increased nuclear–cytoplasmic (N/C) ratio, and a “cauliflower-like” appearance. (4) Conclusion: The advanced detection of BCC through imagistic techniques like dermatoscopy, confocal microscopy, and ultrasound improves the diagnosis and may offer valuable insights for treatment in the future by evaluating lesion characteristics.

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Section: Discussionsupporting

confidence: 78%

Advancements in Basal Cell Carcinoma Diagnosis: Non-Invasive Imaging and Multimodal Approach

Negrutiu,

Danescu,

Popa

et al. 2023

JCM

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“…Thus, dermoscopy can be employed as a reliable tool for choosing the optimal therapeutic approach in BCC. Moreover, it allows a more accurate evaluation of excision margins and, if a nonablative treatment method was implemented, dermoscopy can be used for the assessment of the therapeutic response (38)(39)(40)(41).…”

mentioning

confidence: 99%

Editorial: Recent advances in keratinocyte carcinomas: From molecular mechanisms to clinical perspectives

et al. 2022

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Editorial on the Research TopicRecent advances in keratinocyte carcinomas: From molecular mechanisms to clinical perspectives Keratinocyte carcinomas (KCs), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common forms of cancer worldwide, and their incidence is showing a rapidly increasing trend in the last years (1, 2). Moreover, they are still associated with significant morbidity and mortality, even if the progress in diagnosis and treatment of keratinocyte-derived tumors is substantial (3-7). Hence, KCs emerged as an important topic of scientific interest and recent advances have been achieved.In their paper, Kavasi et al. have reviewed impactful information regarding the structural and functional modulations of the KCs microenvironment. Moreover, the impact of extracellular matrix remodeling on the pathogenesis of non-melanoma skin cancers (NMSCs) was also discussed. The alteration of collagen matrix in NMSCs and the role of proteoglycans as mediators of tumor progression in KCs were emphasized, as well as the regulatory functions of matrix metalloproteinases (MMPs) in the tumor microenvironment. Especially the involvement of MMPs in the immune and inflammatory mechanisms in NMSCs has attracted the researchers' attention (8-13). Another important aspect regards the immune cells infiltrating the tumor microenvironment in KCs. In both BCC and SCC have been emphasized specific patterns of tumor infiltrating lymphocytes carrying prognostic significance (14-19). Moreover, alterations in circulatory MMPs and immune and inflammatory related elements were identified in NMSCs and could be used as potential markers for invasiveness and tumor progression (10, 20,21). Thus, more and more information suggests the possible Frontiers in Medicine frontiersin.org

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Novel imaging techniques for tumor margin detection in basal cell carcinoma: a systematic scoping review of FDA and EMA‐approved imaging modalities

Boostani,

Bozsányi,

Suppa

et al. 2024

Int J Dermatology

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Mohs micrographic surgery (MMS) is the gold standard for removing basal cell carcinomas (BCCs) due to its ability to guarantee 100% margin evaluation through frozen section histopathology, offering the highest cure rate among current treatments. However, noninvasive imaging technologies have emerged as promising alternatives to clinical assessment for defining presurgical margins. This systematic scoping review examines the efficacy of these imaging modalities, focusing on those approved for clinical use by the United States Food and Drug Administration (FDA) or the European Medicines Agency (EMA). A systematic search of EMBASE, Scopus, PubMed, and the Cochrane Public Library databases identified 11 relevant studies out of 2123 records, encompassing 644 lesions across five imaging techniques. The findings suggest that dermoscopy, high‐frequency ultrasound (HFUS), optical coherence tomography (OCT), line‐field optical coherence tomography (LC‐OCT), and reflectance confocal microscopy (RCM) show potential in detecting BCC margins, which could enhance MMS by providing better preoperative planning, informing patients of expected defect size, aiding in reconstruction decisions, and reducing overall procedure costs. This review discusses the benefits and limitations of each technique, offering insights into how these innovations could influence the future of BCC management. Emerging imaging techniques could enhance MMS by improving BCC margin assessment and reducing costs. Their adoption will depend on price and ease of use.

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The effect of dermoscopy in assisting on defining surgical margins of basal cell carcinoma

Cited by 8 publications

References 27 publications

Advancements in Basal Cell Carcinoma Diagnosis: Non-Invasive Imaging and Multimodal Approach

Advancements in Basal Cell Carcinoma Diagnosis: Non-Invasive Imaging and Multimodal Approach

Editorial: Recent advances in keratinocyte carcinomas: From molecular mechanisms to clinical perspectives

Novel imaging techniques for tumor margin detection in basal cell carcinoma: a systematic scoping review of FDA and EMA‐approved imaging modalities

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