The effect of DHEA on apoptosis and cohesin levels in oocytes in aged mice

Chu, Nan; Gui, Yuyan; Zhang, Na; Li, Lisha; Li, Da‐Jin; Tang, Wei; Gober, Hans-Jürgen; Zhang, Bin; Wang, Ling

doi:10.5582/bst.2017.01108

Cited by 10 publications

(4 citation statements)

References 64 publications

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“…Finally, DHEA and androgens require a fine balance to prevent hyperandrogenism. Chu et al [ 90 ] mentioned that the androgenic effects of DHEA are rather weak compared to testosterone. However, we would still caution against their use in young patients.…”

Section: Discussionmentioning

confidence: 99%

“…Given that it is the precursor to sex hormones, its age-related decline has been hypothesised to influence fertility. One study looked at DHEA supplementation in mice near menopause [ 90 ]. The study indeed found that the group of mice supplemented with DHEA had significantly higher primordial, primary and secondary follicle counts compared to the control.…”

Section: Potential Molecular/metabolic Treatments For Prevention Of O...mentioning

confidence: 99%

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Metabolic Mechanisms and Potential Therapeutic Targets for Prevention of Ovarian Aging: Data from Up-to-Date Experimental Studies

Valtetsiotis

Valsamakis

Charmandari

et al. 2023

IJMS

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Female infertility and reproduction is an ongoing and rising healthcare issue, resulting in delaying the decision to start a family. Therefore, in this review, we examine potential novel metabolic mechanisms involved in ovarian aging according to recent data and how these mechanisms may be addressed through new potential medical treatments. We examine novel medical treatments currently available based mostly on experimental stem cell procedures as well as caloric restriction (CR), hyperbaric oxygen treatment and mitochondrial transfer. Understanding the connection between metabolic and reproductive pathways has the potential to offer a significant scientific breakthrough in preventing ovarian aging and prolonging female fertility. Overall, the field of ovarian aging is an emerging field that may expand the female fertility window and perhaps even reduce the need for artificial reproductive techniques.

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Section: Discussionmentioning

confidence: 99%

Section: Potential Molecular/metabolic Treatments For Prevention Of O...mentioning

confidence: 99%

Metabolic Mechanisms and Potential Therapeutic Targets for Prevention of Ovarian Aging: Data from Up-to-Date Experimental Studies

Valtetsiotis

Valsamakis

Charmandari

et al. 2023

IJMS

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“…miR-182, miR-122, and miR-206 have been reported to regulate oocyte maturation and granulosa cell development [ 47 , 48 , 49 ]; they evidently regulate oocyte meiosis by targeting SMC3 , SGO1, and AURKA , respectively. SMC3 promotes oocyte apoptosis and affects the pathogenesis of polycystic ovary syndrome [ 50 , 51 ]. AURKA is a rate-limiting factor that promotes microtubule growth as oocytes resume meiosis [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

A Preliminary Study on the Characteristics of microRNAs in Ovarian Stroma and Follicles of Chuanzhong Black Goat during Estrus

Zou

Liu

et al. 2020

Genes

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microRNAs (miRNAs) play a significant role in ovarian follicular maturity, but miRNA expression patterns in ovarian stroma (OS), large follicles (LF), and small follicles (SF) have been rarely explored. We herein aimed to identify miRNAs, their target genes and signaling pathways, as well as their interaction networks in OS, LF, and SF of Chuanzhong black goats at the estrus phase using small RNA-sequencing. We found that the miRNA expression profiles of LF and SF were more similar than those of OS—32, 16, and 29 differentially expressed miRNAs were identified in OS vs. LF, OS vs. SF, and LF vs. SF, respectively. Analyses of functional enrichment and the miRNA-targeted gene interaction network suggested that miR-182 (SMC3), miR-122 (SGO1), and miR-206 (AURKA) were involved in ovarian organogenesis and hormone secretion by oocyte meiosis. Furthermore, miR-202-5p (EREG) and miR-485-3p (FLT3) were involved in follicular maturation through the MAPK signaling pathway, and miR-2404 (BMP7 and CDKN1C) played a key role in follicular development through the TGF-β signaling pathway and cell cycle; nevertheless, further research is warranted. To our knowledge, this is the first study to investigate miRNA expression patterns in OS, LF, and SF of Chuanzhong black goats during estrus. Our findings provide a theoretical basis to elucidate the role of miRNAs in follicular maturation. These key miRNAs might provide candidate biomarkers for the diagnosis of follicular maturation and will assist in developing new therapeutic targets for female goat infertility.

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“…The most exclusive function of DHEA is that it can be metabolized to potent androgens and oestrogens (31). Supplementation with DHEA appears to produce more precise results and cause fewer adverse side effects than supplementation with testosterone (32,33).…”

Section: Mechanism Of Dhea For Dormentioning

confidence: 99%

Advances in understanding the effect and mechanism of dehydroepiandrosterone on diminished ovarian reserve

Wang

Pan

Zhou

et al. 2023

DD&T

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dehydroepiandrosterone, diminished ovarian reserve, testosterone, in vitro fertilization and embryo transfer Diminished ovarian reserve (DOR) refers to the decline in fertility caused by the loss of normal ovarian function. DOR is associated with adverse reactions to ovarian stimulation during in vitro fertilization and embryo transfer (IVF-ET), increasing cycle cancellation rates and reducing pregnancy rates. Although it is well known that dehydroepiandrosterone (DHEA) can be used as a dietary supplement for age-related diseases, its potential has gradually been shown for many diseases. In this review, we focus on the effects of DHEA on DOR, briefly analysing its clinical benefits and limitations and describing the mechanism of function and the clinical trials conducted. Therefore, we summarize the mechanisms and indications of DHEA for DOR.

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The effect of DHEA on apoptosis and cohesin levels in oocytes in aged mice

Cited by 10 publications

References 64 publications

Metabolic Mechanisms and Potential Therapeutic Targets for Prevention of Ovarian Aging: Data from Up-to-Date Experimental Studies

Metabolic Mechanisms and Potential Therapeutic Targets for Prevention of Ovarian Aging: Data from Up-to-Date Experimental Studies

A Preliminary Study on the Characteristics of microRNAs in Ovarian Stroma and Follicles of Chuanzhong Black Goat during Estrus

Advances in understanding the effect and mechanism of dehydroepiandrosterone on diminished ovarian reserve

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