1983
DOI: 10.2337/diab.32.2.s56
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The Effect of Diabetes on Blood Flow Properties

Abstract: Blood flow is a complex process combining fluid shearing in both plasma and the interior of red blood cells with elastic deformation of blood's solid elements. The red cell membrane is the major solid in blood, but platelets and white cells contribute solid behavior as well. Changes in blood's flow properties are often hidden by blood's ability to change its pattern of response. Capillary viscometry can be used to examine serum, plasma, and hemoglobin solutions directly, but rotational viscometry, where regula… Show more

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Cited by 87 publications
(28 citation statements)
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“…Increased blood viscosity at high shear rate, mainly dependent on plasma hyper®brinogenaemia, may increase the risk for blood¯ow disturbances in large arteries, also modifying circulation and thixotropy in microvascular regions. 25,26 Moreover the alteration of high shear rate blood viscosity may re¯ect a disorder of the normal erythrocyte deformability that was found to be very reduced in central obesity. 10,12 The coexistence of plasma hyperviscosity, reduced red cell deformability and increased erythrocyte aggregation (derived from the high values of blood viscosity at 1/200 ratio) 38 is more relevant in patients with central obesity, characterizing a deep rheological derangement in these subjects and an incipient risk of macrovascular and microvascular complications.…”
Section: Discussionmentioning
confidence: 99%
“…Increased blood viscosity at high shear rate, mainly dependent on plasma hyper®brinogenaemia, may increase the risk for blood¯ow disturbances in large arteries, also modifying circulation and thixotropy in microvascular regions. 25,26 Moreover the alteration of high shear rate blood viscosity may re¯ect a disorder of the normal erythrocyte deformability that was found to be very reduced in central obesity. 10,12 The coexistence of plasma hyperviscosity, reduced red cell deformability and increased erythrocyte aggregation (derived from the high values of blood viscosity at 1/200 ratio) 38 is more relevant in patients with central obesity, characterizing a deep rheological derangement in these subjects and an incipient risk of macrovascular and microvascular complications.…”
Section: Discussionmentioning
confidence: 99%
“…Microangiopathy is characterized by capillary basement membrane thickening and endothelial cell proliferation, which occurs in most tissues of diabetic patients and animals (Williamson & Kilo, 1983). Alterations in haemorheology (McMillan, 1983) and endothelial function (Stout, 1987) have been implicated in the aetiology of diabetes-related microvascular changes but the cause may well be multifactorial. There is evidence to suggest that, with the possible exception of the kidney where early increases in prostaglandin production may mediate early increases in renal blood flow (Craven & De Rubertis, 1989), the production of the vasodilator and anti-platelet agent, prostacyclin, is reduced in experimental and clinical diabetes (Silberbauer et al, 1979;Rosenblum & Hirsh, 1984;Carreras et al, 1980).…”
Section: Introductionmentioning
confidence: 99%
“…With improvement of control, the erythrocyte survival increased [21]. The shortened half-life of erythrocytes may be caused by reduced erythrocyte deformability [22], increased serum viscosity [23] and increased blood viscosity described in decompensated diabetes [24].…”
Section: Discussionmentioning
confidence: 99%