The effect of diabetes with pharmacotherapy for breast cancer on care resource use

Abstract

This study showed that diabetes itself is a risk factor for greater care resource use after controlling for confounding factors. Pharmacotherapy for breast cancer may influence poor glycemic control, thus leading to greater care resource use. Early detection and careful monitoring of diabetes are essential in malignancy to eliminate this burden on the health care system.

Influence of Diabetes Mellitus on Oncological Outcomes for Patients Living With Cancer

“…Of the 45 articles, 22 had sufficient reporting for inclusion in the meta-analysis. 19 - 40 Studies that met inclusion criteria but were not included in the meta-analysis were excluded due to not having ranked outcome or not comparing outcomes between patients with diabetes to those without diabetes (eg, the study included comparisons within the diabetes group only). The DM- and oncology-related health outcomes for persons living with cancer were grouped as (1) health care service utilization; (2) DM-related clinical complications, specifically, infection, cardiovascular, neurological, gastrointestinal, and hepatic/renal; and (3) other.…”

“…All included studies were conducted in an acute care setting (n = 22, 100.0%). 19 - 40 The majority of the studies were conducted in the United States (n = 8, 36.4%), 19 - 26 China (n = 3, 13.6%), 27 - 29 Italy (n = 3, 13.6%), 30 - 32 and the Netherlands (n = 2, 9.1%). 33 , 34 Japan, Spain, Turkey, Taiwan, and Germany each contributed one study, respectively.…”

“… 33 , 34 Japan, Spain, Turkey, Taiwan, and Germany each contributed one study, respectively. 35 - 39 One study included patient data from multiple international locations, including the United States, Canada, and Brazil. 40 The common study design employed was observational (n = 21, 95.5%), 19 - 39 with the majority of these (n = 17) 19 , 21 - 33 , 37 - 39 being retrospective.…”

“… 35 - 39 One study included patient data from multiple international locations, including the United States, Canada, and Brazil. 40 The common study design employed was observational (n = 21, 95.5%), 19 - 39 with the majority of these (n = 17) 19 , 21 - 33 , 37 - 39 being retrospective. One included study was an RCT.…”

“…The data on infection complications were reported by 10 studies with a total number of 7820 persons with both cancer and DM and 33 005 persons only with cancer. 20,21,23,24,[27][28][29][30]36,39 The evidence from the pooled analysis showed that compared to persons only with cancer, those with cancer and DM were 1.33 times more likely to have infectious complications (RR = 1.33; 95% CI, 1.11-1.60; Figure 4).…”