The Effect of Dialysate Composition on Systemic Hemodynamics

Palmer, Biff F.

doi:10.1111/j.1525-139x.1992.tb00457.x

Cited by 15 publications

(4 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These concentrations are higher than in normal serum. Both sodium and chloride concentrations in Dianeal (Baxter Healthcare Corporation, Deerfield, IL, USA) PD fluid are slightly below those of serum (36). Therefore, the sodium or chloride content of PD fluid is not likely to be primarily responsible for the PD fluid potentiation of fibrocyte differentiation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Peritoneal Dialysis Fluid and Some of its Components Potentiate Fibrocyte Differentiation

et al. 2016

View full text Add to dashboard Cite

Long-term peritoneal dialysis (PD) often results in the development of peritoneal fibrosis. In many other fibrosing diseases, monocytes enter the fibrotic lesion and differentiate into fibro-blast-like cells called fibrocytes. We find that peritoneal tissue from short-term PD patients contains few fibrocytes, while fibrocytes are readily observed in the peritoneal membrane of long-term PD patients. The PD fluid Dianeal (Baxter Healthcare Corporation, Deerfield, IL, USA) contains dextrose, a number of electrolytes including sodium chloride, and sodium lactate. We find that PD fluid potentiates human fibrocyte differentiation in vitro and implicates sodium lactate in this potentiation. The plasma protein serum amyloid P (SAP) inhibits fibrocyte differentiation. Peritoneal dialysis fluid and sodium chloride decrease the ability of human SAP to inhibit human fibrocyte differentiation in vitro. Together, these results suggest that PD fluid contributes to the development of peritoneal fibrosis by potentiating fibrocyte differentiation.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Thus, the inhibition of fibrocyte differentiation at high sodium lactate concentrations is likely due to sodium, not lactate. Lactate diffuses into the blood over the course of a dialysis exchange, following which it is converted to bicarbonate in the liver (36). The serum lactate concentration is ∼1 – 2 mM (37).…”

Section: Discussionmentioning

confidence: 99%

Peritoneal Dialysis Fluid and Some of its Components Potentiate Fibrocyte Differentiation

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The decline in extracellular (and intravascular) osmolality is associated with an intracellular shift of fluid. This fluid shift, which occurs in the setting of ongoing ultrafiltration, further contributes to hypotension through delayed plasma refilling (1,2,4). Low sodium dialysate (~1 3 6 mEqL), now rarely used, similarly causes hypotension through a reduction in extracellular osmolality and a decrease in the plasma refilling rate (1,2,4).…”

Section: Pathophysiology O F Lntradialytic Hypotensionmentioning

confidence: 99%

“…This fluid shift, which occurs in the setting of ongoing ultrafiltration, further contributes to hypotension through delayed plasma refilling (1,2,4). Low sodium dialysate (~1 3 6 mEqL), now rarely used, similarly causes hypotension through a reduction in extracellular osmolality and a decrease in the plasma refilling rate (1,2,4). A slight increase in core body temperature, which occurs for unclear reasons in patients during dialysis, may also contribute to intradialytic hypotension through a vasodilatory effect (1).…”

Section: Pathophysiology O F Lntradialytic Hypotensionmentioning

confidence: 99%

Midodrine

Perazella

1997

Seminars in Dialysis

View full text Add to dashboard Cite

23. lankovic J. Gilden JL, Hiner BC. Kaufmann H, Brown DC. Coghlan CH, Rubin M, Fouad-Tanzi FM: Neurogenic orthostatic hypounsion: A doubleblind, placebo-contmlled study with midodrine. Am J Med 95:38-48. 1993 24. Flynn JJ. Mitchell MC. Caruso FS, McElligott MA: Midodrine treatment for patients with hemodialysis hypotension. Clin Nephrol45:261-267. 1996 25. BIowey DL, Balfe JW. Gupta I. Gajaria MM. Koren G: Midodrine efficacy and pharmacokinetics in a patient with recurrent intradidytic hypotension.

show abstract

Acute Renal Failure

Kjellstrand¹,

Teehan²

Replacement of Renal Function by Dialysis

View full text Add to dashboard Cite

Incidence of acute renal failure, need for dialysis Causes of acute renal failure, general workup of patients Pathogenesis, pathophysiology, and differential diagnosis of acute renal failure Experimental studies Clinical studies Differential diagnosis Avoiding dialysis-etiologic treatment Cause of death and prognostic factors Cause of death Prognostic factors Demographic factors Co-morbid condition Basic underlying disease Type and degree of renal failure Signs of infections Complicating disorders. 'Organ system failure' Type and quantity of dialysis Multifactorial prognostic formulae Summary of prognostic factors Treatment early: resuscitation Fluid overload Hyperkalemia Treatment late: conservative Avoiding infections Re-operation and surgical complications Nutrition, hyperalimentation Bleeding Other metabolic problems Use of drugs Treatment with acute dialysis Overview of methods Comparison of dialysis methods; intermittent and continuous hemodialysis; peritoneal dialysis 821 822 822 823 823 824 824 826 828 828 828 828 828 828 828 829 829 829 829 829 829 830 830 832 834 834 834 834 835 835 835 835 Acute dialysis Start, frequency and speed of dialysis Vascular access Anticoagulation Dialyzers and dialysis machines, biocompatibility Dialysis solutions-intermittent hemodialysis Sodium Potassium Calcium Magnesium B ica rbona tel acetate Dextrose Phosphorus Chloride Dialysis solutions-continuous hemodialysis Complications of hemodialysis and their treatment Blood pressure problems Cardiac arrhythmias Electrolyte abnormalities Disequilibrium Cell destruction Hypoxemia Peritoneal dialysis Access to the peritoneum Choice of fluids and additives Complications of peritoneal dialysis Technical problems Metabolic complications Cardiovascular and pulmonary complications Infectious complications Improving survival Recovery of renal function: need for continuous dialysis

show abstract

The Effect of Dialysate Composition on Systemic Hemodynamics

Cited by 15 publications

References 46 publications

Peritoneal Dialysis Fluid and Some of its Components Potentiate Fibrocyte Differentiation

Peritoneal Dialysis Fluid and Some of its Components Potentiate Fibrocyte Differentiation

Midodrine

Acute Renal Failure

Contact Info

Product

Resources

About