The Effect of Diclofenac Sodium on Callus Formation in White Male Rat (Rattus norvegicus) Cruris Fracture Healing

Wibowo, Herry; Widiyanti, Prihartini

doi:10.20473/fmi.v58i2.25212

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…The bone healing process consists of four stages: inflammation, soft callus formation, complex callus formation, and bone remodeling. 47 Bony compartments can achieve optimal healing in several ways after getting injured or in the case of fracture, namely intramembranous and endochondral ossification. Intramembranous ossification is one of the healing processes that mainly requires the direct differentiation of mesenchymal precursor cells (MPC) to osteoblasts without going through the cartilaginous phase -which is not the case of endochondral ossification, which undergoes cartilaginous phase (the proliferation of MPCs to chondrocyte first).…”

Section: Sternal Healingmentioning

confidence: 99%

The outcome of sternum healing among diabetic patients undergoing open heart surgery: a literature review

2022

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Background: As part of the surgery, sternotomy is a common technique to expose the underlying organs, allowing surgeons to explore the targeted organ. Despite the benefits offered, it has several considerable complications; one of them is wound healing defect. The impairment of sternal wound healing after sternotomy could be superficial and/or deep. This condition is influenced by many factors, including diabetes mellitus, obesity, and other comorbidities. These anomalies will affect the normal healing process of the bone and other connective tissue, particularly after a major invasive event, such as in sternotomy. This study aimed to review the outcome of sternum healing among diabetics that underwent heart surgery with a sternotomy approach. Methods: Works of literature reviewed in this study were obtained from Pubmed and Google Scholar databases starting from 1992 until April 2022. The keywords used were ‘sternal wound healing’, ‘cardiac surgery’, and ‘diabetes mellitus’. An advanced search based on the exact phrases was conducted on Google Scholar. Gathered kinds of literature were then selected based on relevancy. Results: The majority of articles reviewed were observational, and most of them had CABG as a part of open heart surgery, followed by valvular and aortic surgeries and others. The incidence of impaired sternal healing and other complications (superficial and/or deep) was more commonly seen among patients with diabetes. Most studies also reported a significant correlation between DM and the incidence of impaired sternal healing, suggesting that DM was a significant predictor of it. Conclusion: Diabetes mellitus is a medical condition that must be taken into account among the candidates for open heart surgery, particularly if it is poorly controlled. The Hyperglycaemic state experienced by the patients will lead to multiorgan damage and immunological dysfunction that could affect the healing process of the sternum.

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Section: Sternal Healingmentioning

confidence: 99%

The outcome of sternum healing among diabetic patients undergoing open heart surgery: a literature review

2022

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NSAIDs effect on bone healing

Muhammad Zeeshan

2024

Innovation in Osteogenesis Research [Working Title]

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The extensive use of non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of severe pain associated with bone fractures raises concerns regarding their impact on fracture healing. While NSAIDs are favored for their anti-inflammatory properties, long-term administration has been associated with adverse effects on fracture healing. Despite the recognized risks, conflicting information exists regarding the effects of NSAIDs on fracture healing. Fracture healing is a complex process involving mechanisms of repair, including direct and indirect bone healing pathways. The inflammatory phase plays a crucial role in initiating the healing, with immune cells secreting cytokines and growth factors essential for healing. Prostaglandins, synthesized by COX enzymes, are key mediators, exerting stimulatory effects on bone formation and resorption. However, NSAIDs inhibit prostaglandin synthesis by blocking COX activity, disrupting the fracture-healing process. NSAIDs also have an inhibitory effect on the differentiation of chondrocytes into mature hypertrophied chondrocytes, crucial for endochondral ossification. Collagen X, expressed by hypertrophied chondrocytes, serves as a vital marker of fracture healing and has been implicated in the successful union of fractures. A comprehensive understanding of the interplay between NSAIDs, prostaglandins, and fracture healing mechanisms is essential for optimizing treatment strategies and minimizing adverse outcomes in patients with bone fractures.

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The Effect of Diclofenac Sodium on Callus Formation in White Male Rat (Rattus norvegicus) Cruris Fracture Healing

Cited by 2 publications

References 17 publications

The outcome of sternum healing among diabetic patients undergoing open heart surgery: a literature review

The outcome of sternum healing among diabetic patients undergoing open heart surgery: a literature review

NSAIDs effect on bone healing

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