The Effect of Dietary Antioxidant Supplementation in Patients with Glaucoma

Himori, Noriko; Yanagimachi, Maki Inoue; Omodaka, Kazuko; Shiga, Yukihiro; Tsuda, S.; Kunikata, Hiroshi; Nakazawa, Toru

doi:10.2147/opth.s314288

Cited by 22 publications

(17 citation statements)

References 29 publications

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“…The treatment with LG saves a significant portion of these RGCs, and this is particularly relevant in peripheral retina, where LG treatment results in virtually complete rescue of the RGCs. According to these observations, both preclinical and clinical studies have reported RGC loss and PERG defects in glaucomatous retinas, which were protected by antioxidant treatments obtained with nutritional supplements ( Parisi et al, 2014 ; Cammalleri et al, 2020 ; Himori et al, 2021 ; Oddone et al, 2021 ).…”

Section: Discussionmentioning

confidence: 93%

The Potential of Lisosan G as a Possible Treatment for Glaucoma

et al. 2021

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Lisosan G (LG), a fermented powder obtained from whole grains, is a nutritional supplement containing a variety of metabolites with documented antioxidant properties. We have recently demonstrated that orally administered LG protects diabetic rodent retinas from oxidative stress, inflammation, apoptosis, blood-retinal barrier disruption, and functional damage. Here, we investigated whether LG may exert protective effects in a model of glaucoma and measured the amounts of selected LG components that reach the retina after oral LG administration. Six-month-old DBA/2J mice were given an aqueous LG solution in place of drinking water for 2 mo. During the 2 mo of treatment with LG, the intraocular pressure (IOP) was monitored and the retinal ganglion cell (RGC) functional activity was recorded with pattern-electroretinography (PERG). At the end of the 2-mo period, the expression of oxidative stress and inflammatory markers was measured with qPCR, and RGC survival or macroglial activation were assessed with immunofluorescence. Alternatively, LG was administered by gavage and the concentrations of four of the main LG components (nicotinamide, gallic acid, 4-hydroxybenzoic acid, and quercetin) were measured in the retinas in the following 24 h using mass spectrometry. LG treatment in DBA/2J mice did not influence IOP, but it affected RGC function since PERG amplitude was increased and PERG latency was decreased with respect to untreated DBA/2J mice. This improvement of RGC function was concomitant with a significant decrease of both oxidative stress and inflammation marker expression, of RGC loss, and of macroglial activation. All four LG metabolites were found in the retina, although with different proportions with respect to the amount in the dose of administered LG, and with different temporal profiles in the 24 h following administration. These findings are consistent with neuroenhancing and neuroprotective effects of LG in glaucoma that are likely to derive from its powerful antioxidant properties. The co-occurrence of different metabolites in LG may provide an added value to their beneficial effects and indicate LG as a basis for the potential treatment of a variety of retinal pathologies.

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Section: Discussionmentioning

confidence: 93%

The Potential of Lisosan G as a Possible Treatment for Glaucoma

et al. 2021

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“… 53 Recently, we performed a clinical study that revealed that an antioxidant supplement including hesperidin, crocetin, and Tamarindus indica improved antioxidant levels in the blood of glaucoma patients with high oxidative stress. 54 Therefore, dietary supplementation with plant containing hesperidin, crocetin, or Tamarindus indica has potential as a new therapeutic approach to protect against retinal damage associated with excitotoxic injury in diseases such as glaucoma and diabetic retinopathy.…”

Section: Discussionmentioning

confidence: 99%

A Plant-Derived Antioxidant Supplement Prevents the Loss of Retinal Ganglion Cells in the Retinas of NMDA-Injured Mice

Maekawa¹,

Sato²,

Kokubun³

et al. 2022

OPTH

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Purpose To investigate the effect of plant-derived antioxidant compounds, identified with primary culture screening, on retinal ganglion cell (RGC) survival in mice under excitotoxic conditions. Additionally, to determine the effect of these compounds on the involvement of calpain inactivation. Materials and Methods Plant-derived antioxidant compounds including hesperidin, crocetin, and Tamarindus indica were administrated orally to C57BL/6J mice. The levels of lipid oxidation and calpain activation were assessed with a TBARS assay and western blotting. RGC survival was evaluated with a TUNEL assay and RBPMS immunostaining after intravitreal injection of NMDA. Results Plant-derived antioxidant compounds significantly ameliorated the increase in the level of MDA in the retinas after NMDA injury. Cleaved α-fodrin fragments were detected in the NMDA-injured retinas, and these fragments were significantly lower in mice that received the plant-derived antioxidant compounds. The plant-derived antioxidants also ameliorated increases in TUNEL-positive cells and RGC death after NMDA injection. Conclusion These results indicate that oral administration of plant-derived antioxidant compounds such as hesperidin, crocetin, and Tamarindus indica suppressed RGC death. This oral supplementation decreased lipid oxidation and excessive calpain activation in NMDA-injured retinas. Thus, our newly developed antioxidant supplement has a potential role in neuroprotective treatment for retinal diseases, such as glaucoma.

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“…Hesperidin is a flavanone commonly found in citrus fruits such as oranges, tangerines, lemons and grapefruits, known for its anti-inflammatory, antioxidant and anticarcinogenic properties [221]. The antioxidant profile of a novel supplement containing hesperidin, and two other food-derived antioxidants, i.e., crocetin and Tamarindus indica (tamarind), was assessed in a prospective, single-arm design trial involving 30 NTG patients receiving the supplements for 8 weeks [222]. In patients with relatively high oxidative stress, the supplement significantly reduced the urinary 8-hydroxy-2 -deoxyguanosine (8-OHdG; a marker of oxidative DNA damage) level, and the biological antioxidant potential was also significantly elevated [222].…”

Section: Hesperidinmentioning

confidence: 99%

Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

et al. 2022

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Glaucoma is one of the leading causes of irreversible blindness. It is generally caused by increased intraocular pressure, which results in damage of the optic nerve and retinal ganglion cells, ultimately leading to visual field dysfunction. However, even with the use of intraocular pressure-lowering eye drops, the disease still progresses in some patients. In addition to mechanical and vascular dysfunctions of the eye, oxidative stress, neuroinflammation and excitotoxicity have also been implicated in the pathogenesis of glaucoma. Hence, the use of natural products with antioxidant and anti-inflammatory properties may represent an alternative approach for glaucoma treatment. The present review highlights recent preclinical and clinical studies on various natural products shown to possess neuroprotective properties for retinal ganglion cells, which thereby may be effective in the treatment of glaucoma. Intraocular pressure can be reduced by baicalein, forskolin, marijuana, ginsenoside, resveratrol and hesperidin. Alternatively, Ginkgo biloba, Lycium barbarum, Diospyros kaki, Tripterygium wilfordii, saffron, curcumin, caffeine, anthocyanin, coenzyme Q10 and vitamins B3 and D have shown neuroprotective effects on retinal ganglion cells via various mechanisms, especially antioxidant, anti-inflammatory and anti-apoptosis mechanisms. Extensive studies are still required in the future to ensure natural products’ efficacy and safety to serve as an alternative therapy for glaucoma.

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The Effect of Dietary Antioxidant Supplementation in Patients with Glaucoma

Cited by 22 publications

References 29 publications

The Potential of Lisosan G as a Possible Treatment for Glaucoma

The Potential of Lisosan G as a Possible Treatment for Glaucoma

A Plant-Derived Antioxidant Supplement Prevents the Loss of Retinal Ganglion Cells in the Retinas of NMDA-Injured Mice

Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

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