The effect of dietary approaches to stop hypertension (DASH) on serum inflammatory markers: A systematic review and meta-analysis of randomized trials

Soltani, Sepideh; Chitsazi, Maryam J.; Salehi‐Abargouei, Amin

doi:10.1016/j.clnu.2017.02.018

Cited by 151 publications

(114 citation statements)

References 45 publications

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“…In view of our knowledge, this is the first study assessing the effect of the DASH diet on plasma CXCL4 concentration among patients with atherosclerotic plaque in coronary arteries. In the previous studies, a beneficial effect of the DASH diet on high sensitivity C-reactive protein concentration (hs-CRP) has been already observed [13,14]. Moreover, the study by Phillips et al indicated correlation between high DASH score diet and decreased concentrations of IL-6, TNF-a, as well as increased adiponectin concentrations [15].…”

Section: Discussionmentioning

confidence: 93%

DASH diet decreases CXCL4 plasma concentration in patients diagnosed with coronary atherosclerotic lesions

Makarewicz‐Wujec

Henzel

Kruk

et al. 2020

Nutrition, Metabolism and Cardiovascular Diseases

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Background and aims: Aim of this study involved assessment of the intensive intervention concerning lifestyle based on the DASH diet model on plasma concentration of CXCL4 chemokine among patients with coronary atherosclerosis. Methods and results: The Dietary Intervention to Stop Coronary Atherosclerosis in Computed Tomography Study randomized patients with stable CAD to an interventional group (n Z 41), where DASH diet was implemented and the control group (n Z 40) without dietary intervention.Dietary counselling was provided to DASH group during all 6 control visits within 6 months of observation. During the study, body weight and body composition were controlled using the bioimpedance method. CXCL4 concentration was determined with the use of ELISA test.Within the DASH group, a significant decrease in body weight, a decrease in high sensitivity Creactive protein concentration (À0.32 AE 2.8 mg/l; p < 0.05), as well as a decrease in CXCL4 concentration (À3.35 AE 3.4 ng/ml; p < 0.0001) were observed. Occurring changes were not statistically significant within the control group. Conclusions: DASH diet lessens CXCL4 concentration among patients with a stable CAD, however, further research is necessary in order to confirm aforementioned results and evaluate the impact on atherosclerotic plaque. This trial was registered at: www.clinicaltrials.gov as NCT02571803.

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Section: Discussionmentioning

confidence: 93%

DASH diet decreases CXCL4 plasma concentration in patients diagnosed with coronary atherosclerotic lesions

Makarewicz‐Wujec

Henzel

Kruk

et al. 2020

Nutrition, Metabolism and Cardiovascular Diseases

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“…On the other hand, the diet is low in harmful compounds found in processed meats, sugar-sweetened beverages, and salt, which are associated with inflammation, oxidative stress, hypertension, insulin resistance, and carcinogenesis [61]. The previous investigations have also provided evidence about the beneficial effects of the DASH diet on insulin resistance [19], hypertension [16], hyperlipidemia [53], inflammation [20], and oxidative stress [53], which are shown to be associated with CVD, stroke, and cancers.…”

Section: Discussionmentioning

confidence: 99%

“…The previous systematic reviews have shown that the better compliance with the DASH dietary pattern could reduce systolic and diastolic blood pressure, total cholesterol and low-density lipoprotein (LDL) [16,17], body weight and fat [18]; and also improve glycemic control [19], and serum inflammatory markers [20]; thus, it might significantly protect against CVD, stroke, diabetes, and cancers, which are associated with a lower life expectancy rate [21]. Prospective studies on the association between the DASH diet and the mortality rate have shown some incompatible findings [22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Adherence to the dietary approaches to stop hypertension (DASH) diet in relation to all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective cohort studies

Soltani

Arablou

Jayedi

et al. 2020

Nutr J

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109

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Background: Although previous investigations have proposed an association between Dietary Approaches to Stop Hypertension (DASH)-style diet and lower mortality from chronic diseases, the exposure-response relationship is not clear. The present systematic review and meta-analysis aimed to explore the linear and non-linear doseresponse association between adherence to the DASH diet and all-cause and cause-specific mortality.Methods: Database search was performed in PubMed, Scopus, and EMBASE for prospective cohort studies investigating the association between adherence to the Dietary Approaches to Stop Hypertension (DASH) diet and risk of mortality. Summary hazard ratios (HRs) and 95% confidence intervals (CI) were estimated with the use of a random-effects model for the linear and nonlinear relationships. The two-stage hierarchical regression model was applied to test the potential non-linear dose-response associations. Results: The inclusion criteria were met by 17 studies (13 publications). The scores reported for adherence to the DASH diet in different studies were converted to a conventional scoring method in which the adherence score might range between 8 to 40. The linear analysis revealed that summary HRs were 0.95 (95% CI: 0.94-0.96, I 2 = 91.6%, n = 14) for all-cause, 0.96 (95% CI: 0.95-0.98, I 2 = 82.4%, n = 12) for CVD, 0.97 (95% CI: 0.96-0.98, I 2 = 0.00%, n = 2) for stroke, and 0.97 (95% CI: 0.95-0.98, I 2 = 63.7%, n = 12) for cancer mortality per each 5-point increment of adherence to the DASH diet. There was also evidence of non-linear associations between the DASH diet and allcause and cause-specific mortality as the associations became even more evident when the adherence scores were more than 20 points (P < 0.005).Conclusion: Even the modest adherence to the DASH diet is associated with a lower risk of all-cause and causespecific mortality. The higher adherence to the diet also strengthens the risk-reducing association.(Continued on next page)

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“…Based on these results, the DASH dietary pattern most likely exerts its beneficial effects through a combination of all these dietary factors. The fruits, vegetables, and other food items emphasized by the DASH diet contain numerous flavonoids and antioxidants, which can help to significantly reduce biomarkers of oxidative stress and inflammation [40,41], improve endothelial function, and thereby decrease BP levels [42]. However, the mechanisms through which the DASH diet acts on metabolic health are not fully understood and should be investigated in greater depth.…”

Section: Discussionmentioning

confidence: 99%

Stricter Adherence to Dietary Approaches to Stop Hypertension (DASH) and Its Association with Lower Blood Pressure, Visceral Fat, and Waist Circumference in University Students

et al. 2020

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How diet affects blood pressure (BP) in young adults has not been studied in sufficient depth. For this purpose, we analyzed adherence to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern and BP in Spanish university students. The sample population of our cross-sectional study consisted of 244 subjects (18-31 years old), who were in good health. Measurements were taken of their systolic and diastolic BP. A food frequency questionnaire and 72 h food record were used to assess their dietary intake in the previous year. The resulting DASH score was based on foodstuffs that were emphasized or minimized in the DASH diet. Analysis of covariance adjusted for potential confounding factors showed that the mean values for systolic BP, visceral fat rating, and waist circumference (WC) of the subjects in the upper third of the DASH score were significantly lower than those of the subjects in the lower third (for systolic BP: mean difference −4.36 mmHg, p = 0.004; for visceral fat rating: mean difference −0.4, p = 0.024; for waist circumference: mean difference −3.2, p = 0.019). Stricter adherence to the DASH dietary pattern led to a lower BP, visceral fat rating, and WC values in these university students. Nevertheless, further prospective studies are needed to confirm these results.

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The effect of dietary approaches to stop hypertension (DASH) on serum inflammatory markers: A systematic review and meta-analysis of randomized trials

Cited by 151 publications

References 45 publications

DASH diet decreases CXCL4 plasma concentration in patients diagnosed with coronary atherosclerotic lesions

DASH diet decreases CXCL4 plasma concentration in patients diagnosed with coronary atherosclerotic lesions

Adherence to the dietary approaches to stop hypertension (DASH) diet in relation to all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective cohort studies

Stricter Adherence to Dietary Approaches to Stop Hypertension (DASH) and Its Association with Lower Blood Pressure, Visceral Fat, and Waist Circumference in University Students

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