The effect of dietary .BETA.-sitosterol and .BETA.-sitostanol on the metabolism of cholesterol in rats.

Ikeda, Ikuo; Morioka, Hidekazu; Sugano, Michihiro

doi:10.1271/bbb1961.43.1927

Cited by 17 publications

(6 citation statements)

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“…There remains controversy, however, over the relative cholesterol-reducing efficacy of plant sterols versus stanols. A recent finding that esters of unsaturated ␤ -sitosterol and campesterol produce the same cholesterol-lowering efficacy as esters of sitostanol and campestanol, when added to margarines (10), is somewhat inconsistent with previous animal data (4,5,7,11). This earlier data from animals suggest that efficacy of cholesterol-lowering action increases with the extent of hydrogenation of the phytosterol mixture.…”

mentioning

confidence: 88%

“…Subjects also underwent complete physical examinations and urinalyses at the beginning and end of each dietary treatment. Ninety-six hours before the end of the trial on day 18, subjects were intravenously (iv) injected with 15 mg D 7 -cholesterol and simultaneously ingested 90 mg [3,[4][5][6][7][8][9][10][11][12][13] C]-cholesterol. Five subjects during the first phase did not receive D 7 -cholesterol.…”

Section: Protocol and Dietmentioning

confidence: 99%

“…Saturation of phytosterols at the 5-alpha position form compounds including sitostanol and campestanol. For several decades it has been appreciated that consumption of plant sterols and stanols led to favorable shifts in circulat-ing lipid levels (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). In general terms, plant sterol and stanol consumption in human subjects under a range of experimental circumstances reduces plasma total and low density lipoprotein cholesterol (LDL-C) concentrations within the range of 0.5-26% and 2-33%, respectively (ref.…”

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confidence: 99%

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Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol esters

Jones

Raeini−Sarjaz

Ntanios

et al. 2000

Journal of Lipid Research

324

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It has been suggested that phytosterol and phytostanol esters possess similar cholesterol-lowering properties, however, whether mechanisms responsible are identical has not been addressed. To address this question, cholesterol plasma levels, absorption, biosynthesis, and turnover were measured in 15 hypercholesterolemic subjects consuming prepared diets each over 21 d using a crossover design. Diets contained either i ) margarine (M), ii ) margarine with phytosterol esters (MSE) (1.84 g/d), or iii ) margarine with phytostanol esters (MSA) (1.84 g/d). Cholesterol absorption was measured using the ratio of [ 13 C]cholesterol oral :D 7 -cholesterol IV ; biosynthesis using D incorporation from D 2 O and turnover by D 7 -cholesterol IV decay rates. Plasma total cholesterol level at d 21/22 was lower ( P Ͻ 0.05) for MSE (13.4%) but not MSA (10.2%) versus M (6.0%) diets. Plasma low density lipoprotein-cholesterol (LDL-C) mean reductions at d 21/22 were larger ( P Ͻ 0.05) for MSE (12.9%) and MSA (7.9%) compared with M (3.9%). Plasma TG and high density lipoprotein-cholesterol (HDL-C) levels did not differ across diets. Cholesterol absorption was reduced ( P Ͻ 0.05) 36.2 and 25.9% at d 21 for MSE and MSA versus M, while cholesterol biosynthesis was reciprocally increased ( P Ͻ 0.05) 53.3 and 37.8% for MSE and MSA versus M, respectively. Cholesterol turnover was not influenced by diet. These data indicate that plant sterol and stanol esters differentially lower circulating total and LDL cholesterol levels by suppression of cholesterol absorption in hypercholesterolemic subjects. -

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mentioning

confidence: 88%

Section: Protocol and Dietmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol esters

Jones

Raeini−Sarjaz

Ntanios

et al. 2000

Journal of Lipid Research

324

View full text Add to dashboard Cite

show abstract

“…A recent finding that esters of unsaturated ␤ -sitosterol and campesterol produce the same cholesterol-lowering efficacy as esters of sitostanol and campestanol, when added to margarines (10), is somewhat inconsistent with previous animal data (4,5,7,11). A recent finding that esters of unsaturated ␤ -sitosterol and campesterol produce the same cholesterol-lowering efficacy as esters of sitostanol and campestanol, when added to margarines (10), is somewhat inconsistent with previous animal data (4,5,7,11).…”

mentioning

confidence: 91%

Induction of speech arrest and counting errors with rapid‐rate transcranial magnetic stimulation

Pascual‐Leone

Gates²,

Dhuna³

1991

Neurology

463

203

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Six adult epileptic patients underwent rapid-rate transcranial magnetic stimulation (rTMS) at stimulation rates of up to 25 Hz with an 11-cm water-cooled round coil held flat on the scalp, centered over 15 different positions on each side of the scalp. The trains of stimuli were for 10 seconds while the patients counted aloud. rTMS centered over D5 or D7 induced reproducible speech arrest in all patients and counting errors in three when applied at lower intensities. There were no such speech disturbances by rTMS centered over the different positions on the right side. Intracarotid amobarbital test (IAT) demonstrated left hemispheric language dominance in all patients. Lateralization of speech arrest induced by rTMS correlated with the IAT results and may be helpful for noninvasive determination of hemispheric language dominance.

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“…in humans and animals (Sugano et al 1976;Ikeda et al 1979). Several prospective clinical trials have confirmed that lowering plasma lipid levels significantly reduces the death rate from coronary vascular and related diseases (Anonymous 1994(Anonymous , 1996Sacks et al 1995).…”

mentioning

confidence: 99%

Gender effects of tall oil versus soybean phytosterols as cholesterol-lowering agents in hamsters

Ntanios¹,

MacDougall²,

Jones³

1998

Can. J. Physiol. Pharmacol.

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To examine the effect of gender on the mechanisms of action of phytosterols extracted from tall oil (TO) and soybean (SB) on cholesterol and phytosterol metabolism, male and female hamsters were fed cholesterol-enriched diets containing 0.5 or 1% (w/w) TO or SB phytosterols for 90 days. Plasma lipoprotein cholesterol profile and tissue phytosterol and cholesterol biosynthesis levels were determined. Mean plasma total-cholesterol level in females fed 1% (w/w) SB was reduced (p<0.05) by 44%, while in males it was lowered (p<0.05) by 25% compared with their respective controls. Moreover, mean plasma total-cholesterol level was reduced (p<0.05) in male hamsters by -31% and female hamsters by -32% when fed 1% (w/w) TO. Cholesterol biosynthesis was higher (p<0.05) by twofold in groups fed TO at 0.5 and 1% (w/w) concentrations, compared with SB. Hamsters fed TO at 0.5 and 1% (w/w) levels also had higher (p<0.05) hepatic and enterocytic campesterol contents than SB-fed animals. These findings demonstrate gender differences in cholesterol metabolism in TO- and SB-fed hamsters. The results suggest that TO, conversely to SB phytosterol, is a more effective cholesterol-lowering agent in male, but not as much in female, hamsters, over a feeding period of 90 days.

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The effect of dietary .BETA.-sitosterol and .BETA.-sitostanol on the metabolism of cholesterol in rats.

Abstract: Effects of dietary ƒÀ-sitosterol (S) and ƒÀ-sitostanol (HS) on the metabolism and fate of labeled cholesterol intravenously injected were compared in rats fed diets high in cholesterol. Kinetic behavior of the decay curve for serum cholesterol in the HS supplemented (C+HS)

Cited by 17 publications

References 1 publication

Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol esters

Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol esters

Induction of speech arrest and counting errors with rapid‐rate transcranial magnetic stimulation

Gender effects of tall oil versus soybean phytosterols as cholesterol-lowering agents in hamsters

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