The effect of dietary fiber on human pancreatic enzyme activity in vitro

Dunaif, G. E.; Schneeman, Barbara O.

doi:10.1093/ajcn/34.6.1034

Cited by 171 publications

(80 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Certain high fibers may have antienzyme activity (50). Fiber has been shown to reduce pancreatic enzyme activity and decrease pancreatic enzyme secretion (54,55). Gut hormone effects.…”

Section: Physiologic Effects Of Fibermentioning

confidence: 99%

Dietary Fiber in Management of Diabetes

1988

View full text Add to dashboard Cite

Current evidence suggests that high-fiber diets, especially of the soluble variety, and soluble fiber supplements may offer some improvement in carbohydrate metabolism, lower total cholesterol and low-density lipoprotein (LDL) cholesterol, and have other beneficial effects in patients with non-insulindependent diabetes mellitus (NIDDM). Diets enriched with wheat bran and guar gum induce 10-20% reductions in serum cholesterol and LDL in both normoand hypercholesterolemic subjects and have the ability to blunt the hypertriglyceridemic effects of diets high in carbohydrate and low in fiber. In insulin-dependent diabetes mellitus (IDDM) the situation is less clear, but a decrement of the circadian glucose profile has been shown. Americans, in general, consume too little fiber. With the need to restrict fat and reduce protein, an increase in carbohydrates is mandatory. A practical goal would be to establish the present level of fiber intake (15-30 g/day) and to gradually increase it. An intake of up to 40 g of fiber per day or 25 g/1000 kcal of food intake appears beneficial; in many individuals on weight-reducing diets higher levels may be unacceptable because of gastrointestinal side effects. The level of maximum benefit has not been determined. Fiber supplementation appears beneficial only if given with a diet comprising approximately half of the calories as carbohydrate. Foods should be selected with moderate to high amounts of dietary fiber from a wide variety of choices to include both soluble and insoluble types of fiber. Insufficient data are available on the long-term safety of high-fiber supplements. People at risk for deficiencies, such as postmenopausal women, the

show abstract

“…Certain high fibers may have antienzyme activity (50). Fiber has been shown to reduce pancreatic enzyme activity and decrease pancreatic enzyme secretion (54,55). Gut hormone effects.…”

Section: Physiologic Effects Of Fibermentioning

confidence: 99%

Dietary Fiber in Management of Diabetes

1988

View full text Add to dashboard Cite

show abstract

“…Soluble ®bers increase the viscosity of the alimentary bolus, and hence lengthen the gastric emptying and intestinal transit times (Wood, 1990;Cameron-Smith et al, 1994;Johansen et al, 1996). In addition, the rate of starch digestion by pancreatic amylases is delayed by soluble ®bers in vitro, an effect which is related to the viscosity of the ®bers which may delay the interaction of the enzyme with its substrate (Dunaif & Schneeman, 1981;Hansen & Schulz, 1982;Dutta & Hlasko, 1985). These two mechanisms limit the postprandial rise in plasma glucose concentration by reducing the rate of carbohydrate absorption from the gastrointestinal tract.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of action of β-glucan in postprandial glucose metabolism in healthy men

et al. 2001

View full text Add to dashboard Cite

Objective: To assess whether b-glucan (which is fermented in the colon) lowers postprandial glucose concentrations through mechanisms distinct from a delayed carbohydrate absorption and inhibits de novo lipogenesis. Design: Administration of frequent small meals each hour over 9 h allows a rate of intestinal absorption to be reached which is independent of a delayed absorption. A group of 10 healthy men received either an isoenergetic diet containing 8.9 gaday b-glucan or without b-glucan for 3 days. On the third day, the diet was administered as fractioned meals ingested every hour for 9 h. Setting: Laboratory for human metabolic investigations. Subjects: Ten healthy male volunteers. Main outcome measures: Plasma glucose and insulin concentrations, glucose kinetics, glucose oxidation, de novo lipogenesis. Results: On the third day, plasma glucose and free fatty acid concentrations, carbohydrate and lipid oxidation, and energy expenditure were identical with b-glucan and cellulose. Plasma insulin concentrations were, however, 26% lower with b-glucan during the last 2 h of the 9 h meal ingestion. Glucose rate of appearance at steady state was 12% lower with b-glucan. This corresponded to a 21% reduction in the systemic appearance rate of exogenous carbohydrate with b-glucan, while endogenous glucose production was similar with both diets. De novo lipogenesis was similar with and without b-glucan. Conclusion: Administration of frequent meals with or without b-glucan results in similar carbohydrate and lipid metabolism. This suggests that the lowered postprandial glucose concentrations which are observed after ingestion of a single meal containing b-glucan are essentially due to a delayed and somewhat reduced carbohydrate absorption from the gut and do not result from the effects of fermentation products in the colon. Descriptors: glucose production; de novo lipogenesis; substrate oxidation

show abstract

“…Dosage of pectin to human beings failed to lower cholesterol ( 13 ). Inhibitory effect of pectin on pancreatic lipase was weaker than other dietary fibers such as alfalfa, oat bran, wheat bran and xylan ( 14 ). The binding of porcine pancreatic lipase or human bile lipids on pectin was weaker than wheat bran ( 15 ).…”

mentioning

confidence: 99%

Inhibitory Effect of Pectin from the Segment Membrane of Citrus Fruits on Lipase Activity

Edashige

Murakami

Tsujita

2008

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

Summary Segment membranes from 4 citrus species selected from 4 sections were treated with water to obtain polysaccharides containing pectin. The extracts, which inhibited pancreatic lipase activity in a concentration-dependent manner, were divided into high molecular weight fractions [molecular weight (M.W.) Ͼ 300,000], which inhibited the activity strongly, and low molecular weight fractions (M.W. Ͻ 300,000), which did not show such strong inhibition. The high molecular weight fractions were composed mainly of a characteristic sugar of pectin, namely, galacturonic acid. A galacturonic acid-rich fraction purified by anion exchange chromatography from a water extract also strongly inhibited the activity. The inhibitory activity of the high molecular weight fraction was much stronger than that of commercial citrus pectin. The results suggest that pectin from segment membranes of citrus fruits might be useful as a functional food, especially as a fat-reducing material.

show abstract

The effect of dietary fiber on human pancreatic enzyme activity in vitro

Cited by 171 publications

References 8 publications

Dietary Fiber in Management of Diabetes

Dietary Fiber in Management of Diabetes

Mechanisms of action of β-glucan in postprandial glucose metabolism in healthy men

Inhibitory Effect of Pectin from the Segment Membrane of Citrus Fruits on Lipase Activity

Contact Info

Product

Resources

About