The effect of dietary fish oil on survival after infection with Klebsiella pneumoniae or Streptococcus pneumoniae

Thors, Valtýr; Thorisdottir, Audur; Erlendsdóttir, Helga; Einarsson, Ingólfur; Guðmundsson, Sigurður; Gunnarsson, Eggert; Haraldsson, Ásgeir

doi:10.1080/00365540310018914

Cited by 8 publications

(3 citation statements)

References 15 publications

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“…In the present study, the group fed on Xaxseed oil for 4 weeks followed by infection with S. pneumoniae was not able to survive the infection. Our Wndings corroborate the observation made by Thors et al [16], who demonstrated the beneWcial eVect of dietary Wsh oil (10% w/w of the diet) on the survival of mice following induction of experimental pneumonia with Klebsiella pneumoniae, but not after infection with Streptococcus pneumoniae serotype 3 when supplemented for 6 weeks [16]. Interestingly, the group fed on Xaxseed oil for 9 weeks showed improved survival after infection with S. pneumoniae.…”

Section: Discussionsupporting

confidence: 93%

Long-term flaxseed oil supplementation diet protects BALB/c mice against Streptococcus pneumoniae infection

Saini

Harjai

Mohan

et al. 2009

Med Microbiol Immunol

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Intense host immune response to infection contributes significantly to the pathology of pneumococcal pneumonia. Therefore, the regulation of host immune response is critical for the successful outcome of pneumonia in such patients. The aim of the present study was to investigate the effect of n-3 PUFA, i.e. flaxseed oil supplementation for short (4 weeks) as well as long (9 weeks) term, on the course of S. pneumoniae D39 serotype 2 infection in mice. The efficacy of flaxseed oil supplementation was investigated in terms of survival of animals and production of various inflammatory molecules (malondialdehyde, myeloperoxidase, nitric oxide) in the lung homogenate of animals. This was correlated with bacteriological and histopathological parameters. The immunomodulation was studied in terms of cytokines in the lungs following infection with Streptococcus pneumoniae. Results suggest that long-term flaxseed supplementation protected the mice against bacterial colonization of lungs with Streptococcus pneumoniae with reduced histopathological involvement of lung tissue. Moderate pneumonia was observed in supplemented, infected mice compared to severe pneumonia seen in control mice. This was accompanied by decreased inflammatory markers (malondialdehyde, myeloperoxidase, nitric oxide) as the disease progressed. In addition, difference in the levels of pro-inflammatory (TNF-alpha and IL-1beta) and anti-inflammatory (IL-10) cytokines was observed in the flaxseed fed animals. On the contrary, short-term supplementation did not show such an effect on lung colonization.

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Section: Discussionsupporting

confidence: 93%

Long-term flaxseed oil supplementation diet protects BALB/c mice against Streptococcus pneumoniae infection

Saini

Harjai

Mohan

et al. 2009

Med Microbiol Immunol

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“…Despite this, several studies have reported that an excess intake of n-3 polyunsaturated fatty acids may cause undesirable effects in both humans and animals, because they are able to reduce host immune resistance against infectious microorganisms (1,11). Thus, numerous investigations have indicated that diets containing n-3 polyunsaturated fatty acids enhance susceptibility to infection by Listeria monocytogenes (8,13,23), Salmonella enterica serovar Typhimurium (7), Mycobacterium tuberculosis (21), or Pseudomonas aeruginosa (22), whereas other recent observations have reported that these diets increase immune resistance against Klebsiella pneumoniae (2,3,27), although these effects could not be demonstrated in infection with Streptococcus pneumoniae (27). Therefore, it is possible that the consequences derived from the reduction of immune resistance by n-3 polyunsaturated fatty acids may also depend on the type of microorganisms and their pathogenic mechanisms.…”

mentioning

confidence: 96%

Assessment of Interleukin-12, Gamma Interferon, and Tumor Necrosis Factor Alpha Secretion in Sera from Mice Fed with Dietary Lipids during Different Stages ofListeria monocytogenesInfection

Puertollano

Cruz-Chamorro

Puertollano

et al. 2005

Clin Vaccine Immunol

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Recent experimental observations have determined that long-chain n-3 polyunsaturated fatty acids suppress immune functions and are involved in the reduction of infectious disease resistance. BALB/c mice were fed for 4 weeks with one of four diets containing either olive oil (OO), fish oil (FO), hydrogenated coconut oil, or a low fat level. Interleukin-12p70 (IL-12p70), gamma interferon (IFN-␥), and tumor necrosis factor alpha (TNF-␣) production in the sera of mice fed these diets and challenged with Listeria monocytogenes were determined by enzyme-linked immunosorbent assay. In addition, bacterial counts from spleens of mice were carried out at 24, 72, or 96 h of infection. Here, we quantified an initial diminution of production of both IL-12p70 and IFN-␥, which appear to play an important role in the reduction of host resistance to L. monocytogenes infection. In addition, an efficient elimination of L. monocytogenes was observed in spleens of mice fed a diet containing OO at 96 h of infection, despite reductions in IL-12p70 and TNF-␣ production, suggesting an improvement of immune resistance. Overall, our results indicate that the initial reduction of both IL-12 and IFN-␥ production before L. monocytogenes infection represents the most relevant event that corroborates the impairment of immune resistance by n-3 polyunsaturated fatty acids during the different stages of infection. However, we speculate that the modulation of other cytokines must be also involved in this response, because the alteration of cytokine production in mice fed an FO diet in a late phase of L. monocytogenes infection was similar to that in mice fed OO, whereas the ability to eliminate this bacterium from the spleen was improved in the latter group.

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“…The severity of the acute pneumonia was also reduced. Moreover, survival among the mice fed fish oil for 6 weeks was better than among those fed a diet supplemented with corn oil [60]. Saini et al tested sea-cod oil contain- LA and ALA are converted to long chain PUFA sharing the same enzymatic pathway but this conversion is not complete and also variable with individuals.…”

Section: Animal Modelsmentioning

confidence: 99%

Omega-3 long-chain polyunsaturated fatty acids and their bioactive lipids: A strategy to improve resistance to respiratory tract infectious diseases in the elderly?

Korpak,

Rossi,

Van Meerhaeghe

et al. 2024

Nutrition and Healthy Aging

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Age-related changes in organ function, immune dysregulation, and the effects of senescence explain in large part the high prevalence of infections, including respiratory tract infections in older persons. Poor nutritional status in many older persons increases susceptibility to infection and worsens prognosis. Interestingly, there is an association between the amount of saturated fats in the diet and the rate of community-acquired pneumonia. Polyunsaturated fatty acids, particularly omega-3 long chain polyunsaturated fatty acids (ω-3 LC-PUFAs) including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have well-known anti-inflammatory, immunomodulatory, and antimicrobial effects, which may, in theory, be largely induced by PUFAs-derived lipids such as specialized pro-resolving mediators (SPMs). In adults, preliminary results of studies show that ω-3 LC-PUFAs supplementation can lead to SPM generation. SPMs have a crucial role in the resolution of inflammation, a factor relevant to survival from infection independent of the pathogen’s virulence. Moreover, the immune system of older adults appears to be more sensitive to ω-3 PUFAs. This review explores the effects of ω-3 LC-PUFAs, and PUFA bioactive lipid-derived SPMs in respiratory tract infections and the possible relevance of these data to infectious disease outcomes in the older population. The hypothesis that PUFAs have beneficial effects via SPM generation will need to be confirmed by animal experiments and patient-derived data.

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The effect of dietary fish oil on survival after infection with Klebsiella pneumoniae or Streptococcus pneumoniae

Cited by 8 publications

References 15 publications

Long-term flaxseed oil supplementation diet protects BALB/c mice against Streptococcus pneumoniae infection

Long-term flaxseed oil supplementation diet protects BALB/c mice against Streptococcus pneumoniae infection

Assessment of Interleukin-12, Gamma Interferon, and Tumor Necrosis Factor Alpha Secretion in Sera from Mice Fed with Dietary Lipids during Different Stages ofListeria monocytogenesInfection

Omega-3 long-chain polyunsaturated fatty acids and their bioactive lipids: A strategy to improve resistance to respiratory tract infectious diseases in the elderly?

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