The effect of dietary inclusions of guanidinoacetic acid on D1-42 broiler performance and processing yields

Boney, J.W.; Patterson, Paul H.; Solis, Fausto

doi:10.1016/j.japr.2019.10.008

Cited by 8 publications

(11 citation statements)

References 18 publications

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“…Most likely, amino acid levels played a more prominent role than creatine in these diets because blood meal has even lower creatine content than meat and bone meal. Boney et al (2019) observed that the inclusion of GAA in non-animal-protein diets did not affect breast meat yield; however, breast meat yield was reduced by 1.78 percentage points when broilers were provided the diet containing PBP meal devoid of GAA. Therefore, the variable effects in these experiments could be more related to specific nutrient digestibility than to feed ingredients or origin of the protein per se .…”

Section: The Potential Of Gaa To Reduce Myopathies In Poultrymentioning

confidence: 93%

“…Most likely, amino acid levels played a more prominent role than creatine in these diets because blood meal has even lower creatine content than meat and bone meal. Boney et al (2019) observed that the FIGURE 5 | Effect of guanidinoacetic acid (GAA) and organic trace minerals (manganese, Mn, and copper, Cu) on the probability distribution for each wooden breast severity score in Ross-308 broilers at 42 day of age (adapted from Vargas, 2019).…”

Section: The Potential Of Gaa To Reduce Myopathies In Poultrymentioning

confidence: 99%

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The Potential of Guanidino Acetic Acid to Reduce the Occurrence and Severity of Broiler Muscle Myopathies

Oviedo-Rondón

Córdova-Noboa

2020

Front. Physiol.

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Guanidinoacetic acid (GAA) is the biochemical precursor of creatine, which, in its phosphorylated form, is an essential high-energy carrier in the muscle. Although creatine has limited stability in feed processing, GAA is well established as a source of creatine in the animal feed industry. Published data demonstrate beneficial effects of GAA supplementation on muscle creatine, energy compounds, and antioxidant status, leading to improvements in broiler body weight gain, feed conversion ratio, and breast meat yield. Although increases in weight gain and meat yield are often associated with wooden breast (WB) and other myopathies, recent reports have suggested the potential of GAA supplementation to reduce the occurrence and severity of WB while improving breast meat yield. This disorder increases the hardness of the Pectoralis major muscle and has emerged as a current challenge to the broiler industry worldwide by impacting meat quality. Genetic selection, fast-growth rates, and environmental stressors have been identified to be the main factors related to this myopathy, but the actual cause of this disorder is still unknown. Creatine supplementation has been used as a nutritional prescription in the treatment of several muscular myopathies in humans and other animals. Because GAA is a common feed additive in poultry production, the potential of GAA supplementation to reduce broiler myopathies has been investigated in experimental and commercial scenarios. In addition, a few studies have evaluated the potential of creatine in plasma and blood enzymes related to creatine to be used as potential markers for WB. The evidence indicates that GAA could potentially minimize the incidence of WB. More data are warranted to understand the factors affecting the potential efficacy of GAA to reduce the occurrence and severity of myopathies.

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Section: The Potential Of Gaa To Reduce Myopathies In Poultrymentioning

confidence: 93%

“…Most likely, amino acid levels played a more prominent role than creatine in these diets because blood meal has even lower creatine content than meat and bone meal. Boney et al (2019) observed that the FIGURE 5 | Effect of guanidinoacetic acid (GAA) and organic trace minerals (manganese, Mn, and copper, Cu) on the probability distribution for each wooden breast severity score in Ross-308 broilers at 42 day of age (adapted from Vargas, 2019).…”

Section: The Potential Of Gaa To Reduce Myopathies In Poultrymentioning

confidence: 99%

The Potential of Guanidino Acetic Acid to Reduce the Occurrence and Severity of Broiler Muscle Myopathies

Oviedo-Rondón

Córdova-Noboa

2020

Front. Physiol.

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“…In contrast, as a main effect, body weight and gain tended to be improved, but FCR was significantly improved in the GAA diet compared to the control diet. Boney et al (2020) showed an improvement in FCR in birds fed on either plant protein or animal protein-based diets that were supplemented with GAA. Moreover, EFSA (2016); He et al (2019) reported an improvement in both daily weight gain and gain per feed when supplemented with 0.06% or 0.12% GAA.…”

Section: Discussionmentioning

confidence: 97%

“…Feed ingredients of animal origin are rich source of creatine and plant-based ingredients do not contain any metabolites of creatine (Khajali et al 2020). Cre in these animal protein sources was found to be affected during rendering, which makes Cre a lost nutrient in poultry nutrition (Boney et al 2020). GAA is a precursor source of creatine (EFSA 2016), showed better stability during feed processing and storage compared to Cre ( Van der Poel et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Effects of guanidinoacetic acid supplementation on zootechnical performance and some biometric indices in broilers challenged with T₃-Hormone

Khalil

Al-Sagan

Abdellatif

et al. 2021

Italian Journal of Animal Science

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The objective was to elucidate the effects of dietary guanidinoacetic acid (GAA) supplementation on broiler performance, serum enzymes, oxidative biomarkers, mitochondrial activities, carcase traits, gross lesion of cardiac muscle and liver histopathology in broilers challenged with T 3 -hormone. A total-of-192 one-day-old mixed sexed broilers were randomly assigned in a two factorial design, including two dietary treatments; control diet supplemented with or without T 3 -hormone (1.5 ppm) and GAA diet (0.06%) supplemented with or without T 3 -hormone (1.5 ppm). Each group was subdivided into eight replicates. Results showed interactions between GAAxT 3 -hormone. GAA diet significantly mitigated the negative effect of T 3 -hormone on serum total creatine kinase (CK), cardiac muscle (CK-MB), liver malondialdehyde (MDA) and superoxide dismutase (SOD), mitochondrial activities of cardiac muscle and liver histopathological lesion. In conclusion, GAA at a rate of 0.06% may have the potential to mitigate the negative effect of dietary T 3 -hormone but could not reduce the ascites mortality at such inclusion rate. HIGHLIGHTSGAA protected heart muscle. GAA mitigated the oxidative radicals in T 3 -hormone challenged birds. GAA modulated the mitochondrial activities in T 3 -hormone challenged birds.

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“…In practice, it is possible to increase Cre by increasing the arginine: lysine (Arg:Lys) ratio, but only up to a certain limit, otherwise performance may be compromised due to Arg-Lys antagonism [ 16 ]. Feeds of animal origin have a significant but highly variable Cre content which is negatively affected by the rendering process [ 13 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Guanidinoacetic Acid Supplementation on Productive Performance, Pectoral Myopathies, and Meat Quality of Broiler Chickens

Khalil

Saenbungkhor²,

Kesnava

et al. 2021

Animals

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The effects of guanidinoacteic acid (GAA) supplementation on productive performance, pectoral myopathies, and meat quality of broilers were studied. Treatments consisted of corn/soybean-based diets with a GAA supplement (0%, 0.06%, and 0.12%). A total of 546 one-day-old Ross-308 males were randomly allocated to 42 floor pens with 14 replicates (13 birds/pens) for each treatment. The results showed that GAA at doses of 0.06% and 0.12% improved feed conversion, increased the percentage of normal breast, and decreased the severity of wooden breast. Breast muscle myopathy severity was positively correlated with heavy birds and negatively correlated with breast muscle creatine and glycogen. Breast muscle creatine and glycogen correlated positively with normal, less severe pectoral myopathies and meat quality. In conclusion, GAA supplementation improved broiler performance without exacerbating pectoral myopathy or affecting meat quality.

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The effect of dietary inclusions of guanidinoacetic acid on D1-42 broiler performance and processing yields

Cited by 8 publications

References 18 publications

The Potential of Guanidino Acetic Acid to Reduce the Occurrence and Severity of Broiler Muscle Myopathies

The Potential of Guanidino Acetic Acid to Reduce the Occurrence and Severity of Broiler Muscle Myopathies

Effects of guanidinoacetic acid supplementation on zootechnical performance and some biometric indices in broilers challenged with T₃-Hormone

Effects of Guanidinoacetic Acid Supplementation on Productive Performance, Pectoral Myopathies, and Meat Quality of Broiler Chickens

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The effect of dietary inclusions of guanidinoacetic acid on D1-42 broiler performance and processing yields

Cited by 8 publications

References 18 publications

The Potential of Guanidino Acetic Acid to Reduce the Occurrence and Severity of Broiler Muscle Myopathies

The Potential of Guanidino Acetic Acid to Reduce the Occurrence and Severity of Broiler Muscle Myopathies

Effects of guanidinoacetic acid supplementation on zootechnical performance and some biometric indices in broilers challenged with T3-Hormone

Effects of Guanidinoacetic Acid Supplementation on Productive Performance, Pectoral Myopathies, and Meat Quality of Broiler Chickens

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Effects of guanidinoacetic acid supplementation on zootechnical performance and some biometric indices in broilers challenged with T₃-Hormone