The Effect of Dietary Protein Depletion and Repletion on Rat Hepatic Mixed Function Oxidase Activities

Epidemiology and Mechanisms Relating Diet to Risk of Colorectal Cancer

“…There is an extensive literature showing that most P450 enzyme system activity is decreased when protein intake is reduced, probably because protein synthesis and liver cell proliferation are retarded (see Yang & Yoo, 1991). Hayes et al (1978) found that changes occurred within 1-2 weeks of a change in protein intake in rats. Phase I1 enzyme activity may also be reduced, so that the net result may be an increase or decrease in toxicity of xenobiotics in protein deficient animals (Yang & Yoo, 1991).…”

Nutrition and Cancer: An Historical Perspective.—The Past, Present, and Future of Nutrition and Cancer. Part 2. Misunderstanding and Ignoring Nutrition

“…First, epidemiological associations of nutritional experience with cancer are far more convincing than associations of carcinogen exposure with cancer (17) and, second, all initiating carcinogens are dependent on activation by the cytochrome p450 system which itself is profoundly influenced by nutrition (15), especially by dietary-animal-based protein (29)(30)(31)(32)(33)(34). These findings have broad implications and seriously question the utility of the chemical carcinogen animal bioassay program.…”

Liver Microsomal Mixed-Function Oxidases in Response to Dietary Whole Egg Protein Levels in Rats.

“…SAITO et al normal levels (2,4,(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). By contrast, dietary protein excess is reported to increase (11) or decrease (13) the activity of liver microsomal MFO system.…”