The effect of diets containing different monoand disaccharides on the incidence of dental caries in the albino rat

Green, R.M.; Hartles, R.L.

doi:10.1016/0003-9969(69)90225-8

Cited by 37 publications

(14 citation statements)

References 14 publications

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“…Rat feeding experiments have shown similar results [e.g., Green and Hartles, 1969], although when the ani mals plaques are dominated by mutans streptococci great er caries development is seen on smooth surfaces (but not fissures) with sucrose than with glucose [Tanzer, 1979].…”

Section: Individual Mono-and Disaccharides and Cariogenic Potentialmentioning

confidence: 51%

Extrinsic and Intrinsic Sugars: A Review of Recent UK Recommendations on Diet and Caries

Edgar

1993

Caries Res

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Development of caries in man is associated with dietary sugars, but the relationship between sugar contents of individual foods and their cariogenic potential is unclear. A recent report categorized dietary sugars as intrinsic (mainly fruit and vegetable) and extrinsic (mainly added sugars, milk, and fruit juices) and concluded that consumption of extrinsic sugars (except milk) should be replaced with that of intrinsic sugars. This paper examines briefly the dental consequences of the recommendations.

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Section: Individual Mono-and Disaccharides and Cariogenic Potentialmentioning

confidence: 51%

Extrinsic and Intrinsic Sugars: A Review of Recent UK Recommendations on Diet and Caries

Edgar

1993

Caries Res

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“…The cariogenic potential of the sugary constituents of honey is a subject of debate, and evidence based on previous reports is inconclusive. In animal models, comparable cariogenic activity was reported for glucose and fructose, the main sugars of honey, compared to sucrose (14,15). In a recent study, rats were fed different fluids to test their cariogenicity (9).…”

Section: Fig 4 S Mutans Viability Presented As Numbers Of Cfu In a Lmentioning

confidence: 88%

Effect of Honey on Streptococcus mutans Growth and Biofilm Formation

Nassar

Gregory

2012

Appl Environ Microbiol

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Because of the tradition of using honey as an antimicrobial medicament, we investigated the effect of natural honey (NH) on Streptococcus mutans growth, viability, and biofilm formation compared to that of an artificial honey (AH). AH contained the sugars at the concentrations reported for NH. NH and AH concentrations were obtained by serial dilution with tryptic soy broth (TSB). Several concentrations of NH and AH were tested for inhibition of bacterial growth, viability, and biofilm formation after inoculation with S. mutans UA159 in 96-well microtiter plates to obtain absorbance and CFU values. Overall, NH supported significantly less (P < 0.05) bacterial growth than AH at 25 and 12.5% concentrations. At 50 and 25% concentrations, both honey groups provided significantly less bacterial growth and biofilm formation than the TSB control. For bacterial viability, the results for all honey concentrations except 50% NH were not significantly different from those for the TSB control. NH was able to decrease the maximum velocity of S. mutans growth compared to AH. In summary, NH demonstrated more inhibition of bacterial growth, viability, and biofilm formation than AH. This study highlights the potential antibacterial properties of NH and could suggest that the antimicrobial mechanism of NH is not solely due to its high sugar content.H oney has been used as a source of nutrients as well as a medicine since ancient times (3). Recent publications indicating the effect of honey in the management of certain conditions have rekindled interest in honey as a natural therapeutic agent. For example, honey can be used as a temporary dressing in burns (20). It has also been found to be effective in the management of radiation-induced mucositis in patients receiving head and neck radiotherapy (26). In addition, Robson and colleagues recorded accelerated healing when honey was used as a wound dressing material in a randomized clinical trial (28).The antibacterial properties of honey have been well documented (37). However, the specific antimicrobial mechanism of honey is still unclear (7). Among the possible mechanisms are the presence of inhibitory factors such as flavonoids (16) and hydrogen peroxide (35, 36), low pH (38), and high osmolarity due to its sugar concentration (38).Honey may have a similar antibacterial effect on Streptococcus mutans, which is considered the main causative organism of dental caries (21). S. mutans along with other oral bacteria forms on the tooth surface a microbial community surrounded by extracellular matrix and salivary proteins (22), collectively known as dental biofilm. Cariogenic bacteria within this biofilm utilize dietary sugars and produce lactic acid as a by-product (34). This acid attacks and demineralizes the tooth structure, leading to decay.Very limited studies have investigated the effect of honey on S. mutans. These studies investigated the effect of honey on several strains of oral bacteria (7). Here, we tried to explore the effect of honey on the growth and viability of S. mutans...

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“…Diet SSP 20/5 pressed to pellets virtually failed to induce advanced car ious lesions and S. mutans did not esta blish in the oral cavity (table VI). Green and Hartles [ 1969], Grenby and Hutchinson [1969] and Shaw et al [1967] also reported a high potential cariogenicity of glucose, although mostly lower than sucrose. In hamsters it was found that caries inducing streptococci established less effectively on a high glucose diet than on a high sucrose diet [Krasse, 1965a, b;Edwardsson and Krasse, 1967].…”

Section: Discussionmentioning

confidence: 99%

A Purified Cariogenic Diet for Rats to Test Sugar Substitutes with Special Emphasis on General Health

Havenaar¹,

Veld²,

Stoppelaar³

et al. 1983

Caries Res

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As a consequence of the partial substitution of sucrose by sugar alcohols in the cariogenic diets 580 or 2000, rats often suffer severe diarrhoea, resulting in retarded body weight gains, impaired general health and sometimes high mortality. The purpose of the present study was to develop a more suitable diet to test sugar substitutes, with special emphasis on the general health of the rats and less extreme caries scores in comparison to diet 2000. A purified powder diet (SSP), which meets the nutritional requirements of the rat and containing 50% carbohydrates in which the ratios of starch, sugars and sugar substitutes can be varied, was tested. The results showed that: (1) Streptococcus mutans established well in the oral cavity of the rats; (2) this diet induced reproducible and moderate numbers of carious fissure lesions in S. mutans inoculated rats while non-inoculated animals remain almost caries free; (3) polyols can be added to this diet within reasonable limits without inducing diarrhoea and without influencing body weight gains and general health. In addition it was shown that the partial substitution of starch by xylitol resulted in a statistically significant caries reduction (p < 0.02), both in S. mutans serotype c and serotype d inoculated rats.

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The effect of diets containing different monoand disaccharides on the incidence of dental caries in the albino rat

Cited by 37 publications

References 14 publications

Extrinsic and Intrinsic Sugars: A Review of Recent UK Recommendations on Diet and Caries

Extrinsic and Intrinsic Sugars: A Review of Recent UK Recommendations on Diet and Caries

Effect of Honey on Streptococcus mutans Growth and Biofilm Formation

A Purified Cariogenic Diet for Rats to Test Sugar Substitutes with Special Emphasis on General Health

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