The low-frequency vibration and radiation performance of a locally resonant (LR) plate with periodic multiple resonators is studied in this paper, with both infinite and finite structure properties examined. For the finite cases, taking the LR plate attached with two periodic arrays of resonators as an example, the forced vibration response and the radiation efficiency are theoretically derived by adopting a general model with elastic boundary conditions. Through a comparison with the band structures calculated by the plane-wave-expansion method, it shows that the band gaps in the infinite LR plate are in good agreement with the vibration-attenuation bands in the finite LR plate, no matter what boundary conditions are applied to the latter. In contrast to the vibration reduction in the band gaps, the radiation efficiency of the finite LR plate is sharply increased in the band-gap frequency ranges. Furthermore, the acoustic power radiated from the finite LR plate can be seriously affected by its boundary conditions. For the LR plate with greater constraints, the acoustic power is reduced in the band-gap frequency ranges, while that from the one with fully free boundary conditions is increased. When further considering the damping loss factors of the resonators, the attenuation performance can be improved for both the vibration and radiation of the LR plate.