The Effect of Different Diet on Saliva

Tomečková, Vladimı́ra; Krajčíková, Kristína; Dolinská, S.; Komanický, Vladimír; Samuely, Tomáš

doi:10.4236/sar.2017.54004

Cited by 5 publications

(6 citation statements)

References 22 publications

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“…To the best of our knowledge, this is the rst paper to study the histological effect of a keto diet on the structure of salivary glands. Therefore, our result is nearly in agreement with Tomečková et al (2017) [25], who studied the effect of KD on human saliva compared to a low-carb diet and mixed them by atomic force microscopy. They found that the crystals in the KD group had a larger size, from 1000 nm to 2000 nm, and the highest surface roughness reached 84.9 nm, in comparison to the mixed diet, which showed crystal sizes from 400 nm to 1000 nm with an increased surface roughness of 25.2 nm.…”

Section: Discussionsupporting

confidence: 92%

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Comparative Effect of Ketogenic and Chitosan-Based Diets on Submandibular Salivary Gland Morphology in Rats: A Histological and Immuno-Histochemical Analysis

Aboulfotoh

2023

Preprint

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Objective: This study was carried out in the submandibular salivary glands (SSGs) of rats to demonstrate the effect of a ketogenic diet (KD) in comparison with dietary chitosan supplementation. Method: Eighteen albino rats were randomly divided into three equal groups. Rats in Group I were fed a balanced diet and considered controls. Meanwhile, those of Groups II and III were fed a KD, a balanced diet with high molecular weight chitosan, respectively. After 45 days, rats were euthanized, and the SSGs were dissected carefully for staining with hematoxylin and eosin (H&E), alpha-smooth muscle actin (α-SMA) immunohistochemical staining, and Congo red special stain. Quantitative data from α-SMA staining and Congo red staining were statistically analyzed using one-way ANOVA followed by Tukey's multiple comparisons post hoc test. Results: Regarding Congo red and α-SMA staining, one-way ANOVA revealed a significant difference between the three groups. For α-SMA staining and Congo red staining, Group II had the highest mean values of 91.41 ± 3.30 and 68.10 ± 5.04, respectively, while Group I had the lowest values of 56.13 ± 3.96 and 16.87 ± 2.19, respectively. Group III had mean values of 60.70 ± 3.55 for α-SMA and 19.50 ± 1.78 for Congo red. Tukey's multiple comparisons post hoc test revealed significant differences between groups I & II and between groups II & III (P ˂ 0.05). Meanwhile, there was a nonsignificant difference between groups I and III (P ˃ 0.05). Conclusion: A KD has a deleterious effect on rats' SSG, and dietary chitosan supplementation ameliorates these damaging effects.

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Section: Discussionsupporting

confidence: 92%

“…Currently, the KD changes from epileptic therapy to a traditional diet used for weight loss. However, it may have some side effects on long-term use [25]. In the present study, the aim was to test the null hypothesis that there is no difference between the three groups against the alternative group.…”

Section: Discussionmentioning

confidence: 95%

Comparative Effect of Ketogenic and Chitosan-Based Diets on Submandibular Salivary Gland Morphology in Rats: A Histological and Immuno-Histochemical Analysis

Aboulfotoh

2023

Preprint

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“…Currently, the KD changes from epileptic therapy to a traditional diet used for weight loss. However, it may have some side effects on long-term use [ 26 ]. In the present study, the main objective was to test the null hypothesis that there is no difference between the three groups against the alternative group.…”

Section: Discussionmentioning

confidence: 99%

The effects of ketogenic and chitosan-based diets on submandibular salivary gland in rat model: a comparative histological study

Aboulfotoh

2024

BMC Oral Health

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Objective This study was carried out in the submandibular salivary glands (SSGs) of rats to demonstrate the effect of a ketogenic diet (KD) in comparison with dietary chitosan supplementation. Method Eighteen albino rats were randomly divided into three equal groups of six animals each. Rats in Group I were fed a balanced diet and considered controls. Meanwhile, those of Groups II and III were fed a KD, a balanced diet with high molecular weight chitosan, respectively. After 45 days, rats were euthanized, and the SSGs were dissected carefully for staining with hematoxylin and eosin (H&E), alpha-smooth muscle actin (α-SMA) immunohistochemical staining, and Congo red special stain. Quantitative data from α-SMA staining and Congo red staining were statistically analyzed using one-way ANOVA followed by Tukey’s multiple comparisons post hoc test. Results Regarding Congo red and α-SMA staining, one-way ANOVA revealed a significant difference between the three groups. For α-SMA staining and Congo red staining, Group II had the highest mean values of 91.41 ± 3.30 and 68.10 ± 5.04, respectively, while Group I had the lowest values of 56.13 ± 3.96 and 16.87 ± 2.19, respectively. Group III had mean values of 60.70 ± 3.55 for α-SMA and 19.50 ± 1.78 for Congo red. Tukey’s multiple comparisons post hoc test revealed significant differences between groups I & II and between groups II & III (P < 0.05). Meanwhile, there was a nonsignificant difference between groups I and III (P > 0.05). Conclusion A KD has a deleterious effect on rats’ SSG whatever the test we used, and dietary chitosan supplementation ameliorates these damaging effects.

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“…This situation is further exacerbated by alimentary habits or lifestyles such as consuming sweet food and drinks. 18,19,20 Xerostomia were the most common oral manifestations found due to the usage effects of combination inhalation drug corticosteroid and β2-agonist. Therefore, methods to prevent and minimalize oral manifestation were needed.…”

Section: Discussionmentioning

confidence: 99%

<strong>Differences in the salivary flow rate, buffer capacity, and pH, based on the length of inhalants usage in bronchial asthma patients</strong>

2022

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Introduction: Asthma or bronchial asthma is a chronic respiratory tract inflammation process involving many cells, including their elements, and can cause severe and plentiful responses from the respiratory tract. Administration of inhalation drugs is the primary medication in treating bronchial asthma. Inhalants are given appropriately with dosage and usage period based on the severity level of bronchial asthma. This research aimed to analyse the differences in the salivary flow rate, buffer, and pH, based on the length of inhalants usage in bronchial asthma patients. Methods: The research was descriptive-comparative involving 40 bronchial asthma patients (6 male and 34 female) from the Community Lung Health Center of Bandung, taken as samples using the central theorem limit sampling method. The subjects were ordered to collect their saliva in the saliva collection cups with a draining method. Then, the salivary flow rate, buffer, and pH were examined. Data distribution was tested, resulting in normally distributed data; thus, a parametric independent t-test with a significant level of 0.05 was applied. Results: Subjects in the group of inhalant usage for more than ten years had low and very low categories of salivary flow rate, buffer, and pH. There were significant differences in the salivary flow rate, buffer, and pH of the bronchial asthma patients based on their length of inhalants usage (1-5 years; >5 years–10 years; >10 years; p<0.05). Conclusions: There are differences in the salivary flow rate, buffer, and pH based on the length of inhalants usage in bronchial asthma patients. The longer the usage period, the lower the salivary flow rate, buffer, and pH.

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The Effect of Different Diet on Saliva

Cited by 5 publications

References 22 publications

Comparative Effect of Ketogenic and Chitosan-Based Diets on Submandibular Salivary Gland Morphology in Rats: A Histological and Immuno-Histochemical Analysis

Comparative Effect of Ketogenic and Chitosan-Based Diets on Submandibular Salivary Gland Morphology in Rats: A Histological and Immuno-Histochemical Analysis

The effects of ketogenic and chitosan-based diets on submandibular salivary gland in rat model: a comparative histological study

<strong>Differences in the salivary flow rate, buffer capacity, and pH, based on the length of inhalants usage in bronchial asthma patients</strong>

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