The effect of different dose levels of degradable starch microspheres (Spherex®) on the distribution of a cytotoxic drug after regional administration to tumour-bearing rats

Teder, H.; Johansson, Charlotta; d'Argy, R.; Lundin, N.; Gunnarsson, Per Olov

doi:10.1016/0959-8049(95)00352-j

Cited by 15 publications

(7 citation statements)

References 7 publications

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“…The use of microspheres as a dosage form for the administration of active substances is attracting growing interest, especially as a means of delivering proteins (Harris, Gauden, Fraser, Williams, & Parker, 2002;Huang, Mehta, & DeLuca, 1997;Morise et al, 2006;Teder, Johansson, d'Argy, Lundin, & Gunnarsson, 1995). Starch is one of the polymers that is suitable for the production of microspheres.…”

Section: Introductionmentioning

confidence: 99%

Changes in starch structure during manufacturing of starch microspheres for use in parenteral drug formulations: Effects of temperature treatment

Elfstrand

Eliasson

Wahlgren

2009

Carbohydrate Polymers

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Section: Introductionmentioning

confidence: 99%

Changes in starch structure during manufacturing of starch microspheres for use in parenteral drug formulations: Effects of temperature treatment

Elfstrand

Eliasson

Wahlgren

2009

Carbohydrate Polymers

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“…Microspheres could be administered through the classical parenteral ways (e.g., intramuscular or subcutaneous injections) or alternatively through an embolization procedure to selectively target specific organs as in antitumoral therapies. In addition, the PMs could find an interesting therapeutic application for the delivery of nucleic acid based drugs to the skin and through mucosal tissues (nasal, oral, and vaginal) (Lindberg, Lote, and Teder 1984;Teder and Johanssan 1993;Illum et al 1984;Hamdi, Ponchel, and Duchene 1998).…”

Section: Rational Of Polysaccharide Microspherementioning

confidence: 98%

Aminated Polysaccharide Microspheres as DNA Delivery Systems

et al. 2003

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This article describes the production and characterization of cationic microparticles based on pullulan and starch for the delivery of nucleic acids. The microparticles were prepared by chemically cross-linkinking of a polymer solution dispersed in organic phase, followed by amination with N, N-diethyl-2-chloroethyl amine hydrochloride, or N-glycidyl-N,N-dimethyl-N-methylammonium chloride. The association of desoxyribonucleotide (DNA) with positively charged microparticles was determined. The association capacity and the affinity of microspheres for DNA were investigated as a function of type of polysaccharide, content and basicity of the amino groups. It was found that the both types of carriers synthetized display a high affinity for defibrotide due to the high porosity of polysaccharide microspheres (PMs). The in vitro release kinetics from microspheres showed an initial fast release of DNA (30 min) followed by slower release rate over 14 days. DNA release was influenced by the ionic strength of the receiving fluid. In addition, DNA release was slightly more rapid from pullulan than from starch complexes. DNA stability studies were performed by agarose gel, indicating no degradation even after 14 days. All the produced cationic microspheres were able to quantitatively load DNA. The release of DNA from PMs was strongly affected by the ionic strength of the receiving fluid. Finally, agarose gel electrophoresis of DNA released from microspheres indicated that no DNA degradation occurs even after 14 days of release from PMs.

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“…Microspheres, used for delivery of anticancer agents, can be targeted by the blood ow to any organ supplied by a developed vascular bed, including tumor microvasculature. Tumor to normal tissue ratios of up to 10:1 have been achieved using microspherical delivery of chemotherapeutic drugs (Teder & Johansson 1993;Zavgorodni 1996).…”

Section: Limitations Of Current Gene Transfer Technologiesmentioning

confidence: 99%

A Microsphere-Lipoplex (Microplex) Vector for Targeted Gene Therapy of Cancer. I. Construction and In Vitro Evaluation

et al. 1999

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The effect of different dose levels of degradable starch microspheres (Spherex®) on the distribution of a cytotoxic drug after regional administration to tumour-bearing rats

Cited by 15 publications

References 7 publications

Changes in starch structure during manufacturing of starch microspheres for use in parenteral drug formulations: Effects of temperature treatment

Changes in starch structure during manufacturing of starch microspheres for use in parenteral drug formulations: Effects of temperature treatment

Aminated Polysaccharide Microspheres as DNA Delivery Systems

A Microsphere-Lipoplex (Microplex) Vector for Targeted Gene Therapy of Cancer. I. Construction and In Vitro Evaluation

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