The effect of different types of exercise training on diet-induced obesity in rats, cross-talk between cell cycle proteins and apoptosis in testis

Azar, Javad Tolouei; Maleki, Aref Habibi; Moshari, Sana; Razi, Mazdak

doi:10.1016/j.gene.2020.144850

Cited by 12 publications

(5 citation statements)

References 29 publications

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“…Studies have found that the sperm DFI is positively correlated with obesity, and obesity-related abnormal lipid metabolism and reproductive function-altered hormones may lead to decreased sperm quality ( 21 ). This study found that the sperm DFI was negatively correlated with male BMI, which was inconsistent with the results of studies by Fariello ( 22 ), Tolouei ( 23 ), Ferigolo ( 24 ) and others showing that obesity led to an increased the sperm DFI. There was no significant correlation between sperm DFI and infertility years, suggesting that infertility years can be influenced by many factors.…”

Section: Discussioncontrasting

confidence: 99%

Influence of sperm DNA fragmentation on the clinical outcome of in vitro fertilization-embryo transfer (IVF-ET)

et al. 2022

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PurposeTo evaluate the effect of elevated sperm DNA fragmentation index (DFI) on fresh and frozen embryo transfer cycles.MethodsA retrospective study was performed with 549 fresh embryo transfer cycles and 1340 frozen embryo transfer cycles after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) from 2016 to 2021.ResultsThe statistical results of 549 fresh embryo transfer cycles showed that the delivery rate in the normal sperm DFI group (43.9% vs. 27.1%, P = 0.014) was significantly higher than that in the abnormal sperm DFI group, and there were no significant differences in the biochemical pregnancy rate (59.0% vs. 50.8%, P = 0.232), clinical pregnancy rate (53.1% vs. 40.7%, P = 0.072), or miscarriage rate (17.3% vs. 33.3%, P = 0.098) between the two groups. The results of 1340 frozen embryo transfer cycles showed that the biochemical pregnancy rate (57.9% vs. 45.6%, P = 0.006) and clinical pregnancy rate (50.3% vs. 40.7%, P = 0.027) in the normal sperm DFI group were significantly higher than those in the abnormal sperm DFI group. The delivery rate (40.9% vs. 33.3%, P = 0.074) and miscarriage rate (18.6% vs. 18.0%, P = 0.919) were not significantly different between the two groups.ConclusionThe increase of sperm DFI significantly reduced the delivery rate of fresh embryo transfer cycles and the biochemical pregnancy rate and clinical pregnancy rate of frozen embryo transfer cycles.

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Section: Discussioncontrasting

confidence: 99%

Influence of sperm DNA fragmentation on the clinical outcome of in vitro fertilization-embryo transfer (IVF-ET)

et al. 2022

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“…In addition, the infiltration of a high-fat environment could also induce Leydig cell apoptosis via the accumulation of oxidation products and the release of ceramide [ 34 ], which further aggravates the reduction in testosterone production induced by obesity. However, moderate-intensity exercise training could promote lipolysis and also reduce triglyceride and apoptotic cell numbers caused by high-fat diet [ 35 ]. All these findings showed that exercise intervention could correct the adverse effects of a high-fat diet on the hypothalamus and testes of male rats.…”

Section: Discussionmentioning

confidence: 99%

Effects of high-fat diet and treadmill running on the hypothalamic Kiss-1–GPR54 signaling pathway in male growing rats

Feng

Liang

et al. 2022

Hormones

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Background Kiss-1 neuron, one of the metabolic sensors in the hypothalamus, is necessary for puberty initiation. It acts through G protein-coupled receptor, known as GPR54. In this study, the mechanism of the hypothalamic Kiss-1–GPR54 signaling pathway in a high-fat diet and exercise was investigated in growing male rats. Methods A total of 135 3-week-old male weaned rats were kept on a high-fat diet (HFD) and exercise (60–70% $$\dot{\mathrm V}{\mathrm O}_{2\max}$$ V ˙ O 2 max , 1 h/day, 5 days/week). They were randomly divided, as follows: control group (C); normal diet + exercise group (CE); HFD group (H); and HFD + exercise group (HE). Hypothalamus, testis, and serum samples of each group were collected on postnatal day (PND) 21 (early childhood), 43 (puberty), and 56 (maturity). Immunofluorescence, quantitative real-time PCR, hematoxylin and eosin staining, and chemiluminescent immunoassays were used in the study. ANOVA was used to analyze the effects of age (PNDs 21, 43, and 56), exercise (exercise and sedentariness), and diet (high-fat and normal) on the biological indices of rats. Results mRNA and protein expression of Kiss-1 and GPR54 in the hypothalamus gradually increased along with growth and peaked at PND 43, while those in serum testosterone increased and peaked at PND 56. The high-fat diet increased the expression of the Kiss-1–GPR54 system in the hypothalamus, whereas the serum testosterone decreased during different stages of growth. Exercise decreased the expression of Kiss-1 at PND 56 and increased it at PND 43. Meanwhile, it decreased testosterone and the deposition of lipid droplets in the testis at all ages of development. Conclusions The expression of Kiss-1–GPR54 in male rats showed fluctuating changes during growth and development. The high-fat diet was able to upregulate the expression of the Kiss-1–GPR54 system in the hypothalamus. The exercise was able to correct the adverse effect of the high-fat diet on the Kiss-1–GPR54 signaling pathway in the hypothalamus and the function of the hypothalamic-pituitary–gonadal (HPG) axis, but had age-specific effects on the male rats’ development.

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“…For instance, Huang et al (2016) reported that IL‐6 regulates the gene expression of spermatogonial stem cell's self‐renewal genes, such as Sox‐2. Considering IL‐6 increment in excessive exercise condition (Maleki et al, 2017, 2019), it may explain the exercise‐induced germ cell arrest in exercise condition (Samadian, Tofighi, et al, 2019; Tolouei Azar et al, 2020).…”

Section: Effect Of Sport On Spermatogenesismentioning

confidence: 99%

“…In corroboration with these results, Toloui‐Azar and colleagues revealed an improvement in Cyclin D1, and Cdk‐4 (cyclin‐dependent kinase 4) protein levels, provoking germ cells cell cycle machinery and spermatogenesis following diminished cholesterol level by MICT, HICT and HIIT treadmill running in obese rats (Figure 4). However, moderate‐intensity training significantly reduced apoptotic germ cells number and DNA damage levels in testicular tissue compared to HICT and HIIT rats (Tolouei Azar et al, 2020). Moreover, Xuejie and colleagues demonstrated a significant decrement in MICT trained obese group body mass and pro‐inflammatory cytokines (NF‐kB, IL‐1β and TNF‐α) compared to obese and HICT obese groups.…”

Section: Exercise Positive Impacts On Male Infertilitymentioning

confidence: 99%

Influence of physical activity on male fertility

et al. 2022

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Infertility is a worldwide issue impacting 15% of couples' population. Male‐related infertility results in almost 50% of these cases. Considering lifestyle factors associated with infertility, here in this literature review article, we aimed to discuss training/sport effects on male‐related infertility. Regarding this issue, human and animal model studies related to the subject were gathered and analysed. Exercise is well known as a general improving factor, however, excessive exercise can result in male infertility due to reduced hypothalamus–pituitary–gonadal axis (HPT) function, increased oxidative stress and chronic inflammation. Consequently, these underlying impacts result in a low testosterone production, and reduced semen quality, and can lead to infertility. In contrast, it has been revealed that exercise can improve male fertility status in lifestyle‐induced infertility condition such as obesity and diabetes. Indeed, exercise, by increasing testicular antioxidant defence, reducing pro‐inflammatory cytokines level and enhancing the steroidogenesis process, leads to improved spermatogenesis and semen quality in lifestyle‐induced infertility. In fact, it seems that individual health status as well as exercise volume, intensity and duration are effective‐involved co‐factors that influence the impact that exercise will promote on male fertility. Regarding these findings, it is important to study exercise different impacts in further clinical trials in order to generate preservative guidelines for exercise and also considering exercise as a treatment option in lifestyle‐induced disease management.

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The effect of different types of exercise training on diet-induced obesity in rats, cross-talk between cell cycle proteins and apoptosis in testis

Cited by 12 publications

References 29 publications

Influence of sperm DNA fragmentation on the clinical outcome of in vitro fertilization-embryo transfer (IVF-ET)

Influence of sperm DNA fragmentation on the clinical outcome of in vitro fertilization-embryo transfer (IVF-ET)

Effects of high-fat diet and treadmill running on the hypothalamic Kiss-1–GPR54 signaling pathway in male growing rats

Influence of physical activity on male fertility

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