The effect of dimethyl fumarate on gene expression and the level of cytokines related to different T helper cell subsets in peripheral blood mononuclear cells of patients with psoriasis

Abstract

These data show the effectiveness of DMF in modulating Th17 cells in addition to Th1/Th2 cells and reflect one of the underlying mechanisms of action of DMF in psoriasis. These findings may also support the possible benefits of using fumarate in the treatment of other autoimmune diseases in the pathogeneses of which Th1 and Th17 cells play major roles.

Body surface area and B-cell repopulation

“…By contrast, no early transcriptional changes were identified in nonresponders, who also showed greater expression of proinflammatory pathway genes as compared with healthy controls. Findings from this study confirm previously reported modulating effects of DMF on genes related to antioxidant, 3 anti-inflammatory, 4 and NFκB pathways. 5 The authors acknowledge the small sample size and the use of only 3 time points in sample testing, indicating the need of further confirmatory work.…”

Dimethyl Fumarate Selectively Reduces Memory T Cells and Shifts the Balance between Th1/Th17 and Th2 in Multiple Sclerosis Patients

“…Although earlier in vitro studies suggested that DMF mainly suppresses Th1 responses in psoriasis (45), a more recent study of DMF-treated psoriasis patients has shown that DMF modulates Th17 cells in addition to Th1/Th2 cells (46). DMF seems to exert similar multifaceted effects on T helper cells in MS, as we show in this study.…”

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

“…More recently, DMF has demonstrated its efficacy in the treatment of adults with moderate to severe chronic plaque psoriasis in a phase III trial (BRIDGE) . The mechanism of action underlying fumarates in remission of psoriatic lesions includes the decrease in the number of peripheral T cells along with a shift from a Th1 toward a Th2 immune response (Ghoreschi et al, 2011;Tahvili et al, 2015). In another autoimmune disease, SLE, fumaric acid esters have been used as systemic combination therapy in the treatment of severe, extensive, and refractory cutaneous manifestations (Saracino and Orteu, 2017).…”