The effect of diminazene aceturate and isometamidium chloride on cultured procyclic forms of susceptible and drug-resistant Trypanosoma congolense

Elrayah, Intisar E.; Kaminsky, Ronald

doi:10.1016/0001-706x(91)90039-m

Acta Tropica

1991

DOI: 10.1016/0001-706x(91)90039-m

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The effect of diminazene aceturate and isometamidium chloride on cultured procyclic forms of susceptible and drug-resistant Trypanosoma congolense

Intisar E. Elrayah

Ronald Kaminsky

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Cited by 7 publications

References 14 publications

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In vitro drug sensitivity ofTrypanosoma congolense isolates

Brun

Rab

1991

Parasitol Res

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The sensitivity of Trypanosoma congolense isolates to diminazene and isometamidium was determined using an incorporation assay based on the uptake of [3H]-hypoxanthine in the presence of serial drug dilutions. The bloodstream forms of the different isolates exhibited variation in their sensitivity to the drugs that correlated well with the in vivo drug response. For diminazene, the sensitivity of the most sensitive population was 40 times that of the least sensitive population. For isometamidium, the IC50 values (the drug concentrations that decreased radiolabel incorporation by 50%) lay in a similar range, except for those found for two isolates from lions, which were 10(3)-10(4) times more sensitive than the isolates from cattle. The sensitivity of procyclic forms differed markedly from that of the bloodstream stages. Therefore, it must be concluded that the procyclic stage does not reflect the sensitivity of the bloodstream forms of T. congolense and that the former should not be used for determinations of in vitro drug sensitivity.

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In vitro drug sensitivity ofTrypanosoma congolense isolates

Brun

Rab

1991

Parasitol Res

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In vitro assays to determine drug sensitivities of African trypanosomes: a review

Kaminsky

Brun

1993

Acta Tropica

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An in vitro assay for drug sensitivity of Trypanosoma congolense using in vitro-derived metacyclic trypanosomes

Gray¹,

Peregrine

1993

Acta Tropica

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The effect of diminazene aceturate and isometamidium chloride on cultured procyclic forms of susceptible and drug-resistant Trypanosoma congolense

Cited by 7 publications

References 14 publications

In vitro drug sensitivity ofTrypanosoma congolense isolates

In vitro drug sensitivity ofTrypanosoma congolense isolates

In vitro assays to determine drug sensitivities of African trypanosomes: a review

An in vitro assay for drug sensitivity of Trypanosoma congolense using in vitro-derived metacyclic trypanosomes

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